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of 28
pro vyhledávání: '"Andrea Beyerle"'
Autor:
Furong Tian, Adriele Prina-Mello, Giovani Estrada, Andrea Beyerle, Winfried Möller, Holger Schulz, Wolfgang Kreyling, Tobias Stoeger
Publikováno v:
Nano Biomedicine and Engineering, Vol 1, Iss 1, Pp 13-26 (2009)
Several studies have tackled the evaluation of the biocompatibility of nanomaterials in cell and tissue. Nonetheless to date, a quantitative technique for the assessment of the total intracellular nanocarrier dose administered has not been introduced
Externí odkaz:
https://doaj.org/article/a365414bd03549eb8b5049015638feef
Autor:
Andrea Beyerle, Bronwyn A. Kingwell, Samuel D. Wright, Brandon H Greene, Priya Panjwani, Eva Herzog, Barbara Dietrich
Publikováno v:
Toxicology and Applied Pharmacology. 422:115557
CSL112 (apolipoprotein A-I, apo AI [human]) is an investigational drug in Phase 3 development for risk reduction of early recurrent cardiovascular events following an acute myocardial infarction (AMI). Although CSL112 is known to be well tolerated wi
Publikováno v:
Toxicology and Applied Pharmacology. 280:70-77
Fibrinogen, a soluble 340kDa plasma glycoprotein, is critical in achieving and maintaining hemostasis. Reduced fibrinogen levels are associated with an increased risk of bleeding and recent research has investigated the efficacy of fibrinogen concent
Molecular Parameters of siRNA–Cell Penetrating Peptide Nanocomplexes for Efficient Cellular Delivery
Autor:
Petra H. M. Bovee-Geurts, Staffan Lindberg, Andrea Beyerle, Roland Brock, Olaf Heidenreich, Mattias Hällbrink, Hesta McNeill, Alexander Henrik Baron Van Asbeck, Ülo Langel, Wouter P. R. Verdurmen
Publikováno v:
ACS Nano, 7, 5, pp. 3797-807
ACS Nano, 7, 3797-807
ACS Nano, 7, 3797-807
Item does not contain fulltext Cell-penetrating peptides (CPPs) are versatile tools for the intracellular delivery of various biomolecules, including siRNA. Recently, CPPs were introduced that showed greatly enhanced delivery efficiency. However, the
Autor:
Robert Fürst, Bettina A. Mayer, Michael C. Hornburger, Iris Bischoff, Joachim Wegener, Andrea Beyerle
Publikováno v:
Scientific Reports
The most frequently used parameters to describe the barrier properties of endothelial cells (ECs) in vitro are (i) the macromolecular permeability, indicating the flux of a macromolecular tracer across the endothelium and (ii) electrical impedance of
Publikováno v:
Pharmacology Research & Perspectives
Factor XIII (FXIII) is a coagulation protein which plays a major role in hemostasis by covalently cross‐linking fibrin molecules, thereby stabilizing the blood clot and increasing resistance to fibrinolysis. FXIII deficiency, either congenital or a
Autor:
Andrea Beyerle, Oliver Eickelberg, Atrayee Banerjee, Tobias Stoeger, Thomas Kissel, Andrea Braun, Nuran Ercal
Publikováno v:
Biomaterials. 32:8694-8701
Polymeric non-viral vector systems for pulmonary application of siRNA are promising carriers, but have failed to enter clinical trials because of safety and efficiency problems. Therefore, improving their transfection efficiency, as well as their tox
Publikováno v:
Molecular Pharmaceutics. 8:976-981
Genotoxicity information on polymers used for gene delivery is scant, but of great concern, especially when developing polymeric nanocarriers as nonviral vector systems for cancer treatment. The genotoxicity of some engineered nanomaterials, e.g., me
Autor:
Andrea Braun, Andrea Beyerle, Felix P. V. Koch, Thomas Kissel, Tobias Stoeger, Olivia M. Merkel
Publikováno v:
Journal of Controlled Release. 151:51-56
Pulmonary siRNA delivery offers a new way to treat various lung diseases. Poly(ethylene imines) (PEIs) are promising cationic nanocarriers and various modifications are still under investigations to improve their cytotoxicity and efficacy for siRNA d
Publikováno v:
Toxicology and Applied Pharmacology. 242:146-154
Poly(ethylene imine) (PEI) has widely been used as non-viral gene carrier due to its capability to form stable complexes by electrostatic interactions with nucleic acids. To reduce cytotoxicity of PEI, several studies have addressed modified PEIs suc