Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andrea C. Klaver"'
Publikováno v:
Translational Neurodegeneration, Vol 6, Iss 1, Pp 1-9 (2017)
Abstract Background Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies might slow the developm
Externí odkaz:
https://doaj.org/article/40d2e7973ff847a48c5316f18d5bd11b
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Autophagy removes both functional and damaged intracellular macromolecules from cells via lysosomal degradation. Three autophagic mechanisms, namely macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy, have been described in mammal
Externí odkaz:
https://doaj.org/article/cb89f995a6e3466aaeb145d020703310
Autor:
Amanda C. Crisostomo, Loan Dang, Jyothi L. Digambaranath, Andrea C. Klaver, David A. Loeffler, Jeremiah J. Payne, Lynnae M. Smith, Adam L. Yokom, John M. Finke
Publikováno v:
Data in Brief, Vol 4, Iss C, Pp 650-658 (2015)
The data here consists of time-dependent experimental parameters from chemical and biophysical methods used to characterize Aβ monomeric reactants as well as soluble oligomer and amyloid fibril products from a slow (3–4 week) assembly reaction und
Externí odkaz:
https://doaj.org/article/70189ab93d914f0ea3b12dee76f4bd0a
Publikováno v:
Brain Research. 1683:12-16
Lysosome-associated membrane glycoprotein 2 (lamp2) plays critical roles in chaperone-mediated autophagy (CMA) and macroautophagy. Its isoform lamp2a is decreased in Parkinson’s disease (PD) substantia nigra. Mutations in the leucine-rich repeat ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db263d43371ea61aebb9dbf41abb4f8
https://doi.org/10.1016/j.brainres.2018.01.016
https://doi.org/10.1016/j.brainres.2018.01.016
Publikováno v:
Translational Neurodegeneration, Vol 6, Iss 1, Pp 1-9 (2017)
Translational Neurodegeneration
Translational Neurodegeneration
Background Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies might slow the development and/o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc57d8679e392f3a3befc4cbb5bc1315
http://link.springer.com/article/10.1186/s40035-017-0100-x
http://link.springer.com/article/10.1186/s40035-017-0100-x
Autor:
David A. Loeffler, Andrea C. Klaver
Publikováno v:
International Immunopharmacology. 52:227-229
Specific antibody concentrations are frequently measured in serum (and plasma and intravenous immunoglobulin) samples by enzyme-linked immunosorbent assay (ELISA). The standard negative control involves incubation of buffer alone on antigen-coated we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fdebf0d08364357e9a191ef5ea2e66
https://doi.org/10.1016/j.intimp.2017.09.016
https://doi.org/10.1016/j.intimp.2017.09.016
Publikováno v:
International Immunopharmacology. 28:1108-1112
The therapeutic effects of intravenous immunoglobulin (IVIG) products were recently studied in Alzheimer's disease (AD) patients. Pilot studies produced encouraging results but phase II and III trials gave disappointing results; a further study is in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c71d600e224e89b050a3f7c8a0ffb8
https://doi.org/10.1016/j.intimp.2015.08.022
https://doi.org/10.1016/j.intimp.2015.08.022
Autor:
John M. Finke, Lynnae M. Smith, David A. Loeffler, Loan Dang, Adam L. Yokom, Amanda C. Crisostomo, Jeremiah J. Payne, Jyothi L. Digambaranath, Andrea C. Klaver
Publikováno v:
Data in Brief
Data in Brief, Vol 4, Iss C, Pp 650-658 (2015)
Data in Brief, Vol 4, Iss C, Pp 650-658 (2015)
The data here consists of time-dependent experimental parameters from chemical and biophysical methods used to characterize Aβ monomeric reactants as well as soluble oligomer and amyloid fibril products from a slow (3–4 week) assembly reaction und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963d9127e70314edf466791d06173849
http://europepmc.org/articles/PMC4560727
http://europepmc.org/articles/PMC4560727
Publikováno v:
Experimental Gerontology. 67:15-18
Phosphorylation of multiple amino acids on tau protein (“hyperphosphorylation”) is required for the development of tau pathology in Alzheimer's disease. Administration of anti-tau antibodies to transgenic “tauopathy mice” has been shown to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83af505404e6e4bc79b0a9d5b8d55d74
https://doi.org/10.1016/j.exger.2015.04.010
https://doi.org/10.1016/j.exger.2015.04.010
Autor:
Adam L. Yokom, Lynnae M. Smith, Amanda C. Crisostomo, Andrea C. Klaver, Jyothi L. Digambaranath, Loan Dang, David A. Loeffler, Jeremiah J. Payne, John M. Finke
Publikováno v:
Analytical Biochemistry. 481:43-54
Surface plasmon resonance was used to investigate the kinetics, affinity, and specificity of binding between anti-Aβ (beta-amyloid) IgG antibodies and oligomeric Aβ. Two factors were needed to accurately characterize the IgG binding kinetics. First
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8c0616e4a79afd7589195216ba60f4
https://doi.org/10.1016/j.ab.2015.03.032
https://doi.org/10.1016/j.ab.2015.03.032