Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Andre Mitschler"'
Autor:
Valentin Bauer, Yves Nominé, Natacha Rochel, Jozica Dolenc, Gergő Gógl, Vladimir Yu. Torbeev, Gilles Travé, Andre Mitschler, Boris Schmidtgall, Judit Osz, Alexandra Cousido-Siah, Camille Kostmann, Bruno Kieffer
Publikováno v:
Chemical Science
Chemical Science, The Royal Society of Chemistry, 2021, 12 (3), pp.1080-1089. ⟨10.1039/d0sc04482b⟩
Chemical Science, 2021, 12 (3), pp.1080-1089. ⟨10.1039/D0SC04482B⟩
Chemical Science, 12 (3)
Chemical Science, The Royal Society of Chemistry, 2021, 12 (3), pp.1080-1089. ⟨10.1039/d0sc04482b⟩
Chemical Science, 2021, 12 (3), pp.1080-1089. ⟨10.1039/D0SC04482B⟩
Chemical Science, 12 (3)
Intrinsically disordered proteins (IDPs) constitute a large portion of “Dark Proteome” – difficult to characterize or yet to be discovered protein structures. Here we used conformationally constrained α-methylated amino acids to bias the confo
Autor:
Jennifer Savoy, Alberto Podjarny, Eduardo Howard, G. Erik Jagdmann, Alexandra Cousido-Siah, Olga Potapova, Michael C. Van Zandt, Andre Mitschler, Minkoo Ji, Darren Whitehouse, Anna Marie Pyle
Publikováno v:
Journal of Medicinal Chemistry. 62:8164-8177
Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of (3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogues with u...
Autor:
Alessandra Meli, Philippe Compain, Eduardo Howard, Irene Izzo, Alberto Podjarny, Hugo Álvarez, Mathieu L. Lepage, Alexandra Cousido-Siah, Anne Bodlenner, Jérémy P. Schneider, Andre Mitschler
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2018, 57 (27), pp.8002-8006. ⟨10.1002/anie.201801202⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2018, 57 (27), pp.8002-8006. ⟨10.1002/anie.201801202⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Multivalent design of glycosidase inhibitors is a promising strategy for the treatment of diseases involving enzymatic hydrolysis of glycosidic bonds in carbohydrates. An essential prerequisite for successful applications is the atomic‐level unders
Autor:
Michael C, Van Zandt, G Erik, Jagdmann, Darren L, Whitehouse, Minkoo, Ji, Jennifer, Savoy, Olga, Potapova, Alexandra, Cousido-Siah, Andre, Mitschler, Eduardo I, Howard, Anna Marie, Pyle, Alberto D, Podjarny
Publikováno v:
Journal of medicinal chemistry. 62(17)
Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of (3
Autor:
Alexandra Cousido-Siah, Lucas A. Defelipe, Javier Santos, W.M. Valsecchi, Andre Mitschler, Alberto Podjarny, José M. Delfino
Publikováno v:
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2016, 1864 (6), pp.655-666. ⟨10.1016/j.bbapap.2016.03.005⟩
BBA-Biochimica et Biophysica Acta, Elsevier, 2016, 1864 (6), pp.655-666. ⟨10.1016/j.bbapap.2016.03.005⟩
Hypoxanthine phosphoribosyl transferase from Trypanosoma cruzi (TcHPRT) is a critical enzyme for the survival of the parasite. This work demonstrates that the full-length form in solution adopts a stable and enzymatically active tetrameric form, exhi
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:129-142
A unique zinc domain found in all of the identified members of the lipase family I.5 is surrounded by two conserved tryptophans (W61 and W212). In this study, we investigated the role of these hydrophobic residues in thermostability and thermoactivit
Autor:
Dimitris Kletsas, Sergio Porté, F.X. Ruiz, Jaume Farrés, Joan Gimenez-Dejoz, Harris Pratsinis, Isidro Crespo, Alberto Podjarny, Kamel Metwally, Alexandra Cousido-Siah, Andre Mitschler, Xavier Parés
Publikováno v:
European journal of medicinal chemistry. 152
Human aldose reductase (AKR1B1, AR) is a key enzyme of the polyol pathway, catalyzing the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic condition. Indeed, AKR1B1 overexpression is related to diabetes seco
Autor:
Piotr L. Sklepkiewicz, Czestkowski Wojciech J, Bruce R. Conway, Ryan Sheeler, Tom Noonan, Alexandra Cousido-Siah, Alberto Podjarny, Sylwia Olejniczak, Agnieszka Zagozdzon, Jacek Olczak, Anna Jedrzejczak, Andre Mitschler, Adam Golebiowski, Paul Beckett, Firas Fadel, Karolina Dzwonek, Marzena Mazur, William M. Hungerford, Barbara Dymek, Robert Koralewski, Jakub Golab, Keyvan Mahboubi
Publikováno v:
Journal of Medicinal Chemistry
This article highlights our work toward the identification of a potent, selective, and efficacious acidic mammalian chitinase (AMCase) inhibitor. Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1),
Autor:
Alberto Podjarny, Martín Ezequiel Noguera, Andre Mitschler, Alexandra Cousido-Siah, Juan B. Rigal, Javier Santos, Ernesto A. Roman
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 20:653-664
Frataxin is an evolutionary conserved protein that participates in iron metabolism. Deficiency of this small protein in humans causes a severe neurodegenerative disease known as Friedreich's ataxia. A number of studies indicate that frataxin binds ir
Autor:
Alberto Podjarny, Diego S. Vazquez, Eduardo I. Howard, Andre Mitschler, Javier Santos, Alexandra Cousido-Siah, Gerardo Ferrer-Sueta, William A. Agudelo, Rodolfo M. Rasia, Bruno Manta, Martín Ezequiel Noguera
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
COLIBRI
Universidad de la República
instacron:Universidad de la República
Scientific Reports
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
COLIBRI
Universidad de la República
instacron:Universidad de la República
Scientific Reports
Thioredoxin is a ubiquitous small protein that catalyzes redox reactions of protein thiols. Additionally, thioredoxin from E. coli (EcTRX) is a widely-used model for structure-function studies. In a previous paper, we characterized several single-poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683b63aa8652db4266bbaa7c307fc385
https://www.nature.com/articles/srep42343
https://www.nature.com/articles/srep42343