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Autor:
Jochen Heukeshoven, Birgit Schäfer, Dorian Bevec, Andrea Bunk, Arne Düsedau, Joachim Hauber, Ilona Hauber
Publikováno v:
The Journal of infectious diseases. 194(6)
S-adenosylmethionine decarboxylase (SAMDC), a key enzyme in polyamine biosynthesis, can be specifically inhibited by the experimental drug SAM486A. The pharmaceutical interference with SAMDC activity results in the depletion of the intracellular pool