Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Andrea D. Weston"'
Autor:
Chorom Pak, Kaylene J. Simpson, Andrea D. Weston, Mary Ellen Cvijic, Kenda Evans, Andrew D. Napper
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100146- (2024)
Here we offer perspectives on phenotypic screening based on a wide-ranging discussion entitled “Phenotypic screening, target ID, and multi-omics: enabling more disease relevance in early discovery?” at the Screen Design and Assay Technology Speci
Externí odkaz:
https://doaj.org/article/20c8abe6e30145868863ebbf40d2da1f
Autor:
Kristin L. Rockwell, Paula M. Loria, Yue-Ming Wang, Marie-Claire Peakman, Andrea D. Weston, Claire M. Steppan, Regis Doyonnas, Fabien Vincent
Publikováno v:
Cell Chemical Biology. 27:1332-1346
The promise of phenotypic screening resides in its track record of novel biology and first-in-class therapies. However, challenges stemming from major differences between target-based and phenotypic screening do exist. These challenges prompted us to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b71b25d5a4f6efc33dabb4992b5aad
https://doi.org/10.1016/j.chembiol.2020.08.009
https://doi.org/10.1016/j.chembiol.2020.08.009
Autor:
Andrea D. Weston, Marco Mariotti, Dong Yan, Michael C. Bassik, Robert V. Stanton, Hualin S. Xi, Estel Aparicio-Prat, Jean-Philippe Fortin, Gaelen T. Hess
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, Vol 16, Iss 9, p e0257537 (2021)
PLoS ONE
Universidad de Barcelona
PLoS ONE, Vol 16, Iss 9, p e0257537 (2021)
PLoS ONE
Background: CRISPR base editors are powerful tools for large-scale mutagenesis studies. This kind of approach can elucidate the mechanism of action of compounds, a key process in drug discovery. Here, we explore the utility of base editors in an earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c0ca6f9b0b2575d8c0a2a63639f238
http://hdl.handle.net/2445/184530
http://hdl.handle.net/2445/184530
Publikováno v:
Stem Cell Research, Vol 20, Iss C, Pp 67-69 (2017)
Human fibroblast cells collected from a 3-year old, female Rett Syndrome patient with a 32 bp deletion in the X-linked MECP2 gene were obtained from the Coriell Institute. Fibroblasts were reprogrammed to iPSC cells using a Sendai-virus delivery syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698bca59edcc4968d96cd5d92fcb4501
Publikováno v:
Toxicology and Applied Pharmacology. 289:89-97
Pregnant rats treated with dimethadione (DMO), the N-demethylated metabolite of the anticonvulsant trimethadione, produce offspring having a 74% incidence of congenital heart defects (CHD); however, the incidence of CHD has high inter-litter variabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87591474eff51a4a21eacd9fb5aad45
https://doi.org/10.1016/j.taap.2015.09.005
https://doi.org/10.1016/j.taap.2015.09.005
Autor:
Martyn Banks, Andrea D. Weston, Lisa Elkin, Jonathan O’Connell, Debra Nickischer, Normand J. Cloutier
Publikováno v:
Methods in Molecular Biology ISBN: 9781493973552
Within the Drug Discovery industry, there is a growing recognition of the value of high content screening (HCS), particularly as researchers aim to screen compounds and identify hits using more physiologically relevant in vitro cell-based assays. Ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2773afaf4e6bf70a4e60829b2e3d6bde
https://doi.org/10.1007/978-1-4939-7357-6_11
https://doi.org/10.1007/978-1-4939-7357-6_11
Publikováno v:
Current Chemical Genomics and Translational Medicine
Microtubules are important components of the cellular cytoskeleton that play roles in various cellular processes such as vesicular transport and spindle formation during mitosis. They are formed by an ordered organization of α-tubulin and β-tubulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6724ff2d9b75340a83579ab42268b466
https://doi.org/10.2174/2213988501408010016
https://doi.org/10.2174/2213988501408010016
Publikováno v:
Birth Defects Research Part C: Embryo Today: Reviews. 78:354-370
Congenital heart defects (CHDs) are the most common birth defects in humans. In addition, cardiac malformations represent the most frequently identified anomaly in teratogenicity experiments with laboratory animals. To explore the mechanisms of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a9e56565714fc4e11c4cd0c757c67f
https://doi.org/10.1002/bdrc.20084
https://doi.org/10.1002/bdrc.20084
Autor:
Jennifer J. Smith, Alistair G. Rust, Andrea D. Weston, John D. Aitchison, Daehee Hwang, Hamid Bolouri, Leroy Hood, Andrew F. Siegel, Pedro de Atauri, Stephen A. Ramsey, Deena M. Leslie
Publikováno v:
Proceedings of the National Academy of Sciences. 102:17296-17301
Different experimental technologies measure different aspects of a system and to differing depth and breadth. High-throughput assays have inherently high false-positive and false-negative rates. Moreover, each technology includes systematic biases of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3252388b2f984ded34f25c1dcb5dd885
https://doi.org/10.1073/pnas.0508647102
https://doi.org/10.1073/pnas.0508647102
Autor:
and Andrea D. Weston, Leroy Hood
Publikováno v:
Journal of Proteome Research. 3:179-196
The emergence of systems biology is bringing forth a new set of challenges for advancing science and technology. Defining ways of studying biological systems on a global level, integrating large and disparate data types, and dealing with the infrastr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfe3c6ad3b125ea6a6364485cba3822
https://doi.org/10.1021/pr0499693
https://doi.org/10.1021/pr0499693