Roadmap for the use of base editors to decipher drug mechanism of action.

Autor: Estel Aparicio-Prat, Dong Yan, Marco Mariotti, Michael Bassik, Gaelen Hess, Jean-Philippe Fortin, Andrea Weston, Hualin S Xi, Robert Stanton

Publikováno v: PLoS ONE, Vol 16, Iss 9, p e0257537 (2021)

CRISPR base editors are powerful tools for large-scale mutagenesis studies. This kind of approach can elucidate the mechanism of action of compounds, a key process in drug discovery. Here, we explore the utility of base editors in an early drug disco

Externí odkaz: https://doaj.org/article/7653c551366442d8a8e4bbbeede6a9dd

Generation of a clonal induced pluripotent stem cell (iPSC) line expressing the mutant MECP2 allele from a Rett Syndrome patient fibroblast line

Autor: Lisa Hunihan, Jeffrey Brown, Angela Cacace, Alda Fernandes, Andrea Weston

Publikováno v: Stem Cell Research, Vol 20, Iss C, Pp 67-69 (2017)

Human fibroblast cells collected from a 3-year old, female Rett Syndrome patient with a 32 bp deletion in the X-linked MECP2 gene were obtained from the Coriell Institute. Fibroblasts were reprogrammed to iPSC cells using a Sendai-virus delivery syst

Externí odkaz: https://doaj.org/article/6b8ba478250e41d0b3d3429c4e8e74b9

Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4):an unmasked randomised controlled trial

Autor: Richard J McManus, Jonathan Mant, Marloes Franssen, Alecia Nickless, Claire Schwartz, James Hodgkinson, Peter Bradburn, Andrew Farmer, Sabrina Grant, Sheila M Greenfield, Carl Heneghan, Susan Jowett, Una Martin, Siobhan Milner, Mark Monahan, Sam Mort, Emma Ogburn, Rafael Perera-Salazar, Syed Ahmar Shah, Ly-Mee Yu, Lionel Tarassenko, F D Richard Hobbs, Brendan Bradley, Chris Lovekin, David Judge, Luis Castello, Maureen Dawson, Rebecca Brice, Bethany Dunbabin, Sophie Maslen, Heather Rutter, Mary Norris, Lauren French, Michael Loynd, Pippa Whitbread, Luisa Saldana Ortaga, Irene Noel, Karen Madronal, Julie Timmins, Lucy Hughes, Beth Hinks, Sheila Bailey, Sue Read, Andrea Weston, Somi Spannuth, Sue Maiden, Makiko Chermahini, Ann McDonald, Shelina Rajan, Sue Allen, Brenda Deboys, Kim Fell, Jenny Johnson, Helen Jung, Rachel Lister, Ruth Osborne, Amy Secker, Irene Qasim, Kirsty William, Abi Harris, Susan Zhao, Elaine Butcher, Pauline Darbyshire, Sarah Joshi, Jon Davies, Claire Talbot, Eleanor Hoverd, Linda Field, Tracey Adcock, Julia Rooney, Nina Cooter, Aaron Butler, Naomi Allen, Maria Abdul-Wahab, Kathryn McNicholas, Lara Peniket, Kate Dodd, Julie Mugurza, Richard Baskerville, Rakshan Syed, Clare Bailey, Jill Adams, Paul Uglow, Neil Townsend, Alison Macleod, Charlotte Hawkins, Suparna Behura, Jonathan Crawshaw, Robin Fox, Waleed Doski, Martin Aylward, Christine A'Court, David Rapley, Jo Walsh, Paul Batra, Ana Seoane, Sluti Mukherjee, Jonathan Dixon, Peter Arthur, Karen Sutcliffe, Costas Paschallides, Richard Woof, Peter Winfrey, Matthew Clark, Roya Kamali, Paul Thomas, David Ebbs, Liz Mather, Andre Beattie, Karim Ladha, Larisa Smondulak, Surinder Jemahl, Peter Hickson, Liam Stevens, Tony Crockett, David Shukla, Ian Binnian, Paul Vinson, Nigel DeKare-Silver, Ramila Patel, Ivor Singh, Louise Lumley, Glennis Williams, Mark Webb, Jack Bambrough, Neetul Shah, Hergeven Dosanjh, Frank Spannuth, Carolyn Paul, Jude Ganesegaram, Laurie Pike, Vijaysundari Maheswaran, Farah Paruk, Stephen Ford, Vineeta Verma, Kate Milne, Farhana Lockhat, Jennifer Ferguson, Anne-Marie Quirk, Hugo Wilson, David Copping, Sam Bajallan, Simria Tanvir, Faheem Khan, Tom Alderson, Amar Ali, Richard Young, Umesh Chauhan, Lindsey Crockett, Louise McGovern, Claire Cubitt, Simon Weatherill, Abdul Tabassum, Philip Saunders, Naresh Chauhan, Samantha Johnson, Inderjit Marok, Rajiv Sharma, William Lumb, John Tweedale, Ian Smith, Lawrence Miller, Tanveer Ahmed, Mark Sanderson, Claire Jones, Peter Stokell, Matthew J Edwards, Andrew Askey, Jason Spencer, Kathryn Morgan, Kyle Knox, Robert Baker, Crispin Fisher, Rachel Halstead, Neil Modha, David Buckley, Catherine Stokell, John Gerald McCabe, Jennifer Taylor, Helen Nutbeam, Richard Smith, Christopher MacGregor, Sam Davies, Mark Lindsey, Simon Cartwright, Jonathan Whittle, Julie Colclough, Alison Crumbie, Nicholas Thomas, Vattakkatt Premchand, Rafia Hamid, Zishan Ali, John Ward, Philip Pinney, Stephen Thurston, Tina Banerjee

