Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Andrea, Newbold"'
Autor:
Danielle H. Oh, Xiao MA, Jackson He, Conor Kearney, Simon J. Hogg, Andrea Newbold, Peter Fraser, Ian G. Jennings, Daniella Brasacchio, Olivia Susanto, Chun Yew Fong, Mark A. Dawson, Emily Gruber, Lev Kats, Ricky W. Johnstone, Philip E. Thompson, Jake Shortt
Publikováno v:
HemaSphere, Vol 7, p e4369469 (2023)
Externí odkaz:
https://doaj.org/article/93d888a242994fae978e83427bf5bb01
Autor:
Lin Xiao, Mawar Karsa, Emma Ronca, Angelika Bongers, Angelika Kosciolek, Ali El-Ayoubi, Jezrael L. Revalde, Janith A. Seneviratne, Belamy B. Cheung, Laurence C. Cheung, Rishi S. Kotecha, Andrea Newbold, Stefan Bjelosevic, Greg M. Arndt, Richard B. Lock, Ricky W. Johnstone, Andrei V. Gudkov, Katerina V. Gurova, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Klaartje Somers
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome. Driven by the unmet need to develop better therapies for KMT2A-rearranged leuke
Externí odkaz:
https://doaj.org/article/030ef39db2a746f68cb7bcf2cf823422
Autor:
Ricky W. Johnstone, Jake Shortt, James E. Bradner, Richard W. Tothill, Eva Vidacs, Marcus Lefebure, Gareth P. Gregory, Benjamin P. Martin, Leonie A. Cluse, Stephin J. Vervoort, Andrea Newbold, Simon J. Hogg
Supplementary Methods, Supplementary References, Supplementary Figure 1 - in vitro analysis of various BET inhibitors against Eu-myc lymphoma cells and effect of JQ1 on OPM2 and OPM2/BCL2 cells; Supplementary Figure 2 - In vitro effects of JQ1 on OPM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f49e7f8c3429f7637a2c30ba614957
https://doi.org/10.1158/1535-7163.22503375
https://doi.org/10.1158/1535-7163.22503375
Autor:
Ricky W. Johnstone, Saverio Minucci, J. Paul Secrist, Victoria M. Richon, Joey L. Methot, Thomas A. Miller, Nicole D. Ozerova, Astrid M. Kral, Susanna Chiocca, Claudia Miccolo, Ross A. Dickins, Ailsa J. Christiansen, Jessica E. Bolden, Carleen Cullinane, Kellie-Marie Banks, Christopher J.P. Clarke, Leonie A. Cluse, Michael Bots, Geoffrey M. Matthews, Andrea Newbold
PDF file - 1496K, Supplementary Methods; Supplementary Figure 1: Production and characterisation of tumor cells dependent on Bcr-Abl for survival; Supplementary Figure 2: HDACi with different isoform specificities induce apoptosis of Bcr-Abl(p210) ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51845ee47377f86143df810793c178b8
https://doi.org/10.1158/1535-7163.22498807.v1
https://doi.org/10.1158/1535-7163.22498807.v1
Autor:
Ricky W. Johnstone, Saverio Minucci, J. Paul Secrist, Victoria M. Richon, Joey L. Methot, Thomas A. Miller, Nicole D. Ozerova, Astrid M. Kral, Susanna Chiocca, Claudia Miccolo, Ross A. Dickins, Ailsa J. Christiansen, Jessica E. Bolden, Carleen Cullinane, Kellie-Marie Banks, Christopher J.P. Clarke, Leonie A. Cluse, Michael Bots, Geoffrey M. Matthews, Andrea Newbold
Histone deacetylase inhibitors (HDACi) are anticancer agents that induce hyperacetylation of histones, resulting in chromatin remodeling and transcriptional changes. In addition, nonhistone proteins, such as the chaperone protein Hsp90, are functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367cd916bfc9f81672a5130168011dac
https://doi.org/10.1158/1535-7163.c.6535972.v1
https://doi.org/10.1158/1535-7163.c.6535972.v1
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
Figure S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444106ead769434517a6030981d594b4
https://doi.org/10.1158/1078-0432.22476393.v1
https://doi.org/10.1158/1078-0432.22476393.v1
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
contains methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f66d7cdc5a26035ed01be67bc7dad53
https://doi.org/10.1158/1078-0432.22476381.v1
https://doi.org/10.1158/1078-0432.22476381.v1
Autor:
Ricky W. Johnstone, Anthony E. Dear, Kate F. Whitecross, Leonie A. Cluse, Ralph K. Lindemann, Andrea Newbold
Supplementary Table S1 from Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3081173963c601ea8d75e88a7769667f
https://doi.org/10.1158/1535-7163.22485884
https://doi.org/10.1158/1535-7163.22485884
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
Purpose:Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2–selective inhibitor, has had success in the clinic, another family member, Bcl-xL, has also em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8844690ddeffa8863fd595c34c80f01
https://doi.org/10.1158/1078-0432.c.6529392
https://doi.org/10.1158/1078-0432.c.6529392
Autor:
Ricky W. Johnstone, Anthony E. Dear, Kate F. Whitecross, Leonie A. Cluse, Ralph K. Lindemann, Andrea Newbold
Histone deacetylase inhibitors (HDACi) are compounds that target the epigenome and cause tumor cell-selective apoptosis. A large number of these agents that have different chemical structures and can target multiple HDACs are being testing in clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80d149e18df6bf95d4c9280d85330a4
https://doi.org/10.1158/1535-7163.c.6532124.v1
https://doi.org/10.1158/1535-7163.c.6532124.v1