Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrea B. Sherk"'
Autor:
Donald P. McDonnell, John D. Norris, Dmitri Kazmin, Scott K. Thompson, Jaclyn R. Patterson, Marlys Hammond, Walter Trizna, Nicholas J. Laping, Jeffrey D. Bray, Christine G. Schnackenberg, Daniel E. Frigo, Andrea B. Sherk
Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth dysregulation observed in prostate cancers. Consequently, androgen ablation has become an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e83eb3282c67e787f8942ba5a7c35a
https://doi.org/10.1158/0008-5472.c.6498402
https://doi.org/10.1158/0008-5472.c.6498402
Autor:
Donald P. McDonnell, John D. Norris, Dmitri Kazmin, Scott K. Thompson, Jaclyn R. Patterson, Marlys Hammond, Walter Trizna, Nicholas J. Laping, Jeffrey D. Bray, Christine G. Schnackenberg, Daniel E. Frigo, Andrea B. Sherk
Supplementary Data from Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd34ad071b42869122db0e920ae8004b
https://doi.org/10.1158/0008-5472.22377012.v1
https://doi.org/10.1158/0008-5472.22377012.v1
Autor:
Cédric Chaveroux, Donald P. McDonnell, Andrea B. Sherk, J. Jasper, John D. Norris, Aymen Shatnawi, Giguère
Publikováno v:
Oncogene. 33:862-871
The androgen receptor (AR) has a critical role in the development and progression of prostate cancer (PC) and is a major therapeutic target in this disease. The transcriptional activity of AR is modulated by the coregulators with which it interacts,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bb6db7c4eb50f984bb27dcb0b9cb15
https://doi.org/10.1038/onc.2013.15
https://doi.org/10.1038/onc.2013.15
Publikováno v:
Cancer Research. 67:9549-9560
One subclass of antiestrogens, the selective estrogen receptor down-regulators (SERDs), have received considerable attention of late as they competitively inhibit estrogen binding and induce a rapid, proteasome-dependent degradation of the receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9faf8524f945a4348bb56392159ded6
https://doi.org/10.1158/0008-5472.can-07-1590
https://doi.org/10.1158/0008-5472.can-07-1590
Autor:
Marlys Hammond, Walter Trizna, Andrea B. Sherk, Donald P. McDonnell, Nicholas J. Laping, Jeffrey D. Bray, Daniel E. Frigo, Dmitri Kazmin, Scott K. Thompson, Christine G. Schnackenberg, John D. Norris, Jaclyn R. Patterson
Publikováno v:
Cancer research. 68(18)
Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth dysregulation observed in prostate cancers. Consequently, androgen ablation has become an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecb1c34b02d745a7f1396419a76c34b
https://pubmed.ncbi.nlm.nih.gov/18794135
https://pubmed.ncbi.nlm.nih.gov/18794135
Autor:
David F. Archer, Cecilia Artacho, Gloria Bachmann, Randall B. Barnes, Kurt T. Barnhart, Yves Muscat Baron, Narender N. Bhatia, Stephanie V. Blank, Mark Brincat, Henry G. Burger, John E. Buster, R. Jeffrey Chang, Ru-fong J. Cheng, Judi L. Chervenak, Claus Christiansen, Thomas B. Clarkson, Felicia Cosman, John P. Curtin, Ivaldo da Silva, Susan R. Davis, Lorraine Dennerstein, Martina Dören, Paul S. Dudley, Richard Eastell, Gregory F. Erickson, David A. Fishman, Ian S. Fraser, Robert R. Freedman, Adriane Fugh-Berman, Ray Galea, J.C. Gallagher, Margery L.S. Gass, Radhika Gogoi, Ellen B. Gold, Juan Gonzalez, Eiran Zev Gorodeski, George I. Gorodeski, Gail A. Greendale, Allison R. Hagey, Georgina E. Hale, Rosemary A. Hannon, Victor W. Henderson, William H. Hindle, Mat H. Ho, Howard N. Hodis, Christian F. Holinka, Diane M. Jacobs, Jay R. Kaplan, Richard H. Karas, Morten A. Karsdal, Harry Irving Katz, Fergus S.J. Keating, Michael Kleerekoper, Kwang Kon Koh, Ronald M. Krauss, Carlo La Vecchia, Sulggi Lee, Seth G. Levrant, Robert Lindsay, Rogerio A. Lobo, Wendy J. Mack, Sten Madsbad, Pauline M. Maki, JoAnn E. Manson, Donald P. McDonnell, C. Noel Bairey Merz, Karin B. Michels, Frederick Naftolin, Morris Notelovitz, James M. Olcese, Annlia Paganini-Hill, C. Leigh Pearce, Alison C. Peck, James H. Pickar, Malcolm C. Pike, Janet Hill Prystowsky, Nancy King Reame, Robert W. Rebar, Catherine A. Roca, Elisheva Rovner, David R. Rubinow, Ichiro Sakuma, Göran Samsioe, Mary Sano, Nanette Santoro, Mark V. Sauer, Peter J. Schmidt, Hermann P.G. Schneider, Andrea B. Sherk, Barbara B. Sherwin, Joe Leigh Simpson, Sven O. Skouby, Leon Speroff, Darcy V. Spicer, Frank Z. Stanczyk, John C. Stevenson, László B. Tankó, Helena J. Teede, Prati Vardhana, Michelle P. Warren, Carolyn Westhoff, Anna H. Wu, Byung-Koo Yoon, Ralf C. Zimmermann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f35abe2cf2655b48f0385c5826491f
https://doi.org/10.1016/b978-012369443-0/50000-4
https://doi.org/10.1016/b978-012369443-0/50000-4
Autor:
Donald P. McDonnell, Andrea B. Sherk
Publisher Summary This chapter provides an update on the mechanisms of action of estrogen and progesterone. Particularly important concepts include nongenomic effects, receptor isoforms that affect agonist/antagonist actions, and the role of coactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ec82af705254424a5300d145b131503
https://doi.org/10.1016/b978-012369443-0/50004-1
https://doi.org/10.1016/b978-012369443-0/50004-1
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 16(3)
ERα is a ligand-activated transcription factor and a key regulator of the processes involved in cellular proliferation and differentiation. In addition, aberrant ERα activity is linked to several pathological conditions including breast cancer. A c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c6304fc1866bcdb311b90545b7d497
https://pubmed.ncbi.nlm.nih.gov/11875103
https://pubmed.ncbi.nlm.nih.gov/11875103
Autor:
Timothy M. Willson, Stephen William Rafferty, James D. Joseph, Delita Arnelle Dye, Erin L. Anderson, Philip Stewart Turnbull, Dmitri Kazmin, Andrea B. Sherk, Daju Fan, Dalia Juzumiene, Xiang Deng, Donald P. McDonnell, Ching-Yi Chang, John D. Norris, Huaxia Cui
Publikováno v:
Chemistry & Biology. (4):452-460
SummaryThe pharmacological activity of different nuclear receptor ligands is reflected by their impact on receptor structure. Thus, we asked whether differential presentation of protein-protein interaction surfaces on the androgen receptor (AR), a su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f02380e0d3b861f0bf25cd6d07c764