Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Andrea Bertolotti"'
Autor:
Giacomo Belli, Mateus E. Romão, Riccardo Lacquagni, Barbara Bertoglio, Andrea Bertolotti, Gaia Tamellini, Luca Morini, Gulnaz T. Javan, Ilaria Setti, Silvia D. Visonà
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionThe high rate of incarceration, now exceeding 11.5 million people worldwide, has raised concerns about the conditions within penal institutions, such as the consequences of incarceration on the person. This retrospective study aims to inv
Externí odkaz:
https://doaj.org/article/7644b026a25d480d9f5bc461d40906db
Autor:
Bin Ma, Doug Marcotte, Murugan Paramasivam, Klaus Michelsen, Ti Wang, Andrea Bertolotti-Ciarlet, John Howard Jones, Ben Moree, Margaret Butko, Joshua Salafsky, Xin Sun, Timothy McKee, Laura F Silvian
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165983 (2016)
MLKL is a pore forming pseudokinase involved in the final stage of necroptosis, a form of programmed cell death. Its phosphorylation by RIPK3 is necessary for triggering necroptosis but not for triggering apoptosis, which makes it a unique target for
Externí odkaz:
https://doaj.org/article/67003a59dd434add954b7cdabddde7a6
Autor:
Oscar A Negrete, Mike C Wolf, Hector C Aguilar, Sven Enterlein, Wei Wang, Elke Mühlberger, Stephen V Su, Andrea Bertolotti-Ciarlet, Ramon Flick, Benhur Lee
Publikováno v:
PLoS Pathogens, Vol 2, Iss 2, p e7 (2006)
EphrinB2 was recently discovered as a functional receptor for Nipah virus (NiV), a lethal emerging paramyxovirus. Ephrins constitute a class of homologous ligands for the Eph class of receptor tyrosine kinases and exhibit overlapping expression patte
Externí odkaz:
https://doaj.org/article/1979505c212f47d0a857785230a1e047
Autor:
Dania Rabah, Ti Wang, Jeffery Vessels, Kevin Guckian, Chris Roberts, Andrea Bertolotti-Ciarlet, Norm Alliare, Agnes Gardet, Holly M. Legault, Ramon G. Bonegio, Ian R. Rifkin
Publikováno v:
Poster Presentations.
Background IRAK4 is an important signaling mediator of the innate immune system. IRAK4 initiates MyD88-dependent signaling from most TLRs and from IL-1Rs, resulting in downstream production of pro-inflammatory cytokines1. Objectives Inhibition of IRA
Autor:
Joseph P. Lyssikatos, Douglas Marcotte, Christine Lukacs, Mia Rushe, Kevin Little, Robert M. Arduini, Andrea Bertolotti-Ciarlet, Xin Zhili, Tricia L. May-Dracka, Murugan Paramasivam, Thomas A. Patterson, Govinda Bhisetti, Timothy D. McKee, Kateri Atkins, Michael Cullivan, Thomas Hesson, Laura Silvian, Xin E. Sun
Publikováno v:
Protein Science. 26:152-162
Germinal-center kinase-like kinase (GLK, Map4k3), a GCK-I family kinase, plays multiple roles in regulating apoptosis, amino acid sensing, and immune signaling. We describe here the crystal structure of an activation loop mutant of GLK kinase domain
Autor:
Erik C. Hett, Michelle L. Ols, Kejie Li, Elisabeth Vollman, Tricia L. May-Dracka, Tracy J. Jenkins, Paramasivam Murugan, Weike Zeng, Jun Feng, Kate L. Henry, Capacci Andrew George, Andrea Bertolotti-Ciarlet, Ellen Cahir-McFarland, Brian Lucas, Christine Loh, Alan Buckler, Thomas Cameron, Peter Juhasz, Brian T. Hopkins, Katelin A. Ennis, John E. Anderson, Mercedes Beyna, Benbo Gao, Debra Kellner, Norm Allaire, Govinda Bhisetti, Ru Wei, Bekim Bajrami
Publikováno v:
Science signaling. 11(541)
Members of the family of nuclear factor κB (NF-κB) transcription factors are critical for multiple cellular processes, including regulating innate and adaptive immune responses, cell proliferation, and cell survival. Canonical NF-κB complexes are
Autor:
Linda C. Burkly, Tricia L. May-Dracka, Jason D. Fontenot, Joe Lyssikatos, Timothy D. McKee, Douglas Marcotte, Laura Silvian, Thomas Hesson, Istvan J. Enyedy, Zhili Xin, Thomas A. Patterson, Margot Brickelmaier, Ping Wu, Mia Rushe, Govinda Bhisetti, Robert M. Arduini, Andrea Bertolotti-Ciarlet, Ellen Cahir-McFarland, Paramasivam Murugan, Kerri Spilker, Hairuo Peng, Kevin Little
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(10)
Germinal center kinase-like kinase (GLK, also known as MAP4K3) has been hypothesized to have an effect on key cellular activities, including inflammatory responses. GLK is required for activation of protein kinase C-θ (PKCθ) in T cells. Controlling
Autor:
Joshua Salafsky, Ti Wang, Xin E. Sun, Bin Ma, Klaus Michelsen, Laura Silvian, Timothy D. McKee, Murugan Paramasivam, John Howard Jones, Margaret T. Butko, Andrea Bertolotti-Ciarlet, Douglas Marcotte, Ben Moree
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 11, p e0165983 (2016)
PLoS ONE, Vol 11, Iss 11, p e0165983 (2016)
MLKL is a pore forming pseudokinase involved in the final stage of necroptosis, a form of programmed cell death. Its phosphorylation by RIPK3 is necessary for triggering necroptosis but not for triggering apoptosis, which makes it a unique target for
Publikováno v:
Virology
Rift Valley fever virus (RVFV), a member of the Phlebovirus genus in the Bunyaviridae family, is transmitted by mosquitoes and infects both humans and domestic animals, particularly cattle and sheep. Since primary RVFV strains must be handled in BSL-
Autor:
Michael Wolf, Oscar A. Negrete, Sara T. Hashimi, Claire Marie Filone, Jonathan Fulcher, Linda G. Baum, Luciana Kohatsu, Ian Howard Mchardy, Daniel Y. Choi, Ernest L. Levroney, Benhur Lee, Kenneth A. Matreyek, Andrea Bertolotti-Ciarlet, Hector C. Aguilar, Stephen V. Su
Publikováno v:
Journal of Virology. 80:4878-4889
Nipah virus (NiV) is a deadly emerging paramyxovirus. The NiV attachment (NiV-G) and fusion (NiV-F) envelope glycoproteins mediate both syncytium formation and viral entry. Specific N-glycans on paramyxovirus fusion proteins are generally required fo