Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Andre Pires da Cunha"'
Autor:
Andre Pires da Cunha, Howard L. Weiner
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
In recent years, our knowledge about immunoregulation and autoimmunity has significantly advanced, but nontoxic and more effective treatments for different inflammatory and autoimmune diseases are still lacking. Oral tolerance is of unique immunologi
Externí odkaz:
https://doaj.org/article/65592381d75b48a8a8b519636b5d97ed
Autor:
Henry Yim Wu, Francisco J Quintana, Andre Pires da Cunha, Benjamin T Dake, Thomas Koeglsperger, Sarah C Starossom, Howard L Weiner
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23618 (2011)
Type 1 regulatory T (Tr1) cells, characterized by the secretion of high levels of the anti-inflammatory cytokine interleukin-10 (IL-10), play an important role in the regulation of autoimmune diseases and transplantation. However, effective strategie
Externí odkaz:
https://doaj.org/article/bb678c61496945a39d237f82ec6f77a1
Autor:
Mai Fujiwara, Rafael M. Rezende, Duanduan Ma, Nathaniel P. Skillin, Stuart S. Levine, Brian C. Healy, Linqing Sun, Hadi Abou-El-Hassan, Lena R. Walton, Howard L. Weiner, Thais Garcias Moreira, Rajesh Krishnan, Galina Gabriely, Amee Patel, Gopal Murugaiyan, Andre Pires da Cunha, Dustin J. Donnelly, Shafiuddin Siddiqui
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103347-(2021)
iScience
iScience
Summary Myeloid suppressor cells promote tumor growth by a variety of mechanisms which are not fully characterized. We identified myeloid cells (MCs) expressing the latency-associated peptide (LAP) of TGF-β on their surface and LAPHi MCs that stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b082de3f2b62c24102cb96d1f627f36
https://doi.org/10.1016/j.isci.2021.103347
https://doi.org/10.1016/j.isci.2021.103347
Publikováno v:
The Journal of Immunology. 198:1202-1209
Oral administration of Ag induces regulatory T cells that express latent membrane-bound TGF-β (latency-associated peptide [LAP]) and have been shown to play an important role in the induction of oral tolerance. We developed an in vitro model to stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a54479d41c97f3e27d7c79edf7c67e8
https://doi.org/10.4049/jimmunol.1600921
https://doi.org/10.4049/jimmunol.1600921
Autor:
Fabrice Valette, Chantal Kuhn, Francisco J. Quintana, Rafael M. Rezende, Lucienne Chatenoud, Howard L. Weiner, Andre Pires da Cunha
Publikováno v:
J Autoimmun
CD3-specific monoclonal antibody (mAb) treats autoimmune disease in animal models and has shown promise in clinical trials of type 1 diabetes. Whereas intravenous administration of CD3-specific mAb acts primarily by transient depletion of activated e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cd681d0cd49ed5ef833994aa9d9eee
https://doi.org/10.1016/j.jaut.2016.10.001
https://doi.org/10.1016/j.jaut.2016.10.001
Autor:
Roopali Gandhi, Zhiyun Wei, Howard L. Weiner, Shirong Liu, Ron Cialic, Laurie E. Comstock, Andre Pires da Cunha, Rafael M. Rezende, Lynn Bry
Publikováno v:
Microbial Cell
Since their discovery in the early 90s, microRNAs (miRNAs), small non-coding RNAs, have mainly been associated with posttranscriptional regulation of gene expression on a cell-autonomous level. Recent evidence has extended this role by adding inter-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd85a436d39117b419e590150afa784c
Autor:
Brendan Kenyon, Nathaniel Skillin, Rafael M. Rezende, Andre Pires da Cunha, Lena Walton, Murugaiyan Gopal, Galina Gabriely, Howard L. Weiner
Publikováno v:
Cancer Immunology Research. 8:A85-A85
Immunotherapy that acts by counteracting the suppressive environment established by the tumor became a very promising approach for the treatment of cancer. Regulatory immune cells promote cancer by suppressing antitumor immune responses, but there ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73043723dad978c65d54f5eb1cb30661
https://doi.org/10.1158/2326-6074.tumimm18-a85
https://doi.org/10.1158/2326-6074.tumimm18-a85
Autor:
Howard L. Weiner, Vishal S. Vaidya, Nir Yosef, Nicole Joller, Andre Pires da Cunha, Sowmiya Kumaradevan, Gopal Murugaiyan, Lucien P. Garo, Amrendra Kumar Ajay
Publikováno v:
The Journal of clinical investigation
Accumulation of IL-17–producing Th17 cells is associated with the development of multiple autoimmune diseases; however, the contribution of microRNA (miRNA) pathways to the intrinsic control of Th17 development remains unclear. Here, we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2494209b762d0f61063921b017815105
Autor:
Ana Cristina Gomes-Santos, Ana Maria Caetano Faria, Samara Rabelo Medeiros, Rafael M. Rezende, Sylvia S. Amaral, Anderson Miyoshi, Rafael Pires Oliveira, Andrea C. Alves, Andre Pires da Cunha, Flavia G. Loli, Mauro Andrade Freitas Guimarães, Vasco Azevedo, Howard L. Weiner
Publikováno v:
Journal of Autoimmunity. 40:45-57
Heat shock proteins (Hsps) participate in the cellular response to stress and they are hiperexpressed in inflammatory conditions. They are also known to play a major role in immune modulation, controlling, for instance, autoimmune responses. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a6838fa600254473a35751ca2859db
https://doi.org/10.1016/j.jaut.2012.07.012
https://doi.org/10.1016/j.jaut.2012.07.012
Publikováno v:
The Journal of Immunology. 189:5277-5283
IL-9–producing Th9 cells have been associated with autoimmune diseases, such as experimental autoimmune encephalitis. However, the factors that negatively regulate Th9 cells during autoimmune inflammation are unclear. In this article, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9e76541f9872ccffdf3b5cf7ac6f1b
https://doi.org/10.4049/jimmunol.1200808
https://doi.org/10.4049/jimmunol.1200808