Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Andrea Caricasole"'
Autor:
Valeria Mannella, Linda Chaabane, Tamara Canu, Alan Zanardi, Sara Raia, Antonio Conti, Barbara Ferrini, Andrea Caricasole, Giovanna Musco, Massimo Alessio
Publikováno v:
FEBS Open Bio, Vol 14, Iss 2, Pp 258-275 (2024)
Ceruloplasmin (Cp) is a ferroxidase that plays a role in cellular iron homeostasis and is mainly expressed in the liver and secreted into the blood. Cp is also produced by adipose tissue, which releases it as an adipokine. Although a dysfunctional in
Externí odkaz:
https://doaj.org/article/7bb64e28fecd4037b386971e41ba78a6
Autor:
Alan Zanardi, Ilaria Nardini, Sara Raia, Antonio Conti, Barbara Ferrini, Patrizia D’Adamo, Enrica Gilberti, Giuseppe DePalma, Sara Belloli, Cristina Monterisi, Angela Coliva, Paolo Rainone, Rosa Maria Moresco, Filippo Mori, Giada Zurlo, Carla Scali, Letizia Natali, Annalisa Pancanti, Pierangelo Giovacchini, Giulio Magherini, Greta Tovani, Laura Salvini, Vittoria Cicaloni, Cristina Tinti, Laura Tinti, Daniele Lana, Giada Magni, Maria Grazia Giovannini, Alessandro Gringeri, Andrea Caricasole, Massimo Alessio
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Plasma-derived therapeutic proteins are produced through an industrial fractionation process where proteins are purified from individual intermediates, some of which remain unused and are discarded. Relatively few plasma-derived proteins are
Externí odkaz:
https://doaj.org/article/a70a2b7493df422985c817e4817d1cb4
Autor:
Giulia Birolini, Marta Valenza, Eleonora Di Paolo, Elena Vezzoli, Francesca Talpo, Claudia Maniezzi, Claudio Caccia, Valerio Leoni, Franco Taroni, Vittoria D Bocchi, Paola Conforti, Elisa Sogne, Lara Petricca, Cristina Cariulo, Margherita Verani, Andrea Caricasole, Andrea Falqui, Gerardo Biella, Elena Cattaneo
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-20 (2020)
Abstract A variety of pathophysiological mechanisms are implicated in Huntington's disease (HD). Among them, reduced cholesterol biosynthesis has been detected in the HD mouse brain from pre‐symptomatic stages, leading to diminished cholesterol syn
Externí odkaz:
https://doaj.org/article/89f06c9b7c8d4934b2e0285e4e423d49
Autor:
Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández, Rogan A. Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A. Ross, Udai B. Pandey, José J. Lucas, Frédéric Saudou, Maria Pennuto, Manuela Basso
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108980- (2021)
Summary: The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disru
Externí odkaz:
https://doaj.org/article/4ec24cea628a418d9972d9f2b7afcdb5
Autor:
Manuel Daldin, Valentina Fodale, Cristina Cariulo, Lucia Azzollini, Margherita Verani, Paola Martufi, Maria Carolina Spiezia, Sean M. Deguire, Marta Cherubini, Douglas Macdonald, Andreas Weiss, Alberto Bresciani, Jean-Paul Gerard Vonsattel, Lara Petricca, J. Lawrence Marsh, Silvia Gines, Iolanda Santimone, Massimo Marano, Hilal A. Lashuel, Ferdinando Squitieri, Andrea Caricasole
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Conformational changes in disease-associated or mutant proteins represent a key pathological aspect of Huntington’s disease (HD) and other protein misfolding diseases. Using immunoassays and biophysical approaches, we and others have recen
Externí odkaz:
https://doaj.org/article/28a4ca589dda4cb5b33f36313fe3c9c6
Autor:
Cristina Cariulo, Paola Martufi, Margherita Verani, Lucia Azzollini, Giordana Bruni, Andreas Weiss, Sean M. Deguire, Hilal A. Lashuel, Eugenia Scaricamazza, Giulia Maria Sancesario, Tommaso Schirinzi, Nicola Biagio Mercuri, Giuseppe Sancesario, Andrea Caricasole, Lara Petricca
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Accumulation and aggregation of misfolded alpha-synuclein is believed to be a cause of Parkinson’s disease (PD). Phosphorylation of alpha-synuclein at S129 is known to be associated with the pathological misfolding process, but efforts to investiga
Externí odkaz:
https://doaj.org/article/1fd0919526c9414b8d75d8867779eee4
Autor:
Ilaria Ceccarelli, Pasquale Fiengo, Rosaria Remelli, Vincenzo Miragliotta, Lara Rossini, Irene Biotti, Alessandra Cappelli, Lara Petricca, Salvatore La Rosa, Andrea Caricasole, Giuseppe Pollio, Carla Scali
Publikováno v:
Neurobiology of Disease, Vol 86, Iss , Pp 41-51 (2016)
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by dyskinesia, cognitive impairment and emotional disturbances, presenting progressive neurodegeneration in the striatum and intracellular mutant Huntingtin (mHTT) agg
Externí odkaz:
https://doaj.org/article/5136348a3c0f4834842090aefe3064de
Autor:
Giuseppe Pollio, Jeroen J.M. Hoozemans, Claus A. Andersen, Renza Roncarati, Maria Cristina Rosi, Elise S. van Haastert, Tamara Seredenina, Daniela Diamanti, Stefano Gotta, Anna Fiorentini, Letizia Magnoni, Roberto Raggiaschi, Annemieke J.M. Rozemuller, Fiorella Casamenti, Andrea Caricasole, Georg C. Terstappen
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 1, Pp 145-158 (2008)
In a comprehensive proteomics study aiming at the identification of proteins associated with amyloid-beta (Aβ)-mediated toxicity in cultured cortical neurons, we have identified Thimet oligopeptidase (THOP1). Functional modulation of THOP1 levels in
Externí odkaz:
https://doaj.org/article/f395872d345c4193af394d962f5995fb
Autor:
Carla Scali, Filippo Caraci, Marco Gianfriddo, Enrica Diodato, Renza Roncarati, Giuseppe Pollio, Giovanni Gaviraghi, Agata Copani, Ferdinando Nicoletti, Georg C. Terstappen, Andrea Caricasole
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 254-265 (2006)
Expression of the Wnt antagonist Dickkopf-1 (DKK1) is induced during neurodegenerative processes associated with Alzheimer's Disease and brain ischemia. However, little is known about DKK1-mediated effects on neurons. We now describe that, in culture
Externí odkaz:
https://doaj.org/article/961a1ad2de92453984cd0009a2e55199
Autor:
Valentina Fodale, Natalie C Kegulian, Margherita Verani, Cristina Cariulo, Lucia Azzollini, Lara Petricca, Manuel Daldin, Roberto Boggio, Alessandro Padova, Rainer Kuhn, Robert Pacifici, Douglas Macdonald, Ryan C Schoenfeld, Hyunsun Park, J Mario Isas, Ralf Langen, Andreas Weiss, Andrea Caricasole
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e112262 (2014)
BACKGROUND:In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregat
Externí odkaz:
https://doaj.org/article/4a6d9360eb37452db5d79a45e783c38e