Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Andrea Cerase"'
Autor:
Andrea Cerase, Philip Avner
Publikováno v:
Current Research in Neurobiology, Vol 5, Iss , Pp 100114- (2023)
The chromodomain helicase DNA-binding protein 8 (CHD8) is a chromatin remodeler whose mutation is associated, with high penetrance, with autism. Individuals with CHD8 mutations share common symptoms such as autistic behaviour, cognitive impairment, s
Externí odkaz:
https://doaj.org/article/ecaf1beaaa3045cc96c08091981cc9fa
Publikováno v:
Frontiers in Earth Science, Vol 10 (2022)
Large-scale coastal urban sprawl, development of tourist accommodations and industrial maritime poles have highly increased the tsunami risk to people living and/or traveling along the coasts of our planet. The disastrous tsunamis in the Indian Ocean
Externí odkaz:
https://doaj.org/article/d173578c99794a4fb9e8d1c2b8ba512e
Autor:
Andrea Cerase, Alexander N. Young, Nerea Blanes Ruiz, Andreas Buness, Gabrielle M. Sant, Mirjam Arnold, Monica Di Giacomo, Michela Ascolani, Manish Kumar, Andreas Hierholzer, Giuseppe Trigiante, Sarah J. Marzi, Philip Avner
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cel
Externí odkaz:
https://doaj.org/article/d26e720a693341bcb6cd62cfbe1b421b
Autor:
Alexander Neil Young, Emerald Perlas, Nerea Ruiz-Blanes, Andreas Hierholzer, Nicola Pomella, Belen Martin-Martin, Alessandra Liverziani, Joanna W. Jachowicz, Thomas Giannakouros, Andrea Cerase
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Young et al. report a new mouse model for Pelger-Huet anomaly, a genetic disorder caused by mutations in the Lamin B receptor gene (Lbr) that leads to abnormal neutrophil differentiation and skeletal defects. Using CRISPR/Cas-9 editing of Lbr, which
Externí odkaz:
https://doaj.org/article/a0388b7db1f045ad87ee722dcc675a86
Autor:
Hyeong-Min Lee, M. Bram Kuijer, Nerea Ruiz Blanes, Ellen P. Clark, Megumi Aita, Lorena Galiano Arjona, Agnieszka Kokot, Noah Sciaky, Jeremy M. Simon, Sanchita Bhatnagar, Benjamin D. Philpot, Andrea Cerase
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 12, Iss 1, Pp 1-11 (2020)
Abstract Background Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MeCP2) gene. While MeCP2 mutations are lethal in most males, females survive birth but show severe neurological
Externí odkaz:
https://doaj.org/article/f1d6c74a535f4002b4d27d4a54f485ae
Autor:
Irene Nepita, Simonluca Piazza, Martina Ruglioni, Sofia Cristiani, Emanuele Bosurgi, Tiziano Salvadori, Giuseppe Vicidomini, Alberto Diaspro, Marco Castello, Andrea Cerase, Paolo Bianchini, Barbara Storti, Ranieri Bizzarri
Publikováno v:
Biology, Vol 12, Iss 3, p 374 (2023)
The genomes of metazoans are organized at multiple spatial scales, ranging from the double helix of DNA to whole chromosomes. The intermediate genomic scale of kilobases to megabases, which corresponds to the 50–300 nm spatial scale, is particularl
Externí odkaz:
https://doaj.org/article/c71ee9adc9524f05a9f91aa573346f1e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Genomic repeats have been intensely studied as regulatory elements controlling gene transcription, splicing and genome architecture. Our understanding of the role of the repetitive RNA such as the RNA coming from genomic repeats, or repetitive sequen
Externí odkaz:
https://doaj.org/article/3ff56946347a4608b867e4338d01ef3f
Autor:
Andrea Cerase, Gian Gaetano Tartaglia
Publikováno v:
Open Biology, Vol 10, Iss 9 (2020)
The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-li
Externí odkaz:
https://doaj.org/article/8db2c968860349be976831ebd17a6cba
Publikováno v:
Non-Coding RNA, Vol 7, Iss 2, p 36 (2021)
Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression o
Externí odkaz:
https://doaj.org/article/25e0d59efde647a782f67665057f0a56
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
Recent experimental evidence indicates that lncRNAs can act as regulatory molecules in the context of development and disease. Xist, the master regulator of X chromosome inactivation, is a classic example of how lncRNAs can exert multi-layered and fi
Externí odkaz:
https://doaj.org/article/f93f2fc8d59a4c09a09cc638d79e80af