Zobrazeno 1 - 10
of 543
pro vyhledávání: '"Andrea Vasella"'
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 25 (2022)
The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosome
Externí odkaz:
https://doaj.org/article/69ec20fa2d5a4d578e57d6c384c9c84c
Autor:
Michael G. Pirrone, Chennaiah Ande, Klara Haldimann, Sven N. Hobbie, Andrea Vasella, Erik C. Böttger, David Crich
Publikováno v:
ChemMedChem. 18
An intramolecular hydrogen bond between the protonated equatorial 7'-methylamino group of apramycin and the vicinal axial 6'-hydroxy group acidifies the 6'-hydroxy group leading to a strong hydrogen bond to A1408 in the ribosomal drug binding pocket
Autor:
Rukshana Mohamad-Ramshan, Chennaiah Ande, Takahiko Matsushita, Klara Haldimann, Andrea Vasella, Sven N. Hobbie, David Crich
Publikováno v:
Tetrahedron. 135:133330
Publikováno v:
RSC Med Chem
In order to further investigate the importance of the conformation of the ring I side chain in aminoglycoside antibiotic binding to the ribosomal target several derivatives of paromomycin were designed with conformationally locked side chains. By cha
Publikováno v:
Molecules, Vol 18, Iss 4, Pp 3906-3916 (2013)
The synthesis of stable guanofosfocin analogues has attracted considerable attention in the past 15 years. Several guanofosfocin analogues mimicking the three constitutional elements of mannose, ribose, and guanine were designed and synthesized. Inte
Externí odkaz:
https://doaj.org/article/0003f8e7fec8417fb7d165da8c45c5ed
Publikováno v:
J Org Chem
To facilitate the synthesis of paromomycin and/or neomycin analogues, we describe a cleavage of ring I from paromomycin that proceeds in the presence of azides and affords a glycosyl acceptor for the installation of a modified ring I. A paromomycin 4
Autor:
Vikram A. Sarpe, Klara Haldimann, Jonathan C. K. Quirke, Parasuraman Rajasekaran, David Crich, Erik C. Böttger, Andrea Vasella, Marina Gysin, Dimitri Shcherbakov, Ivan Osinnii, Qiao-Jun Fang, Su-Hua Sha, Amr Sonousi, Jochen Schacht, Sven N. Hobbie
Publikováno v:
J Am Chem Soc
Apramycin is a structurally unique member of the 2-deoxystreptamine class of aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that carries an unusual bicyclic eight-carbon dialdose moiety. Because of its unusual s
Autor:
Takahiko Matsushita, Sven N. Hobbie, Lubriks Dimitrijs, Edgars Suna, Klara Haldimann, David Crich, Marina Gysin, Erik C. Böttger, Andrea Vasella, Vikram A. Sarpe, Girish C. Sati, Rimants Zogota
Publikováno v:
ACS Infect Dis
Propylamycin (4'-deoxy-4'-propylparomomycin) is a next generation aminoglycoside antibiotic that displays increased antibacterial potency over the parent, coupled with reduced susceptibility to resistance determinants and reduced ototoxicity in the g
Autor:
Takahiko Matsushita, Girish C. Sati, Nuwan Kondasinghe, Michael G. Pirrone, Takayuki Kato, Prabuddha Waduge, Harshitha Santhosh Kumar, Adrian Cortes Sanchon, Malgorzata Dobosz-Bartoszek, Dimitri Shcherbakov, Mario Juhas, Sven N. Hobbie, Thomas Schrepfer, Christine S. Chow, Yury S. Polikanov, Jochen Schacht, Andrea Vasella, Erik C. Böttger, David Crich
Publikováno v:
Journal of the American Chemical Society. 141:5051-5061
Infectious diseases due to multidrug-resistant pathogens, particularly carbapenem-resistant Enterobacteriaceae (CREs), present a major and growing threat to human health and society, providing an urgent need for the development of improved potent ant
Publikováno v:
MedChemComm. 10:946-950
Halogenation of a suitably protected netilmicin derivative enables preparation of 4′-chloro-, bromo-, and iodo derivatives of netilmicin after deprotection. Suzuki coupling of a protected 4′-bromo derivative with phenylboronic acid or butyltriflu