Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andrea B Alber"'
Autor:
Daniel Strebinger, Cédric Deluz, Elias T Friman, Subashika Govindan, Andrea B Alber, David M Suter
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 9, Pp 1-19 (2019)
Abstract SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated kn
Externí odkaz:
https://doaj.org/article/c2432b9d74b94e2c9214b92436643553
Autor:
Andrea B. Alber, Hector A. Marquez, Liang Ma, George Kwong, Bibek R. Thapa, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Pushpinder Bawa, Feiya Wang, Yongfeng Luo, Laertis Ikonomou, Wei Shi, Darrell N. Kotton
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract While the generation of many lineages from pluripotent stem cells has resulted in basic discoveries and clinical trials, the derivation of tissue-specific mesenchyme via directed differentiation has markedly lagged. The derivation of lung-sp
Externí odkaz:
https://doaj.org/article/679e27bdb9be4dbfbe24f069fd027cd6
Autor:
Arun Pradhan, Lixiao Che, Vladimir Ustiyan, Abid A. Reza, Nicole M. Pek, Yufang Zhang, Andrea B. Alber, Timothy R. Kalin, Jennifer A. Wambach, Mingxia Gu, Darrell N. Kotton, Matthew E. Siefert, Assem G. Ziady, Tanya V. Kalin, Vladimir V. Kalinichenko
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 207:1042-1054
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) is linked to heterozygous mutations in the FOXF1 gene, a key transcriptional regulator of pulmonary vascular development. There are no effective treatments for ACDMPV other th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84e62a57a4b9ba7085d590bd8aeac1f
https://doi.org/10.1164/rccm.202207-1332oc
https://doi.org/10.1164/rccm.202207-1332oc
Autor:
Andrea B. Alber, Hector A. Marquez, Liang Ma, George Kwong, Bibek R. Thapa, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Pushpinder Bawa, Yongfeng Luo, Laertis Ikonomou, Wei Shi, Darrell N. Kotton
The successful generation of endodermal, ectodermal, and most mesodermal lineages from pluripotent stem cells has resulted in basic discoveries and regenerative medicine clinical trials of cell-based therapies. In contrast, the derivation of tissue-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a494c75076f69d42e279da2ae33afea6
https://doi.org/10.1101/2022.08.12.502651
https://doi.org/10.1101/2022.08.12.502651
Autor:
Andrew A. Wilson, Darrell N. Kotton, Claire L. Burgess, Andrea B. Alber, Kayleigh Berthiaume, Carly Merritt, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Olivia T. Hix, Kristine M. Abo, Jessie Huang, Rhiannon B. Werder
Publikováno v:
Journal of Visualized Experiments.
In the lung, the alveolar epithelium is a physical barrier from environmental stimuli and plays an essential role in homeostasis and disease. Type 2 alveolar epithelial cells (AT2s) are the facultative progenitors of the distal lung epithelium. Dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5d07c5a840b5ce17867d47725fecaa
https://doi.org/10.3791/63875-v
https://doi.org/10.3791/63875-v
Autor:
Alberto Posabella, Andrea B. Alber, Hendrik J. Undeutsch, Raoul A. Droeser, Anthony N. Hollenberg, Laertis Ikonomou, Darrell N. Kotton
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology, Vol 12 (2021)
Stem cell-based therapies to reconstitute in vivo organ function hold great promise for future clinical applications to a variety of diseases. Hypothyroidism resulting from congenital lack of functional thyrocytes, surgical tissue removal, or gland a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85049d54ba054688046660a3bfcc0057
https://doi.org/10.3389/fendo.2021.666565
https://doi.org/10.3389/fendo.2021.666565
Autor:
Andrea B. Alber, David M. Suter
Publikováno v:
Cell cycle (Georgetown, Tex.). 18(8)
Protein expression levels depend on the balance between their synthesis and degradation rates. Even quiescent (G(0)) cells display a continuous turnover of proteins, despite protein levels remaining largely constant over time. In cycling cells, globa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be42e0c1e3ee2f56e6b82543b85178a2
https://pubmed.ncbi.nlm.nih.gov/30907235
https://pubmed.ncbi.nlm.nih.gov/30907235
Autor:
David M. Suter, Andrea B. Alber
Publikováno v:
Journal of Visualized Experiments.
Proteins are in a dynamic state of synthesis and degradation and their half-lives can be adjusted under various circumstances. However, most commonly used approaches to determine protein half-life are either limited to population averages from lysed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db15234f873d6c63cb4215367d3f86b
https://doi.org/10.3791/56604-v
https://doi.org/10.3791/56604-v
Autor:
David M. Suter, Daniel Strebinger, Elias T. Friman, Subashika Govindan, Cédric Deluz, Andrea B. Alber
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 9, Pp n/a-n/a (2019)
Molecular Systems Biology
Molecular Systems Biology
The SOX2 and OCT4 transcription factors are key regulators of embryonic stem (ES) cell self-renewal and differentiation, but how temporal fluctuations in their endogenous expression levels bias lineage commitment is unknown. We generated knock-in rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3cee20ecbaab28a64bd76d51784767
Publikováno v:
Molecular Cell. 71:1079-1091.e9
Cells need to reliably control their proteome composition to maintain homeostasis and regulate growth. How protein synthesis and degradation interplay to control protein expression levels remains unclear. Here, we combined a tandem fluorescent timer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0426fd3ba6b4ded993bb53c32b3636f4
https://doi.org/10.1016/j.molcel.2018.07.023
https://doi.org/10.1016/j.molcel.2018.07.023