Výsledky vyhledávání - "Andrea D. Transou"

Akademický článek

Sox2 Promotes Malignancy in Glioblastoma by Regulating Plasticity and Astrocytic Differentiation

Autor: Artem D. Berezovsky, Laila M. Poisson, David Cherba, Craig P. Webb, Andrea D. Transou, Nancy W. Lemke, Xin Hong, Laura A. Hasselbach, Susan M. Irtenkauf, Tom Mikkelsen, Ana C. deCarvalho

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 3, Pp 193-206.e25 (2014)

The high-mobility group–box transcription factor sex-determining region Y–box 2 (Sox2) is essential for the maintenance of stem cells from early development to adult tissues. Sox2 can reprogram differentiated cells into pluripotent cells in conce

Externí odkaz: https://doaj.org/article/78a30655359940b59818745a8950f19a

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CSIG-06. PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA AS AN ONCOGENIC DRIVER IN GLIOBLASTOMA

Autor: Tom Mikkelsen, Susan Irtenkauf, Laura Hasselbach, Ana C de Carvalho, Andrea D. Transou, Artem D. Berezovsky

Publikováno v: Neuro Oncol

Activated platelet derived growth factor receptor alpha (PDGFRα) is essential for the maintenance of oligodendrocyte progenitors. Differential signaling results from phosphorylation of specific tyrosine residues in the kinase insert (KI) domain pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9836ed85326793dd445ea7cdb17094
https://europepmc.org/articles/PMC7651131/

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CSIG-10. PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA ONCOGENE DEPENDENCY IN GLIOBLASTOMA

Autor: Indrani Datta, Laila M. Poisson, Artem Berezovsky, Laura Hasselbach, Ana C. deCarvalho, Ruicong She, Andrea D. Transou, Susan Irtenkauf

Publikováno v: Neuro-Oncology. 23:vi35-vi35

PDGFRA is the second most frequently amplified gene encoding receptor tyrosine kinase in adult glioblastoma (GBM), oftentimes as extrachromosomal elements (ecDNA). Our overall objective is to elucidate mechanisms underlying PDGFRα dependency in GBM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::037fbe391242ebfd0d67758938a8e793
https://doi.org/10.1093/neuonc/noab196.136

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Anaplastic meningioma: octreotide therapy for a case of recurrent and progressive intracranial disease

Autor: Richard Rammo, Adam Rock, Jack Rock, Andrea D. Transou, Aditya Raghunathan

Publikováno v: Journal of Neurosurgery. 124:496-500

Meningiomas are common intracranial tumors categorized as Grades I–III per the current WHO guidelines. A small percentage of meningiomas are Grades II and III, which are likely to recur after initial treatment. Grade III meningiomas are considered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9481fd9b185cd639fe5a84087b8c9e5
https://doi.org/10.3171/2015.1.jns142260

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Abstract 1505: Platelet derived growth factor receptor alpha oncogene dependency in glioblastoma

Autor: Ana C. deCarvalho, Artem D. Berezovsky, Tom Mikkelsen, Andrea D. Transou, Laura Hasselbach, Susan M. Irtenkauf

Publikováno v: Cancer Research. 80:1505-1505

Platelet-derived growth factor receptor alpha (PDGFRA) is a ligand-activated receptor tyrosine kinase (RTK) involved in neurodevelopment. In pediatric and adult glioblastoma (GBM), PDGFRA downstream signaling promotes tumor cell proliferation, stemne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27c1e240e9e1bf0a3497f6a67558d922
https://doi.org/10.1158/1538-7445.am2020-1505

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P11.54 Identification of PDGFRA and MYC(N) as somatic driver genes in Glioblastoma

Autor: Ana C deCarvalho, T. Mikkelsen, Andrea D. Transou, K Hank Wu, Artem Berezovsky, Susan Irtenkauf, Laila M. Poisson

Publikováno v: Neuro Oncol

BACKGROUND Somatic oncogene amplification happens frequently in glioblastoma (GBM). The second most frequently amplified gene encoding receptor tyrosine kinases in GBMs is platelet derived growth factor alpha (PDGFRA) (15%). In contrast, MYC and MYCN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857e012666ae73b034778a990fedebba
https://doi.org/10.1093/neuonc/noz126.200

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TMOD-06. HIGH INCIDENCE OF TUMORS AFTER TREATMENT WITH A DNA-ALKYLATING AGENT IN MOUSE STRAINS COMMONLY USED IN PRE-CLINICAL STUDIES

Autor: Ana C. deCarvalho, Igor I. Rybkin, Houtan Noushmehr, Susan Irtenkauf, Andrea D. Transou, Laura Hasselbach, Laila M. Poisson

Publikováno v: Neuro-Oncology. 20:vi269-vi269

Glioblastoma (GBM) is commonly treated with the DNA-alkylating agent temozolomide (TMZ). Silencing O6-methylguanine-DNA methyltransferase (MGMT) by promoter hypermethylation predicts response to TMZ. Oral TMZ administration also affects tissues with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ef770895ca25730b8587824a9a578c
https://doi.org/10.1093/neuonc/noy148.1119

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Abstract 3491: Heterogeneous extrachromosomal amplification of mutant PDGFRA is associated with an aggressive phenotype in glioblastoma

Autor: Andrea D. Transou, Susan Irtenkauf, Ana C. deCarvalho, Artem D. Berezovsky, Laila M. Poisson, Tom Mikkelsen, Hoon Kim, Julie Koeman, Laura Hasselbach, Roel G.W. Verhaak

Publikováno v: Cancer Research. 78:3491-3491

Background & Objective: Receptor tyrosine kinase (RTK) signaling is altered in over 80% of glioblastoma (GBM) cases, frequently through gene amplification. About 14% of GBMs carry amplification in the gene coding for platelet-derived growth factor re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2fe0582e20888b89046b8996fefa3e4
https://doi.org/10.1158/1538-7445.am2018-3491

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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Autor: Artem D. Berezovsky, Nancy Lemke, Tom Mikkelsen, Ana C. deCarvalho, Andrea D. Transou, Enoch T. Carlton, Kevin Nelson, Laura Hasselbach, Susan M. Irtenkauf

Publikováno v: Journal of Visualized Experiments : JoVE

Glioblastomas, the most common and aggressive form of astrocytoma, are refractory to therapy, and molecularly heterogeneous. The ability to establish cell cultures that preserve the genomic profile of the parental tumors, for use in patient specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407b0c59f073c0c0757e1f12f76945a9
https://doi.org/10.3791/51088

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Sox2 Promotes Malignancy in Glioblastoma by Regulating Plasticity and Astrocytic Differentiation

Autor: Ana C. deCarvalho, Xin Hong, Andrea D. Transou, Laura Hasselbach, Tom Mikkelsen, Susan M. Irtenkauf, Nancy Lemke, Craig P. Webb, Artem D. Berezovsky, Laila M. Poisson, David Cherba

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 3, Pp 193-206.e25 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1735b3b1b9fcc548b6547f2a71d1bd4
https://doi.org/10.1016/j.neo.2014.03.006

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