The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic

Autor: Carlos S. Casimiro-Soriguer, Javier Pérez-Florido, Enrique A. Robles, María Lara, Andrea Aguado, Manuel A. Rodríguez Iglesias, José A. Lepe, Federico García, Mónica Pérez-Alegre, Eloísa Andújar, Victoria E. Jiménez, Lola P. Camino, Nicola Loruso, Ulises Ameyugo, Isabel María Vazquez, Carlota M. Lozano, J. Alberto Chaves, Joaquin Dopazo

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract The One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of

Externí odkaz: https://doaj.org/article/2a5df0cdf4eb47e8aa9e9001dea781ea

Toll-like receptor 4 upregulation by angiotensin II contributes to hypertension and vascular dysfunction through reactive oxygen species production.

Autor: Priscila R De Batista, Roberto Palacios, Angela Martín, Raquel Hernanz, Cindy T Médici, Marito A S C Silva, Emilly M Rossi, Andrea Aguado, Dalton V Vassallo, Mercedes Salaices, María J Alonso

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104020 (2014)

Hypertension is considered as a low-grade inflammatory disease, with adaptive immunity being an important mediator of this pathology. TLR4 may have a role in the development of several cardiovascular diseases; however, little is known about its parti

Externí odkaz: https://doaj.org/article/0f1d2946902941078be6d6cc3b437cfd

Pioglitazone modulates the vascular contractility in hypertension by interference with ET-1 pathway

Autor: Ana M. Briones, Andrea Aguado, Zoe González-Carnicero, Mercedes Salaices, M. T. Barrús, María J. Alonso, Frederic Jaisser, Angela Martín, Raquel Hernanz, Roberto Palacios‐Ramirez, Jose V. Pérez-Girón

Publikováno v: Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.16461. ⟨10.1038/s41598-019-52839-6⟩
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)

Endothelin-1 (ET-1) is an important modulator of the vascular tone and a proinflammatory molecule that contributes to the vascular damage observed in hypertension. Peroxisome-proliferator activated receptors-γ (PPARγ) agonists show cardioprotective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b3a7be2ac05de0ba95e5ddb3e8c726
http://hdl.handle.net/10486/691928

Role of COX-2-derived PGE2on vascular stiffness and function in hypertension

Autor: Mercedes Salaices, Dalton Valentim Vassallo, Luis Vila, J García-Puig, Roberto Palacios, María González-Amor, M V Cachofeiro, Ana M. Briones, María J. Alonso, Maylla Ronacher Simões, Luis M. Beltrán, María S. Avendaño, Sonia Martínez-Revelles, P Guillem-Llobat, Andrea Aguado

Publikováno v: British Journal of Pharmacology. 173:1541-1555

Background and purpose Prostanoids derived from COX-2 and EP receptors are involved in vascular remodelling in different cardiovascular pathologies. This study evaluates the contribution of COX-2 and EP1 receptors to vascular remodelling and function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91a18042dd5ab345e68a953d18da86d1
https://doi.org/10.1111/bph.13457

mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress

Autor: Mercedes Camacho, María S. Avendaño, María González-Amor, Sonia Martínez-Revelles, Andrea Aguado, Mercedes Salaices, María J. Alonso, Ana B. García-Redondo, Luis M. Beltrán, Ana M. Briones, Guillermo Zalba, Victoria Cachofeiro

Publikováno v: HYPERTENSION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

mPGES-1 (microsomal prostaglandin E synthase-1), the downstream enzyme responsible for PGE 2 (prostaglandin E 2 ) synthesis in inflammatory conditions and oxidative stress are increased in vessels from hypertensive animals. We evaluated the role of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07afe377c3c62e23079fe31fedf2521
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3729