Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andrea, Gunnell"'
Autor:
Molly Went, Laura Duran-Lozano, Gisli H. Halldorsson, Andrea Gunnell, Nerea Ugidos-Damboriena, Philip Law, Ludvig Ekdahl, Amit Sud, Gudmar Thorleifsson, Malte Thodberg, Thorunn Olafsdottir, Antton Lamarca-Arrizabalaga, Caterina Cafaro, Abhishek Niroula, Ram Ajore, Aitzkoa Lopez de Lapuente Portilla, Zain Ali, Maroulio Pertesi, Hartmut Goldschmidt, Lilja Stefansdottir, Sigurdur Y. Kristinsson, Simon N. Stacey, Thorvardur J. Love, Saemundur Rognvaldsson, Roman Hajek, Pavel Vodicka, Ulrika Pettersson-Kymmer, Florentin Späth, Carolina Schinke, Frits Van Rhee, Patrick Sulem, Egil Ferkingstad, Grimur Hjorleifsson Eldjarn, Ulf-Henrik Mellqvist, Ingileif Jonsdottir, Gareth Morgan, Pieter Sonneveld, Anders Waage, Niels Weinhold, Hauke Thomsen, Asta Försti, Markus Hansson, Annette Juul-Vangsted, Unnur Thorsteinsdottir, Kari Hemminki, Martin Kaiser, Thorunn Rafnar, Kari Stefansson, Richard Houlston, Björn Nilsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 case
Externí odkaz:
https://doaj.org/article/45458eb3feec4e09b1c186e45ec468d5
Autor:
C David Wood, Hildegonda Veenstra, Sarika Khasnis, Andrea Gunnell, Helen M Webb, Claire Shannon-Lowe, Simon Andrews, Cameron S Osborne, Michelle J West
Publikováno v:
eLife, Vol 5 (2016)
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus
Externí odkaz:
https://doaj.org/article/d0168bf945bb4d54b7a76064f2dbc58e
Autor:
Sandra N Schlick, C David Wood, Andrea Gunnell, Helen M Webb, Sarika Khasnis, Aloys Schepers, Michelle J West
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28638 (2011)
Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV lat
Externí odkaz:
https://doaj.org/article/188f6d451de149edb5eb8f2f60f54f2e
Autor:
Michelle J. West, Andrea Gunnell, C. David Wood, Thomas Carvell, Cameron S. Osborne, Opeoluwa O. Ojeniyi
The oncogenic microRNA-155 (miR-155) is the most frequently upregulated miRNA in Epstein-Barr virus (EBV)-positive B cell malignancies and is upregulated in other non-viral lymphomas. Both the EBV nuclear antigen 2 (EBNA2), and B cell transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdde14df0e6bd768538c8c7b4b3e69e4
https://doi.org/10.1101/311886
https://doi.org/10.1101/311886
Autor:
C David, Wood, Thomas, Carvell, Andrea, Gunnell, Opeoluwa O, Ojeniyi, Cameron, Osborne, Michelle J, West
Publikováno v:
Journal of Virology
The oncogenic microRNA (miRNA) miR-155 is the most frequently upregulated miRNA in Epstein-Barr virus (EBV)-positive B cell malignancies and is upregulated in other nonviral lymphomas. Both EBV nuclear antigen 2 (EBNA2) and the B cell transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd3e7b456d5d32597d6893dedf2247e0
https://pubmed.ncbi.nlm.nih.gov/30655383
https://pubmed.ncbi.nlm.nih.gov/30655383
Autor:
Michelle J. West, Claire Shannon-Lowe, C. David Wood, Simon Andrews, Helen M. Webb, Andrea Gunnell, Cameron S. Osborne, Hildegonda Veenstra, Sarika Khasnis
Publikováno v:
Wood, C D, Veenstra, H, Khasnis, S, Gunnell, A, Webb, H M, Shannon-Lowe, C, Andrews, S, Osborne, C S & West, M J 2016, ' MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs ', eLife, vol. 5, e18270 . https://doi.org/10.7554/elife.18270
eLife
eLife, Vol 5 (2016)
eLife
eLife, Vol 5 (2016)
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dac399bc0672618c84eb5030aedaa72
https://kclpure.kcl.ac.uk/ws/files/94550015/MYC_activation_and_BCL2L11_WOOD_Published1August2016_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/94550015/MYC_activation_and_BCL2L11_WOOD_Published1August2016_GOLD_VoR_CC_BY_.pdf
Autor:
Hildegonda Veenstra, Helen M. Webb, Andrea Gunnell, Claire Shannon-Lowe, C. David Wood, Michelle J. West, Cameron S. Osborne, Sarika Khasnis, Simon Andrews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45bf0b8f795416c928b75a253dd54473
https://doi.org/10.7554/elife.18270.023
https://doi.org/10.7554/elife.18270.023
Autor:
Darren Le Grand, Jessica Hudson, Hitesh Patel, Simon E. Ward, Andrea Gunnell, Lewis E. Pennicott, Katie Duffell, Jessica A. Downs, Jessica R Booth, Kay Osborn
Publikováno v:
Cancer Research. 78:2907-2907
Gene expression frequently requires the dynamic remodelling of the chromatin architecture to orchestrate the assembly of transcriptional protein complexes at the promoter sites of DNA. Chromatin remodelling complexes are multicomponent proteins that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65316d5effbdf4c1fef8ab9a4393b480
https://doi.org/10.1158/1538-7445.am2018-2907
https://doi.org/10.1158/1538-7445.am2018-2907
Publikováno v:
Biochemical Society Transactions. 36:625-628
The EBNA 2 (Epstein–Barr nuclear antigen 2) transcription factor is essential for B-cell transformation by the cancer-associated EBV (Epstein–Barr virus) and for the continuous proliferation of infected cells. EBNA 2 activates transcription from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dd57ffa775f414c72474593e79cf90
https://doi.org/10.1042/bst0360625
https://doi.org/10.1042/bst0360625
Autor:
C. David Wood, Michelle J. West, Andrea Gunnell, Sarika Khasnis, Helen M. Webb, Aloys Schepers, Sandra N. Schlick
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28638 (2011)
PLoS ONE
PLoS ONE
Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV lat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df877256cd09c02ece13e5490d7b129a
http://europepmc.org/articles/PMC3232240?pdf=render
http://europepmc.org/articles/PMC3232240?pdf=render