Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Andrea Cuconati"'
Autor:
Angela M. Lam, Ravi R. Dugyala, Muhammed Sheraz, Fei Liu, Emily P. Thi, Ingrid E. Graves, Andrea Cuconati, Holly Micolochick Steuer, Andrzej Ardzinski, Nathan Overholt, Jeremy D. Mason, Dimitar Gotchev, Andrew G. Cole, Troy O. Harasym, Michael J. Sofia
Publikováno v:
Viruses, Vol 16, Iss 3, p 323 (2024)
HBV RNA destabilizers are a class of small-molecule compounds that target the noncanonical poly(A) RNA polymerases PAPD5 and PAPD7, resulting in HBV RNA degradation and the suppression of viral proteins including the hepatitis B surface antigen (HBsA
Externí odkaz:
https://doaj.org/article/0908b4ef0b784f98b382f882d0593288
Autor:
Fang Guo, Qiong Zhao, Muhammad Sheraz, Junjun Cheng, Yonghe Qi, Qing Su, Andrea Cuconati, Lai Wei, Yanming Du, Wenhui Li, Jinhong Chang, Ju-Tao Guo
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006658 (2017)
Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (
Externí odkaz:
https://doaj.org/article/bc3ceaf2ed8e4d57b80f75484972132c
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129889 (2015)
Hepatitis B virus (HBV) infection and its sequelae remain a major public health burden, but both HBV basic research and the development of antiviral therapeutics have been hindered by the lack of an efficient in vitro infection system. Recently, sodi
Externí odkaz:
https://doaj.org/article/49581340ffa145489d4a301a878962eb
Autor:
Richeng Mao, Hui Nie, Dawei Cai, Jiming Zhang, Hongyan Liu, Ran Yan, Andrea Cuconati, Timothy M Block, Ju-Tao Guo, Haitao Guo
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003494 (2013)
The zinc finger antiviral protein (ZAP) is a mammalian host restriction factor that inhibits the replication of a variety of RNA viruses, including retroviruses, alphaviruses and filoviruses, through interaction with the ZAP-responsive elements (ZRE)
Externí odkaz:
https://doaj.org/article/b956cc1cfd8f4d589f15cd735a0f6f27
Autor:
Andrea Cuconati, Courtney Mills, Cally Goddard, Xianchao Zhang, Wenquan Yu, Haitao Guo, Xiaodong Xu, Timothy M Block
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54595 (2013)
Hepatocellular carcinoma (HCC) is the third most common cause of cancer fatalities worldwide, with limited treatment options and five year survival rates of between 50% growth inhibition by HBF-0079. In Huh7 cells, HBF-0079 induced cell cycle arrest
Externí odkaz:
https://doaj.org/article/20590d34c4394cd5a5726ce797740b0d
Autor:
Fang Guo, Jennifer Mead, Nishat Aliya, Lijuan Wang, Andrea Cuconati, Lai Wei, Kui Li, Timothy M Block, Ju-Tao Guo, Jinhong Chang
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e42583 (2012)
Recognition of virus infection by innate pattern recognition receptors (PRRs), including membrane-associated toll-like receptors (TLR) and cytoplasmic RIG-I-like receptors (RLR), activates cascades of signal transduction pathways leading to productio
Externí odkaz:
https://doaj.org/article/27d2e9c8595d4ed0bdd059bbbbceada1
Autor:
Qiong Zhao, Jinhong Chang, Rene Rijnbrand, Angela M. Lam, Michael J. Sofia, Andrea Cuconati, Ju-Tao Guo
Publikováno v:
J Virol
Hepatitis B virus (HBV) replicates its genomic DNA by reverse transcription of an RNA intermediate, termed pregenomic RNA (pgRNA), within nucleocapsid. It had been shown that transfection of in vitro-transcribed pgRNA initiated viral replication in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bb3fe2264d6144d5543149dcb23a78
https://pubmed.ncbi.nlm.nih.gov/36448800
https://pubmed.ncbi.nlm.nih.gov/36448800
Autor:
Kristi Fan, Andrea Cuconati, Robbin Burns, Xiaowei Teng, Amy C.H. Lee, Nagraj Mani, Ellen Evangelista, Bruce D. Dorsey, Sunny Tang, Salam Kadhim, Roseann Kowalski, Angela Miller, Troy Harasym, Janet R. Phelps, Kim Stever, Andrzej Ardzinski, Alice H. Li, Chris Pasetka, Rene Rijnbrand, Andrew G. Cole, Holly M. Micolochick Steuer, Stephen P. Reid, Steven G. Kultgen, Michael J. Sofia, Xiaohe Wang, Tim T. Chiu, Sara A. Majeski, Fang Guo
Publikováno v:
Antiviral research. 197
AB-506, a small-molecule inhibitor targeting the HBV core protein, inhibits viral replication in vitro (HepAD38 cells: EC50 of 0.077 μM, CC50 > 25 μM) and in vivo (HBV mouse model: ∼3.0 log10 reductions in serum HBV DNA compared to the vehicle co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39029ab6adc8f539c39058419e8ea3e4
https://pubmed.ncbi.nlm.nih.gov/34826506
https://pubmed.ncbi.nlm.nih.gov/34826506
Autor:
Jinhong Chang, Xuexiang Zhang, Shuo Wu, Andrea Cuconati, Yanming Du, Ju-Tao Guo, Justin G. Julander, John L. Kulp, Timothy M. Block, Julia Ma, Fang Guo
Publikováno v:
Journal of Virology
Animal, Dairy, and Veterinary Science Faculty Publications
Animal, Dairy, and Veterinary Science Faculty Publications
Although a highly effective vaccine is available, the number of yellow fever cases has increased over the past 2 decades, which highlights the pressing need for antiviral therapeutics. In a high-throughput screening campaign, we identified an acetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab8db9e8c9b80da696eb32571d3431f
Autor:
Alice H. L. Li, Xiaohe Wang, Andrew S. Kondratowicz, Chris Pasetka, Janet R. Phelps, Michael J. Sofia, Nicholas M. Snead, Ammen P. Dhillon, Kaylyn Kwak, Andrzej Ardzinski, Kyle D. Cobarrubias, Xin Ye, Andrea Cuconati, Luying Pei, Angela Miller, Lale Bidirici-Ertekin, Amy C.H. Lee, Emily P. Thi
Publikováno v:
ACS infectious diseases. 5(5)
Current approved nucleoside analogue treatments for chronic hepatitis B virus (HBV) infection are effective at controlling viral titer but are not curative and have minimal impact on the production of viral proteins such as surface antigen (HBsAg), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284884f962cca651c5d79ac5cda2daa6
https://pubmed.ncbi.nlm.nih.gov/30403127
https://pubmed.ncbi.nlm.nih.gov/30403127