Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andre Stanlie"'
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002675 (2012)
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase (AID), can be divided into two phases: DNA cleavage of the switch (S) regions and the joining of the cleaved ends of the different S regions. Here, we show that the DS
Externí odkaz:
https://doaj.org/article/386da680350544c887490df3abdc54ec
Autor:
Andre Stanlie
Kyoto University (京都大学)
0048
甲第16746号
医科博第31号
新制||医科||3(附属図書館)
29421
学位規則第4条第1項該当
0048
甲第16746号
医科博第31号
新制||医科||3(附属図書館)
29421
学位規則第4条第1項該当
Externí odkaz:
http://hdl.handle.net/2433/157489
Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition
Autor:
Afzal Husain, Andre Stanlie, Tasuku Honjo, Mikiyo Nakata, Hisaaki Taniguchi, Takako Taniguchi, Samiran Mondal, Farazul Haque, Nasim A. Begum
Publikováno v:
EMBO J
Antibody class switch recombination (CSR) is a locus-specific genomic rearrangement mediated by switch (S) region transcription, activation-induced cytidine deaminase (AID)-induced DNA breaks, and their resolution by non-homologous end joining (NHEJ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ab4d2e1541ad4729b379699080ec77
https://europepmc.org/articles/PMC8204862/
https://europepmc.org/articles/PMC8204862/
Autor:
Momoko Ishikawa, André Nussenzweig, Peter J. McKinnon, Michelle E. Ehrlich, Andre Stanlie, Nancy Wong, Wei Wu, Frida Belinky, Dali Zong, Kenta Shinoda, Lavinia C. Dumitrache, Elsa Callen
The Shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and REV7, shields DNA double strand breaks (DSBs) from nucleolytic resection. The end-protecting activity of Shieldin promotes productive non-homologous end joining (NHEJ) in G1 but can threaten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a392b928dbc5ee9661a5b3c17a52908
https://doi.org/10.1101/2020.07.19.210773
https://doi.org/10.1101/2020.07.19.210773
Autor:
Jeremy M. Stark, Andrea K. Byrum, Elsa Callen, Nancy Wong, Andre Stanlie, Yaakov Maman, Nima Mosammaparast, Raphael Souza Pavani, Michael J. Kruhlak, Amanda Day, Wei Wu, André Nussenzweig, Lavinia C. Dumitrache, Peter J. McKinnon, Dali Zong, Andres Canela, Maria A. Blasco, Carlos Mendez-Dorantes, Paula Martinez, Momoko Ishikawa
Publikováno v:
Mol Cell
Summary 53BP1 activity drives genome instability and lethality in BRCA1-deficient mice by inhibiting homologous recombination (HR). The anti-recombinogenic functions of 53BP1 require phosphorylation-dependent interactions with PTIP and RIF1/shieldin
Autor:
Rajat Gupta, Takeo Narita, Elina Maskey, Jiri Lukas, André Nussenzweig, Chunaram Choudhary, Kumar Somyajit, Dimitris Typas, Andre Stanlie, Magdalena Kremer, Michael Lammers, Niels Mailand
Publikováno v:
Gupta, R, Somyajit, K, Narita, T, Maskey, E, Stanlie, A, Kremer, M, Typas, D, Lammers, M, Mailand, N, Nussenzweig, A, Lukas, J & Choudhary, C 2018, ' DNA repair network analysis reveals shielding as a key regulator of NEHJ and PARP inhibitor sensitivity ', Cell, vol. 173, no. 4, pp. 972-988.e23 . https://doi.org/10.1016/j.cell.2018.03.050
Cell
Gupta, R, Somyajit, K, Narita, T, Maskey, E, Stanlie, A, Kremer, M, Typas, D, Lammers, M, Mailand, N, Nussenzweig, A, Lukas, J & Choudhary, C 2018, ' DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity ', Cell, vol. 173, no. 4, pp. 972-988 . https://doi.org/10.1016/j.cell.2018.03.050
Cell
Gupta, R, Somyajit, K, Narita, T, Maskey, E, Stanlie, A, Kremer, M, Typas, D, Lammers, M, Mailand, N, Nussenzweig, A, Lukas, J & Choudhary, C 2018, ' DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity ', Cell, vol. 173, no. 4, pp. 972-988 . https://doi.org/10.1016/j.cell.2018.03.050
Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining proximity labeling with quantitative mass spectrometry, we generated high-resolution interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b9bc69094e6057675531565b223229
https://portal.findresearcher.sdu.dk/da/publications/cfb3f31f-6aa0-4c92-987b-40ee59281cd4
https://portal.findresearcher.sdu.dk/da/publications/cfb3f31f-6aa0-4c92-987b-40ee59281cd4
Publikováno v:
Proceedings of the National Academy of Sciences. 112:5791-5796
Activation-induced cytidine deaminase (AID) is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM). AID originally was postulated to function as an RNA-editing enzyme, based on its strong homology with apolipoprote
Publikováno v:
Cell Cycle
Somatic hypermutation (SHM) requires not only the expression of activation-induced cytidine deaminase, but also transcription in the target regions. However, how transcription guides activation-induced cytidine deaminase in targeting SHM to the Ig ge
Publikováno v:
Journal of Biological Chemistry. 287:32415-32429
H3K4me3 plays a critical role in the activation-induced cytidine deaminase (AID)-induced DNA cleavage of switch (S) regions in the immunoglobulin heavy chain (IgH) locus during class-switch recombination (CSR). The histone chaperone complex facilitat
Autor:
Yaakov Maman, Peter D. Aplan, Mirit I. Aladjem, Steven C. Pruitt, Sriram Sridharan, André Nussenzweig, Yan Jaszczyszyn, Olivier Hyrien, Mianmian Yin, Anthony T. Tubbs, Nancy Wong, Wei Wu, Christophe E. Redon, Niek van Wietmarschen, Andres Canela, Andre Stanlie, Haiqing Fu, Xia Wu, Amanda Day, Elsa Callen
Publikováno v:
Cell
Cell, 2018, 174 (5), pp.1127--1142.e19. ⟨10.1016/j.cell.2018.07.011⟩
Cell, 2018, 174 (5), pp.1127--1142.e19. ⟨10.1016/j.cell.2018.07.011⟩
International audience; Replication origins, fragile sites, and rDNA have been implicated as sources of chromosomal instability. However, the defining genomic features of replication origins and fragile sites are among the least understood elements o