Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Andrea Bonetto"'
Autor:
Adeline Dolly, Sarah A. Pötgens, Morgane M. Thibaut, Audrey M. Neyrinck, Gabriela S. deCastro, Chloé Galbert, Camille Lefevre, Elisabeth Wyart, Silvio P. Gomes, Daniela C. Gonçalves, Nicolas Lanthier, Pamela Baldin, Joshua R. Huot, Andrea Bonetto, Marília Seelaender, Nathalie M. Delzenne, Harry Sokol, Laure B. Bindels
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1569-1582 (2023)
Abstract Background The aryl hydrocarbon receptor (AHR) is expressed in the intestine and liver, where it has pleiotropic functions and target genes. This study aims to explore the potential implication of AHR in cancer cachexia, an inflammatory and
Externí odkaz:
https://doaj.org/article/5bc931a787c441b1b90f54ab9bc830c5
Autor:
Alexander J. Jones, Leah J. Novinger, Andrea Bonetto, Kyle P. Davis, Marelle M. Giuliano, Avinash V. Mantravadi, Michael W. Sim, Michael G. Moore, Jessica A. Yesensky
Publikováno v:
International Journal of Surgical Oncology, Vol 2024 (2024)
Objective. Determine the histopathologic features that correlate with head and neck cancer (HNC) cachexia. Methods. A single-institution, retrospective study was performed on adults with HPV-negative, mucosal squamous cell carcinoma of the aerodigest
Externí odkaz:
https://doaj.org/article/fd8cf3f49eba4955a42fb88ddbe0eba1
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 5, Pp 2480-2491 (2022)
Abstract Background Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal muscle wasting, weakness and mitochondrial dysfunction. Peroxisome proliferator‐activated receptor‐gamma coactivator‐1 alpha (PGC1α), a regulator of
Externí odkaz:
https://doaj.org/article/527c4592d80b4722ad3b7a66e827a803
Autor:
Alyson L. Essex, Padmini Deosthale, Joshua R. Huot, Hannah M. Davis, Nicholas Momeni, Andrea Bonetto, Lilian I. Plotkin
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-12 (2022)
Highlights Osteocytic microRNA21 (miR21) removal in OtmiR21Δ mice alters cytokine production and bone mass by modulating osteoclast and osteoblast differentiation and activity. Only female, but not male, OtmiR21Δ mice exhibit higher lean body mass
Externí odkaz:
https://doaj.org/article/32579b5541ce4b178601001da8bd2692
Autor:
Alexander Joseph Jones, Vincent J. Campiti, Mohamedkazim Alwani, Leah J. Novinger, Brady Jay Tucker, Andrea Bonetto, Jessica A. Yesensky, Michael W. Sim, Michael G. Moore, Avinash V. Mantravadi
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 6, Iss 2, Pp 200-210 (2021)
Abstract Objective To determine if sarcopenia is a predictor of blood transfusion requirements in head and neck cancer free flap reconstruction (HNCFFR). Methods A single‐institution, retrospective review was performed of HNCFFR patients with preop
Externí odkaz:
https://doaj.org/article/8ae09aeb0a714923a5e1e7d73c601c36
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cancer cachexia is a debilitating syndrome characterized by skeletal muscle wasting, weakness and fatigue. Several pathogenetic mechanisms can contribute to these muscle derangements. Mitochondrial alterations, altered metabolism and increased oxidat
Externí odkaz:
https://doaj.org/article/7ea3ea982a1043d88734693a732ff4f9
Autor:
Thomas M. O’Connell, Lilian Golzarri-Arroyo, Fabrizio Pin, Rafael Barreto, Stephanie L. Dickinson, Marion E. Couch, Andrea Bonetto
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Background: Cancer cachexia is a severe metabolic disorder characterized by progressive weight loss along with a dramatic loss in skeletal muscle and adipose tissue. Like cancer, cachexia progresses in stages starting with pre-cachexia to cachexia an
Externí odkaz:
https://doaj.org/article/8bc92bbe76294b5b911d317798df2ba7
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 1, Pp 140-154 (2019)
Abstract Background Cancer cachexia is a metabolic disorder involving perturbed energy balance and altered mitochondrial function. Chemotherapy is a primary treatment option for many types of cancer, but there is substantial evidence that some chemot
Externí odkaz:
https://doaj.org/article/db4db5f6b72542b38cf0db3b8f5af6ca
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 1 (2020)
Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured. Animal models for t
Externí odkaz:
https://doaj.org/article/f1d402e87ac242ccb3b66fb330f7b49c
Autor:
Fabrizio Pin, Rafael Barreto, Yukiko Kitase, Sumegha Mitra, Carlie E. Erne, Leah J. Novinger, Teresa A. Zimmers, Marion E. Couch, Lynda F. Bonewald, Andrea Bonetto
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 4, Pp 685-700 (2018)
Abstract Background Cachexia frequently occurs in women with advanced ovarian cancer (OC), along with enhanced inflammation. Despite being responsible for one third of all cancer deaths, cachexia is generally under‐studied in OC due to a limited nu
Externí odkaz:
https://doaj.org/article/ca6a145268b74cdc85ce7324e276fca5