Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrea, Pegoli"'
Autor:
Xueke She, Andrea Pegoli, Judith Mayr, Harald Hübner, Günther Bernhardt, Peter Gmeiner, Max Keller
Publikováno v:
ACS Omega, Vol 2, Iss 10, Pp 6741-6754 (2017)
Externí odkaz:
https://doaj.org/article/ccc71977ac8542fabfefb2480ed6e0de
Autor:
Mengya Chen, Nicholas D. Holliday, Jianfei Wan, Günther Bernhardt, Max Keller, Corinna G. Gruber, Xueke She, Andrea Pegoli, Harald Hübner, Peter Gmeiner, Jessica Carpenter, David Wifling
Publikováno v:
Journal of Medicinal Chemistry. 63:4133-4154
Fluorescently labeled dibenzodiazepinone-type muscarinic acetylcholine receptor (MR) antagonists, including dimeric ligands, were prepared using red-emitting cyanine dyes. Probes containing a fluorophore with negative charge showed high M2R affinitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e95ec7277d054214aa57332c1016c5
https://doi.org/10.1021/acs.jmedchem.9b02172
https://doi.org/10.1021/acs.jmedchem.9b02172
Publikováno v:
RSC Med Chem
A series of fluorescent dibenzodiazepinone-type muscarinic acetylcholine M(2) receptor (M(2)R) ligands was synthesized using various fluorescent dyes (5-TAMRA, λ(ex)/λ(em) ≈ 547/576 nm; BODIPY 630/650, λ(ex)/λ(em) ≈ 625/640 nm; pyridinium dye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b21b6e2aee62a40aea804393e74bb26
https://doi.org/10.1039/d0md00137f
https://doi.org/10.1039/d0md00137f
Autor:
Lisa Schindler, Nicholas D. Holliday, Andrea Pegoli, Max Keller, Jessica Carpenter, Vivyanne Hong Yee, Peter Gmeiner, Günther Bernhardt, Shahani A. Mahuroof, Timo Littmann, Harald Hübner
Publikováno v:
ACS Medicinal Chemistry Letters
Fluorescence-labeled receptor ligands have emerged as valuable molecular tools, being indispensable for studying receptor–ligand interactions by fluorescence-based techniques such as high-content imaging, fluorescence microscopy, and fluorescence p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad3554e425574ec5d9bc7e932ae3d61
https://doi.org/10.1021/acsmedchemlett.9b00462
https://doi.org/10.1021/acsmedchemlett.9b00462
Autor:
Andrea Pegoli, Corinna G. Gruber, Xueke She, Max Keller, David Wifling, Günther Bernhardt, Harald Hübner, Peter Gmeiner
Publikováno v:
Journal of Medicinal Chemistry. 62:5358-5369
Muscarinic acetylcholine receptors (MRs), comprising five subtypes (M1R–M5R) in humans, exhibit a high degree of structural similarity. Therefore, subtype-selective MR agonists and antagonists are ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b0e3d7acde8d93713bbb37a157c151
https://doi.org/10.1021/acs.jmedchem.8b01967
https://doi.org/10.1021/acs.jmedchem.8b01967
Autor:
Lukas, Grätz, Tõnis, Laasfeld, Anni, Allikalt, Corinna G, Gruber, Andrea, Pegoli, Maris-Johanna, Tahk, Mari-Liis, Tsernant, Max, Keller, Ago, Rinken
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1868(3)
BRET and fluorescence anisotropy (FA) are two fluorescence-based techniques used for the characterization of ligand binding to G protein-coupled receptors (GPCRs) and both allow monitoring of ligand binding in real time. In this study, we present the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a0824993309d9c4e35251a8cf2eed84
https://pubmed.ncbi.nlm.nih.gov/33347921
https://pubmed.ncbi.nlm.nih.gov/33347921
Autor:
David Wifling, Harald Hübner, Andrea Pegoli, Max Keller, Peter Gmeiner, Xueke She, Günther Bernhardt
Publikováno v:
Journal of Medicinal Chemistry. 60:3314-3334
The dualsteric ligand approach, aiming at ligands with improved subtype selectivity, has been increasingly applied to muscarinic receptors (MRs). In this article, we present the synthesis and characterization of a M2R subtype-preferring radiolabeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74610259982adb9b188db2ea7ff09702
https://doi.org/10.1021/acs.jmedchem.6b01892
https://doi.org/10.1021/acs.jmedchem.6b01892
Autor:
Maris-Johanna Tahk, Max Keller, Corinna G. Gruber, Andrea Pegoli, Tõnis Laasfeld, Mari-Liis Tsernant, Lukas Grätz, Ago Rinken, Anni Allikalt
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1868:118930
BRET and fluorescence anisotropy (FA) are two fluorescence-based techniques used for the characterization of ligand binding to G protein-coupled receptors (GPCRs) and both allow monitoring of ligand binding in real time. In this study, we present the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79810659141043e24c464215cea4c34d
https://doi.org/10.1016/j.bbamcr.2020.118930
https://doi.org/10.1016/j.bbamcr.2020.118930
Autor:
Andrea, Pegoli, Xueke, She, David, Wifling, Harald, Hübner, Günther, Bernhardt, Peter, Gmeiner, Max, Keller
Publikováno v:
Journal of medicinal chemistry. 60(8)
The dualsteric ligand approach, aiming at ligands with improved subtype selectivity, has been increasingly applied to muscarinic receptors (MRs). In this article, we present the synthesis and characterization of a M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a9e8df8212e31a3e9ed9cf06495702d
https://pubmed.ncbi.nlm.nih.gov/28388054
https://pubmed.ncbi.nlm.nih.gov/28388054
Autor:
Günther Bernhardt, Christian Tränkle, Armin Buschauer, Andrea Pegoli, Xueke She, Max Keller, Roger W. Read
Publikováno v:
Bioorganicmedicinal chemistry. 23(14)
A series of new dibenzodiazepinone-type muscarinic receptor ligands, including two homo-dimeric compounds, was prepared. Sixteen representative compounds were characterized in equilibrium binding studies with [3H]N-methylscopolamine ([3H]NMS) at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9e0eaed06540400d76e44b89ace76c
https://pubmed.ncbi.nlm.nih.gov/25650309
https://pubmed.ncbi.nlm.nih.gov/25650309