Publikováno v: McManus, R, Mant, J, Franssen, M, Nickless, A, Schwartz, C, Hodgkinson, J A, Bradburn, P, Grant, S, Farmer, A, Greenfield, S, Heneghan, C, Jowett, S, Martin, U, Milner, S L, Monahan, M, Mort, S, Ogburn, E, Perera-Salazar, R, Shah, S, Yu, L-M, Tarassenko, L, Hobbs, F D R 2018, ' Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4) : an unmasked randomised controlled trial ', Lancet, vol. 391, no. 10124, pp. 949-959 . https://doi.org/10.1016/S0140-6736(18)30309-X
Lancet (London, England)
McManus, R J, Mant, J, Franssen, M, Nickless, A, Schwartz, C, Hodgkinson, J, Bradburn, P, Farmer, A, Grant, S, Greenfield, S M, Heneghan, C, Jowett, S, Martin, U, Milner, S, Monahan, M, Mort, S, Ogburn, E, Perera-Salazar, R, Shah, S A, Yu, L-M & Tarassenko, L & Hobbs, F D R 2018, ' Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial ', The Lancet, vol. 391, no. 10124, pp. 949-959 . https://doi.org/10.1016/S0140-6736(18)30309-X

BACKGROUND: Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place of telemonitoring over self-monitoring alone is unclear. The TASMINH4 trial aimed to assess the efficacy o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b898623766880e2558662bb61e2c8be
https://research-information.bris.ac.uk/ws/files/150873850/PIIS0140_6736_18_30309_X.pdf

Potentially Inappropriate Medication Use in Older Adults With Mild Cognitive Impairment

Autor: Kristine Yaffe, Cynthia Barton, Andrea Weston, Andrea M. Weinstein

Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :318-321

Background. Patients with mild cognitive impairment (MCI) may be especially vulnerable to the side effects of potentially inappropriate medications (PIMs), especially those that impair cognition. Methods. We conducted a cross-sectional study to deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599733c1ee58dfbe8916414fe1bf26a9
https://doi.org/10.1093/gerona/glp158

P3‐193: The plasma Aβ42/Aβ40 ratio: A promising biomarker for cognitive decline

Autor: Eleanor M. Simonsick, Linda H. Younkin, Neill R. Graff-Radford, Jingzhong Dong, Tamara B. Harris, Suzanne Satterfield, Hilsa N. Ayonayon, Nanjiang Hou, Andrea Weston, Lewis H. Kuller, Kristine Yaffe, Steven G. Younkin

Publikováno v: Alzheimer's & Dementia. 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f27cf90650a7306d41408d0a186117a
https://doi.org/10.1016/j.jalz.2010.05.1691