Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Andrea, Vaclavkova"'
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Long-term Treatment With Ponesimod in Relapsing-Remitting Multiple Sclerosis
Autor: Mark S, Freedman, Carlo, Pozzilli, Eva Kubala, Havrdova, Alexandre, Lemle, Michel, Burcklen, Anna, Larbalestier, Brian, Hennessy, Tatiana, Sidorenko, Andrea, Vaclavkova, Tomas, Olsson
Publikováno v: Neurology. 99:e762-e774
ObjectiveTo evaluate the dose-response relationship of 10, 20, and 40 mg ponesimod and long-term efficacy and safety of ponesimod 20 mg using an analysis of combined data from the phase 2 Core and Extension studies in patients with relapsing-remittin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4ac00dbb03653b5ac76c9cf9253087
https://doi.org/10.1212/wnl.0000000000200606
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3
Mitigation of Initial Cardiodynamic Effects of the S1P1Receptor Modulator Ponesimod Using a Novel Up-Titration Regimen
Autor: Jasper Dingemanse, Jim Bush, Matthias Hoch, Andrea Vaclavkova, Andreas Krause, Pierre-Eric Juif
Publikováno v: The Journal of Clinical Pharmacology. 57:401-410
Ponesimod, a potent selective sphingosine-1-phosphate receptor 1 modulator, leads to a reduction in circulating total lymphocyte count and transient decreases in heart rate (HR). Based on a modeling and simulation approach, this study was conducted t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d8407f3ab3dfa922434fff30c7a9aeb
https://doi.org/10.1002/jcph.820
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4
Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P1 Receptor Modulator in Healthy Subjects
Autor: Darren Wilbraham, Daniela Baldoni, Maribel Reyes, Pierre-Eric Juif, Andrea Vaclavkova, Jasper Dingemanse, Matthias Hoch, Salvatore Febbraro
Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 12, p 2636 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2636
The pharmacokinetics, pharmacodynamics, tolerability, and food effect of cenerimod, a potent sphingosine-1-phosphate subtype 1 receptor modulator, were investigated in three sub-studies. Two double-blind, placebo-controlled, randomised studies in hea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c4f4eb091bcb561bf0119f4cd4dd0f
https://www.mdpi.com/1422-0067/18/12/2636
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5
Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P₁ Receptor Modulator in Healthy Subjects
Autor: Pierre-Eric, Juif, Daniela, Baldoni, Maribel, Reyes, Darren, Wilbraham, Salvatore, Febbraro, Andrea, Vaclavkova, Matthias, Hoch, Jasper, Dingemanse
Publikováno v: International Journal of Molecular Sciences
The pharmacokinetics, pharmacodynamics, tolerability, and food effect of cenerimod, a potent sphingosine-1-phosphate subtype 1 receptor modulator, were investigated in three sub-studies. Two double-blind, placebo-controlled, randomised studies in hea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e32702bd0d13a8884dc2e7026d52965
https://pubmed.ncbi.nlm.nih.gov/29211013
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6
Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-controlled phase 2 trial
Autor: Andrea Vaclavkova, Paul-Gunther Sator, Péter Holló, Daniele D'Ambrosio, Sergio Chimenti, Petr Arenberger, Mylene Stefani, Michel Burcklen
Publikováno v: The Lancet. 384:2036-2045
We assessed the efficacy, safety, and tolerability of ponesimod, an oral, selective, reversible modulator of sphingosine 1-phosphate receptor 1, in patients with moderate to severe chronic plaque psoriasis.Between Sept 22, 2010, and Oct 24, 2012, pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121d38c67e2504ec6042cfae43bebbbf
https://doi.org/10.1016/s0140-6736(14)60803-5
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