Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Andrea Ablasser"'
Autor:
Melania Balzarolo, Sander Engels, Anja J. de Jong, Katka Franke, Timo K. van den Berg, Muhammet F. Gulen, Andrea Ablasser, Edith M. Janssen, Bas van Steensel, Monika C. Wolkers
Publikováno v:
Open Biology, Vol 11, Iss 3 (2021)
Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N6 position of adenines (m6A), a modification that is rare in mammalian host DNA.
Externí odkaz:
https://doaj.org/article/7352304321c146c295f01e205c0dafa9
Autor:
Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The cGAS/STING signalling pathway is responsible for sensing intracellular DNA and activating downstream inflammatory genes. Here the authors show mouse primary T cells and T leukaemia are hyperresponsive to STING agonist, and this strong STING signa
Externí odkaz:
https://doaj.org/article/dd0445dd4e334afc9d468d8ec62cb61e
Autor:
Natasha Samson, Andrea Ablasser
Publikováno v:
Nature Cancer. 3:1452-1463
Autor:
Ying Liu, Pengbiao Xu, Sophie Rivara, Chong Liu, Jonathan Ricci, Xuefeng Ren, James H. Hurley, Andrea Ablasser
Publikováno v:
Nature. 610:761-767
Stimulator of interferon genes (STING) functions downstream of cyclic GMP-AMP synthase in DNA sensing or as a direct receptor for bacterial cyclic dinucleotides and small molecules to activate immunity during infection, cancer and immunotherapy1–10
Autor:
Marilena Wischnewski, Andrea Ablasser
Publikováno v:
Elsevier
Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in
Autor:
Mark Schmitt, Fatih Ceteci, Jalaj Gupta, Marina Pesic, Tim W. Böttger, Adele M. Nicolas, Kilian B. Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisözü, Valentina Petrocelli, Yasamin Dabiri, Julia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C. Arkan, Frederic J. de Sauvage, Florian R. Greten
Publikováno v:
Nature
Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth(1,2). Increasing evidence links enhanced cancer cell apoptosis to paracrine activation of cells in the tumour microenvironm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a15b5f6102e61823c51a5240859270f
https://europepmc.org/articles/PMC7613947/
https://europepmc.org/articles/PMC7613947/
Autor:
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M.C. Böhner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A.I. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Rösen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
Publikováno v:
Journal of Experimental Medicine. 219
Publikováno v:
Nature Reviews. Immunology
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS–STING pathway is its capacity to sense and regulate the
Autor:
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina Maria Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M.C. Böhner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A. I. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Rösen-Wolff, Lino Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
Autoimmune vasculitis is a group of life-threatening diseases, whose underlying pathogenic mechanisms are incompletely understood, hampering development of targeted therapies. Here, we demonstrate that patients suffering from anti-neutrophil cytoplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efdf94db961de71e7e1893d5391057b2
https://doi.org/10.1101/2022.05.30.493983
https://doi.org/10.1101/2022.05.30.493983
Autor:
Sun Hur, Andrea Ablasser
Publikováno v:
Nature Immunology. 21:17-29
Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the