Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Andrea Ciliberto"'
Autor:
Mattia Pavani, Elena Chiroli, Camilla Cancrini, Fridolin Gross, Paolo Bonaiuti, Stefano Villa, Fabio Giavazzi, Vittoria Matafora, Angela Bachi, Luca L. Fava, Tiziana Lischetti, Andrea Ciliberto
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112215- (2023)
Summary: Drugs targeting microtubules rely on the mitotic checkpoint to arrest cell proliferation. The prolonged mitotic arrest induced by such drugs is followed by a G1 arrest. Here, we follow for several weeks the fate of G1-arrested human cells af
Externí odkaz:
https://doaj.org/article/63be34cdd8944fb8a7ad24b0ae51f05d
Autor:
Anita Alexa, Péter Sok, Fridolin Gross, Krisztián Albert, Evan Kobori, Ádám L. Póti, Gergő Gógl, Isabel Bento, Ersheng Kuang, Susan S. Taylor, Fanxiu Zhu, Andrea Ciliberto, Attila Reményi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The herpesvirus protein ORF45 can bind the two host kinases ERK and RSK but how this affects cell signalling is unclear. Here, the authors show that ORF45 hijacks the ERK-RSK complex by binding to the two kinases with optimized linear motifs and inte
Externí odkaz:
https://doaj.org/article/b1961af753104939b45873b5e2d5dcfc
Autor:
Richard J. Smith, Marilia H. Cordeiro, Norman E. Davey, Giulia Vallardi, Andrea Ciliberto, Fridolin Gross, Adrian T. Saurin
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2206-2219.e8 (2019)
Summary: PP1 and PP2A-B56 are major serine/threonine phosphatase families that achieve specificity by colocalizing with substrates. At the kinetochore, however, both phosphatases localize to an almost identical molecular space and yet they still mana
Externí odkaz:
https://doaj.org/article/56be128601e84e0e9b4e4487d4343491
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 9, p e1006449 (2018)
The mitotic checkpoint (also called spindle assembly checkpoint) is a signaling pathway that ensures faithful chromosome segregation. Mitotic checkpoint proteins inhibit the anaphase-promoting complex (APC/C) and its activator Cdc20 to prevent precoc
Externí odkaz:
https://doaj.org/article/39e9851e9eab4571b7932a1d266956e5
Autor:
Andrea Ciliberto, Silke Hauf
Publikováno v:
eLife, Vol 6 (2017)
The kinase Mps1, long known to be the ‘boss’ in mitotic checkpoint signaling, phosphorylates multiple proteins in the checkpoint signaling cascade.
Externí odkaz:
https://doaj.org/article/229cf6d813b643b1860795344c4ec581
Autor:
Ivana Primorac, John R Weir, Elena Chiroli, Fridolin Gross, Ingrid Hoffmann, Suzan van Gerwen, Andrea Ciliberto, Andrea Musacchio
Publikováno v:
eLife, Vol 2 (2013)
Regulation of macromolecular interactions by phosphorylation is crucial in signaling networks. In the spindle assembly checkpoint (SAC), which enables errorless chromosome segregation, phosphorylation promotes recruitment of SAC proteins to tensionle
Externí odkaz:
https://doaj.org/article/66a6b5113ddb4ac7aceb2f6192a11fb9
Autor:
Federico Vaggi, Andrea Disanza, Francesca Milanesi, Pier Paolo Di Fiore, Elisabetta Menna, Michela Matteoli, Nir S Gov, Giorgio Scita, Andrea Ciliberto
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 7, p e1002088 (2011)
There is a body of literature that describes the geometry and the physics of filopodia using either stochastic models or partial differential equations and elasticity and coarse-grained theory. Comparatively, there is a paucity of models focusing on
Externí odkaz:
https://doaj.org/article/b68d4bc1cbf4406c94c786b5380e4b0c
Autor:
Marco Simonetta, Romilde Manzoni, Roberto Mosca, Marina Mapelli, Lucia Massimiliano, Martin Vink, Bela Novak, Andrea Musacchio, Andrea Ciliberto
Publikováno v:
PLoS Biology, Vol 7, Iss 1, p e10 (2009)
Mad2 is a key component of the spindle assembly checkpoint, a safety device ensuring faithful sister chromatid separation in mitosis. The target of Mad2 is Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C). Mad2 binding to Cdc20
Externí odkaz:
https://doaj.org/article/dfa77e6f68c7488393590553a7ab1ca3
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 3, p e45 (2007)
In metabolic networks, metabolites are usually present in great excess over the enzymes that catalyze their interconversion, and describing the rates of these reactions by using the Michaelis-Menten rate law is perfectly valid. This rate law assumes
Externí odkaz:
https://doaj.org/article/6427906e884540569b6eaa43c7c5dc93
Autor:
Robert Jaster, Boris Zhivotovsky, Michael White, Julio Vera, John Tyson, Darryl Shibata, Santiago Schnell, Christine Sers, Karsten Schürrle, Reinhold Schäfer, Owen Sansom, Katja Rateitschak, Arif Malik, Philip K. Maini, John Lowengrub, Michael Linnebacher, Francis Levi, Philippe Lenormand, Ingeborg van Leeuwen, Manfred Kunz, Christian Junghanss, Hanspeter Herzel, Brian D. Harms, Ulrich Günther, Robert Gatenby, Daniel Gallahan, James E. Ferrell, David Fell, Dirk Drasdo, Trevor Dale, Andrea Ciliberto, Marta Cascante, Helen Byrne, Nils Blüthgen, Simone Baltrusch, Charles Auffray, Olaf Wolkenhauer
Free Article from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fa03f4c190405f46f26a2cd794d706
https://doi.org/10.1158/0008-5472.22383345.v1
https://doi.org/10.1158/0008-5472.22383345.v1
