Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrea Citarella"'
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 1031 (2024)
Oxidative stress is a key factor in the pathological processes that trigger various chronic liver diseases, and significantly contributes to the development of hepatocarcinogenesis. Natural antioxidants reduce oxidative stress by neutralizing free ra
Externí odkaz:
https://doaj.org/article/cc4a384e2c2c412cba389c0ac854f43d
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
This comprehensive review, covering 2021–2023, explores the multifaceted chemical and pharmacological potential of coumarins, emphasizing their significance as versatile natural derivatives in medicinal chemistry. The synthesis and functionalizatio
Externí odkaz:
https://doaj.org/article/b942001313de4bc5b214e184fb6587b9
Autor:
Andrea Citarella, Alessandro Dimasi, Davide Moi, Daniele Passarella, Angela Scala, Anna Piperno, Nicola Micale
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1339 (2023)
The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target. Disruption of the catalytic activity of Mpro produces a detrimental ef
Externí odkaz:
https://doaj.org/article/00eeeba6b2bc47d191e6df9db6aefe8d
Publikováno v:
ACS Omega, Vol 6, Iss 34, Pp 21843-21849 (2021)
Externí odkaz:
https://doaj.org/article/35cb15fe9cdc42febac54efebc4f67d9
Autor:
Enrico M. A. Fassi, Marco Manenti, Andrea Citarella, Michele Dei Cas, Sara Casati, Nicola Micale, Tanja Schirmeister, Gabriella Roda, Alessandra Silvani, Giovanni Grazioso
Publikováno v:
Molecules, Vol 28, Iss 5, p 2356 (2023)
The COVID-19 pandemic has given a strong impetus to the search for antivirals active on SARS-associated coronaviruses. Over these years, numerous vaccines have been developed and many of these are effective and clinically available. Similarly, small
Externí odkaz:
https://doaj.org/article/8f09dc5c157241ebbceaacde68e34aae
Autor:
Andrea Citarella, Davide Moi, Martina Pedrini, Helena Pérez-Peña, Stefano Pieraccini, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Daniele Passarella, Clelia Giannini
Publikováno v:
Molecules, Vol 28, Iss 2, p 514 (2023)
SARS-CoV-2 Mpro is a chymotrypsin-like cysteine protease playing a relevant role during the replication and infectivity of SARS-CoV-2, the coronavirus responsible for COVID-19. The binding site of Mpro is characterized by the presence of a catalytic
Externí odkaz:
https://doaj.org/article/fd5e75a5ccd442329d507b6342d1c2af
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15960 (2022)
In the panorama of sustainable chemistry, the use of green solvents is increasingly emerging for the optimization of more eco-friendly processes which look to a future of biocompatibility and recycling. The green solvent Cyrene, obtained from biomass
Externí odkaz:
https://doaj.org/article/2d3bb69c384b4565900857eb54e8a443
Autor:
Laura Ielo, Vincenzo Patamia, Andrea Citarella, Thomas Efferth, Nasim Shahhamzehei, Tanja Schirmeister, Claudio Stagno, Thierry Langer, Antonio Rescifina, Nicola Micale, Vittorio Pace
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12363 (2022)
The ubiquitin-proteasome pathway (UPP) is the major proteolytic system in the cytosol and nucleus of all eukaryotic cells. The role of proteasome inhibitors (PIs) as critical agents for regulating cancer cell death has been established. Aziridine der
Externí odkaz:
https://doaj.org/article/5889b17e0c9e41f8a8d53ced6ac02485
Autor:
Nicola Micale, Maria Sofia Molonia, Andrea Citarella, Francesco Cimino, Antonina Saija, Mariateresa Cristani, Antonio Speciale
Publikováno v:
Molecules, Vol 26, Iss 15, p 4665 (2021)
One of the main current strategies for cancer treatment is represented by combination chemotherapy. More recently, this strategy shifted to the “hybrid strategy”, namely the designing of a new molecular entity containing two or more biologically
Externí odkaz:
https://doaj.org/article/3b6bde898d0f4fb6a430fb5715c62d13
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 607 (2021)
The uncontrolled spread of the COVID-19 pandemic caused by the new coronavirus SARS-CoV-2 during 2020–2021 is one of the most devastating events in the history, with remarkable impacts on the health, economic systems, and habits of the entire world
Externí odkaz:
https://doaj.org/article/00808a5b6fb44a1982f7aa9b5aa77015