Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2

Autor: Petur B. Juliusson, Ingvild S. Bruserud, Ninnie Helen Bakken Oehme, Andre Madsen, Ingvild H. Forthun, Melissa Balthasar, Karen Rosendahl, Kristin Viste, Astanand Jugessur, Lawrence M. Schell, Robert Bjerknes, Mathieu Roelants

Publikováno v: Annals of Human Biology, Vol 50, Iss 1, Pp 226-235 (2023)

Background The Bergen Growth Study 2 (BGS2) aims to characterise somatic and endocrine changes in healthy Norwegian children using a novel methodology. Subjects and methods A cross-sectional sample of 1285 children aged 6–16 years was examined in 2

Externí odkaz: https://doaj.org/article/a12bdb9b0d9840cb844b85843cfb8536

The Application of Principal Component Analysis on Clinical and Biochemical Parameters Exemplified in Children With Congenital Adrenal Hyperplasia

Autor: Marie Lindhardt Ljubicic, Andre Madsen, Anders Juul, Kristian Almstrup, Trine Holm Johannsen

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

PurposePrincipal component analysis (PCA) is a mathematical model which simplifies data into new, combined variables. Optimal treatment of pediatric congenital adrenal hyperplasia (CAH) remains a challenge and requires evaluation of all biochemical a

Externí odkaz: https://doaj.org/article/2ca3d85b39154a32baa3f430250be58e

Reference curves for pediatric endocrinology: leveraging biomarker z-scores for clinical classifications

Autor: Andre Madsen, Bjørg Almås, Ingvild S Bruserud, Ninnie Helen Bakken Oehme, Christopher Sivert Nielsen, Mathieu Roelants, Thomas Hundhausen, Marie Lindhardt Ljubicic, Robert Bjerknes, Gunnar Mellgren, Jørn V Sagen, Pétur B Juliusson, Kristin Viste

Publikováno v: Journal of Clinical Endocrinology and Metabolism (JCEM)
dgac155

Context Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential measurements onto a chart. Refere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce913f37ac9492bcd2e93a3e04839ca9
https://doi.org/10.1210/clinem/dgac155

Statistical models for pediatric endocrinology

Autor: Andre Madsen

Background: Modelling references for biomarkers as reference curves enables calculation of patient z-scores that are adjusted for both gender and covariance with age during childhood.Aim: To establish biomarker reference curves using the ‘LMS’ me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b32e9b45f7cf03ff607ffcc39ab80fbe
https://doi.org/10.21203/rs.3.rs-1109851/v1

Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance

Autor: Mona Synnøve Bjune, Christian Busch, Andre Madsen, Aron Willems, Peter Jacobson, Linn Skartveit, Jan-Inge Bjune, Matthias Blüher, Vidar M. Steen, Bjørn G. Nedrebø, Laurence Dyer, Gunnar Mellgren, Peter Arner, Håvard Luong Thorsen, Melina Claussnitzer, Mikael Rydén, Ottar Nygård, Even Fjære, Ståle Ellingsen, Hans Jørgen Nielsen, Per-Arne Svensson, Jørn V. Sagen, Adrian McCann, Lise Madsen, Divya Sri Priyanka Tallapragada, Johan Fernø, Villy Våge, Simon N. Dankel, Regine Å. Jersin

Publikováno v: Jersin, R Å, Tallapragada, D S P, Madsen, A, Skartveit, L, Fjære, E, McCann, A, Dyer, L, Willems, A, Bjune, J-I, Bjune, M S, Våge, V, Nielsen, H J, Thorsen, H L, Nedrebø, B G, Busch, C, Steen, V M, Blüher, M, Jacobson, P, Svensson, P-A, Fernø, J, Rydén, M, Arner, P, Nygård, O, Claussnitzer, M, Ellingsen, S, Madsen, L, Sagen, J V, Mellgren, G & Dankel, S N 2021, ' Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance ', Diabetes, vol. 70, no. 3, pp. 680-695 . https://doi.org/10.2337/db20-0096
Diabetes

Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose expression of the small neutral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec6bfe94fbcbe478d53ce19711b014a
https://pubmed.ncbi.nlm.nih.gov/33408126