Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Andrea Allersdorfer"'
Autor:
Martin Siegemund, Prajakta Oak, Eva-Maria Hansbauer, Andrea Allersdorfer, Karoline Utschick, Alexandra Winter, Christina Grasmüller, Gunther Galler, Jan-Peter Mayer, Benjamin Weiche, Josef Prassler, Roland E. Kontermann, Christine Rothe
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Anticalin® proteins have been proven as versatile clinical stage biotherapeutics. Due to their small size (∼20 kDa), they harbor a short intrinsic plasma half-life which can be extended, e.g., by fusion with IgG or Fc. However, for antagonism of c
Externí odkaz:
https://doaj.org/article/b0e0d1dd68aa479293074992f3f52fe4
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
PDF - 53KB, Demonstration of benign immunogenicity profile of PRS-110 in ex vivo PBMC model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8881e0a9ed9ca395a29f3c3f74ef5f
https://doi.org/10.1158/1535-7163.22497609
https://doi.org/10.1158/1535-7163.22497609
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
Text legends for each supplementary figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794a6d32e65f586163242836d3d88823
https://doi.org/10.1158/1535-7163.22497612.v1
https://doi.org/10.1158/1535-7163.22497612.v1
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
Activation of the MET oncogenic pathway has been implicated in the development of aggressive cancers that are difficult to treat with current chemotherapies. This has led to an increased interest in developing novel therapies that target the MET path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a821aea4ee00d0263cf8b1d610c19bd9
https://doi.org/10.1158/1535-7163.c.6535668.v1
https://doi.org/10.1158/1535-7163.c.6535668.v1
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
PDF - 31KB, Characterisation of cell line panel for MET and HGF expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564d00594a764a618dcb5f852ed7ca37
https://doi.org/10.1158/1535-7163.22497618
https://doi.org/10.1158/1535-7163.22497618
Autor:
Laurent Audoly, Andreas M. Hohlbaum, Kristian Jensen, Stefan Trentmann, Martin Hülsmeyer, Hans Jürgen Christian, Cristina Chiriaco, James F. Burrows, Jakub Jaworski, Bradley M. Lunde, Andrea Allersdorfer, Gabriele Matschiner, Elisa Vigna, Hendrik Gille, Christian Joffroy, Shane A. Olwill
PDF - 136KB, Demonstration of PRS-110 dependent MET trafficking in HT29 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7500d20ba1919fe47d49bea85c5b18a5
https://doi.org/10.1158/1535-7163.22497615.v1
https://doi.org/10.1158/1535-7163.22497615.v1
Autor:
Shane Anthony Olwill, Louis Matis, Christine Rothe, Ulrich Moebius, Julia Schüler, Gabriele Matschiner, Alexander Wiedenmann, Andrea Allersdorfer, Corinna Schlosser, Manuela Carola Dürr, Sven Berger, Thomas J. Jaquin, Rachida Siham Bel Aiba, Marlon J. Hinner
Figure S1: PRS-343 specificity for 4-1BB within TNF receptor superfamily. Seven recombinant human TNF receptor superfamily proteins were purchased from Sino Biological (4-1BB: 10041-H08H, RANK: 16078-H08H, GITR: 13643-H08H, Ox40: 10481-H08H) or R&D S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ec8707cf57011c6e9caa7b6236ec00
https://doi.org/10.1158/1078-0432.22474368
https://doi.org/10.1158/1078-0432.22474368
Autor:
Shane Anthony Olwill, Louis Matis, Christine Rothe, Ulrich Moebius, Julia Schüler, Gabriele Matschiner, Alexander Wiedenmann, Andrea Allersdorfer, Corinna Schlosser, Manuela Carola Dürr, Sven Berger, Thomas J. Jaquin, Rachida Siham Bel Aiba, Marlon J. Hinner
Supplementary Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3495ff05e7ee566eb27ac20741bac6e0
https://doi.org/10.1158/1078-0432.22474365.v1
https://doi.org/10.1158/1078-0432.22474365.v1
Autor:
Shane Anthony Olwill, Louis Matis, Christine Rothe, Ulrich Moebius, Julia Schüler, Gabriele Matschiner, Alexander Wiedenmann, Andrea Allersdorfer, Corinna Schlosser, Manuela Carola Dürr, Sven Berger, Thomas J. Jaquin, Rachida Siham Bel Aiba, Marlon J. Hinner
Purpose:4-1BB (CD137) is a key costimulatory immunoreceptor and promising therapeutic target in cancer. To overcome limitations of current 4-1BB–targeting antibodies, we have developed PRS-343, a 4-1BB/HER2 bispecific molecule. PRS-343 is designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390c0f170adb08f2657eceb656261c87
https://doi.org/10.1158/1078-0432.c.6528768
https://doi.org/10.1158/1078-0432.c.6528768
Autor:
Nicole Andersen, Rachel P. L. van Swelm, Hendrik Gille, Bernd Meibohm, Dorine W. Swinkels, Andrea Allersdorfer, Andreas Hohlbaum, Maria Kolodziejczyk, Laurent P. Audoly, Galina Katzmann, Shane A. Olwill, Hans Jürgen Christian, Barbara Rattenstetter, Stefan Trentmann, Coby M. Laarakkers
Publikováno v:
British Journal of Pharmacology. 175:1054-1065
Background and Purpose Anaemia of chronic disease (ACD) has been linked to iron-restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte-derived peptide that controls systemic iron homeostasis. Here, we rep