Výsledky vyhledávání - "Andre L Moreira"

Akademický článek

Expression of PD-L1 and other immunotherapeutic targets in thymic epithelial tumors.

Autor: Kathryn C Arbour, Jarushka Naidoo, Keith E Steele, Ai Ni, Andre L Moreira, Natasha Rekhtman, Paul B Robbins, Joyson Karakunnel, Andreas Rimner, James Huang, Gregory J Riely, Matthew D Hellmann

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182665 (2017)

The thymus is a critical organ for the development of the adaptive immune system and thymic epithelial tumors (TETs; thymomas and thymic carcinomas) are often associated with auto-immune paraneoplastic conditions. However, the immunobiology of TETs i

Externí odkaz: https://doaj.org/article/dab17a34446b4546aa9bc399f5b11582

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Akademický článek

Distance in cancer gene expression from stem cells predicts patient survival.

Autor: Markus Riester, Hua-Jun Wu, Ahmet Zehir, Mithat Gönen, Andre L Moreira, Robert J Downey, Franziska Michor

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173589 (2017)

The degree of histologic cellular differentiation of a cancer has been associated with prognosis but is subjectively assessed. We hypothesized that information about tumor differentiation of individual cancers could be derived objectively from cancer

Externí odkaz: https://doaj.org/article/91ed221401b54d5fb9766fa47c71ff87

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Akademický článek

Mapping the landscape of histomorphological cancer phenotypes using self-supervised learning on unannotated pathology slides

Autor: Adalberto Claudio Quiros, Nicolas Coudray, Anna Yeaton, Xinyu Yang, Bojing Liu, Hortense Le, Luis Chiriboga, Afreen Karimkhan, Navneet Narula, David A. Moore, Christopher Y. Park, Harvey Pass, Andre L. Moreira, John Le Quesne, Aristotelis Tsirigos, Ke Yuan

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)

Abstract Cancer diagnosis and management depend upon the extraction of complex information from microscopy images by pathologists, which requires time-consuming expert interpretation prone to human bias. Supervised deep learning approaches have prove

Externí odkaz: https://doaj.org/article/24019f1068da441492cffc896558e017

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Akademický článek

Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Approximately 30% of early-stage lung adenocarcinoma patients present with disease progression after successful surgical resection. Despite efforts of mapping the genetic landscape, there has been limited success in discovering predictive bi

Externí odkaz: https://doaj.org/article/326ae301e3024de2b6652801e0ebede8

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Akademický článek

KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance

Publikováno v: Cell Reports, Vol 42, Iss 11, Pp 113295- (2023)

Summary: Lung cancer treatment has benefited greatly through advancements in immunotherapies. However, immunotherapy often fails in patients with specific mutations like KEAP1, which are frequently found in lung adenocarcinoma. We established an anti

Externí odkaz: https://doaj.org/article/240bdf74cb4547dea3fb1640afd7bcf5

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Akademický článek

Correlative analysis from a phase I clinical trial of intrapleural administration of oncolytic vaccinia virus (Olvi-vec) in patients with malignant pleural mesothelioma

Autor: Navin K. Chintala, Jennie K. Choe, Erin McGee, Rebecca Bellis, Jasmeen K. Saini, Srijita Banerjee, Andre L. Moreira, Marjorie G. Zauderer, Prasad S. Adusumilli, Valerie W. Rusch

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundThe attenuated, genetically engineered vaccinia virus has been shown to be a promising oncolytic virus for the treatment of patients with solid tumors, through both direct cytotoxic and immune-activating effects. Whereas systemically admini

Externí odkaz: https://doaj.org/article/3273ec9012d64f429fc5aadf18ca215f

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Akademický článek

Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project

Autor: Robert Camp, Maxwell L. Smith, Brandon T. Larsen, Anja C. Roden, Carol Farver, Andre L. Moreira, Richard Attanoos, Raghavendra Pillappa, Irene Sansano, Alexandre Todorovic Fabro, Robert J. Homer

Publikováno v: BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-10 (2021)

Abstract Background Current interstitial lung disease (ILD) diagnostic guidelines assess criteria across clinical, radiologic and pathologic domains. Significant interobserver variation in histopathologic evaluation has previously been shown but the

Externí odkaz: https://doaj.org/article/59d0209d00e74ffe976371282aa60c7d

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Akademický článek

Lessons Learned From an Anatomic Pathology Department in a Large Academic Medical Center at the Epicenter of COVID-19

Autor: Tamar C. Brandler MD, MS, Dana Warfield MPA, CPHQ, Esther Adler MD, Aylin Simsir MD, Marie-Ange Exilhomme MA, CT (ASCP), Andre L. Moreira MD, Kristen Thomas MD, Joan Cangiarella MD

Publikováno v: Academic Pathology, Vol 8 (2021)

Many state-wide, city-wide, and hospital-wide changes have been implemented due to the ongoing COVID-19 crisis. We describe lessons learned in an anatomic pathology division at a tertiary care center during the peak of the COVID-19 pandemic in the ho

Externí odkaz: https://doaj.org/article/1d73e30eced24289b179f03a04d9c8d9

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