Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Andrea, Amalfitano"'
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract Background Multiple sclerosis (MS) is a chronic, debilitating condition characterized by CNS autoimmunity stemming from a complex etiology involving both environmental and genetic factors. Our current understanding of MS points to dysregulat
Externí odkaz:
https://doaj.org/article/c1243fae00384f15ace6980e927d20ed
Autor:
Patrick O'Connell, Maja K. Blake, Yuliya Pepelyayeva, Sean Hyslop, Sarah Godbehere, Ariana M. Angarita, Cristiane Pereira-Hicks, Andrea Amalfitano, Yasser A. Aldhamen
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 180-193 (2022)
Targeted modulation of the immune system against tumors can achieve responses in otherwise refractory cancers, which has spurred efforts aimed at optimizing such strategies. To this end, we have previously investigated cancer immunotherapy approaches
Externí odkaz:
https://doaj.org/article/23d4b1ea712749bebc6abd8840efdf56
Autor:
Maja K. Blake, Patrick O’Connell, Yuliya Pepelyayeva, Sarah Godbehere, Yasser A. Aldhamen, Andrea Amalfitano
Publikováno v:
BMC Immunology, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background In addition to its role in antigen presentation, recent reports establish a new role for endoplasmic reticulum aminopeptidase 1 (ERAP1) in innate immunity; however, the mechanisms underlying these functions are not fully defined.
Externí odkaz:
https://doaj.org/article/d7d881aaa7c141a5985145252aba807e
Publikováno v:
Bio-Protocol, Vol 9, Iss 13 (2019)
Monocyte infection by HIV-1 is an important component of chronic HIV pathogenesis. Following infection by HIV-1, monocytes are able to cross the blood brain barrier and set up a viral reservoir in the central nervous system. Additionally, in the sett
Externí odkaz:
https://doaj.org/article/a0a2341bf25d4f56a8bd57c5dfa88c98
Autor:
Timothy M. Clay, H. Kim Lyerly, Michael A. Morse, Andrea Amalfitano, Gayathri Devi, Amy Hobeika, William Barry, Jeffrey Marks, Neil Spector, Wenle Xia, Dong-Wan Kim, Sharon Peplinski, Xiao-Yi Yang, Gangjun Lei, Oliver Glass, Takuya Osada, Junping Wei, Zachary C. Hartman
Purpose: Overexpression of the breast cancer oncogene HER2 correlates with poor survival. Current HER2-directed therapies confer limited clinical benefits and most patients experience progressive disease. Because refractory tumors remain strongly HER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6ac360f8f5c8a5381395d6c60f3fc6
https://doi.org/10.1158/1078-0432.c.6518551.v1
https://doi.org/10.1158/1078-0432.c.6518551.v1
Publikováno v:
Vaccines, Vol 7, Iss 4, p 184 (2019)
The signaling lymphocytic activation molecule (SLAM) family of receptors are expressed on the majority of immune cells. These receptors often serve as self-ligands, and play important roles in cellular communication and adhesion, thus modulating immu
Externí odkaz:
https://doaj.org/article/3b8d553d37ec47bc8b305f97b96fa83a
Autor:
Andrea Amalfitano, Sergey S. Seregin
Publikováno v:
Viruses, Vol 2, Iss 9, Pp 2013-2036 (2010)
Adenovirus (Ad) based gene transfer vectors continue to be the platform of choice for an increasing number of clinical trials worldwide. In fact, within the last five years, the number of clinical trials that utilize Ad based vectors has doubled, ind
Externí odkaz:
https://doaj.org/article/2786f2b91289492eb8371f38814daf8b
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 207(12)
Hundreds of genes have been linked to multiple sclerosis (MS); yet, the underlying mechanisms behind these associations have only been investigated in a fraction of cases. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an endoplasmic reticulum–l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfba8e357e4a64ec522960e18702126
https://pubmed.ncbi.nlm.nih.gov/34810226
https://pubmed.ncbi.nlm.nih.gov/34810226
Autor:
Andrea Amalfitano, Robert B. Crawford, Michael D. Rizzo, Sera Sermet, Anthony Bach, Norbert E. Kaminski
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:191-201
Cannabis is widely used in the United States, with an estimated prevalence of 9.5%. Certain cannabinoids in Cannabis sativa, Δ9-tetrahydrocannabinol (THC) in particular, possess immune-modulating and anti-inflammatory activity. Depending on the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c62e08978f55f0bf75e50c17ac9f1627
https://doi.org/10.1124/jpet.119.260661
https://doi.org/10.1124/jpet.119.260661
SLAMF7 Is a Critical Negative Regulator of IFN-α–Mediated CXCL10 Production in Chronic HIV Infection
Autor:
Patrick O'Connell, Maja K Blake, Yasser A. Aldhamen, Michael D. Rizzo, Andrea Amalfitano, Yuliya Pepelyayeva, Linda Dale, Norbert E. Kaminski, Peter Gulick, Cristiane Pereira-Hicks, Sarah Godbehere, Robert B. Crawford, Sean Hyslop
Publikováno v:
The Journal of Immunology. 202:228-238
Current advances in combined antiretroviral therapy have rendered HIV infection a chronic, manageable disease; however, the problem of persistent immune activation still remains despite treatment. The immune cell receptor SLAMF7 has been shown to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaca4bf6eeca147cc959e5ece5f3101
https://doi.org/10.4049/jimmunol.1800847
https://doi.org/10.4049/jimmunol.1800847