Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andre Kubler"'
Autor:
Eduardo P. Amaral, Nicolas Riteau, Mahtab Moayeri, Nolan Maier, Katrin D. Mayer-Barber, Rosana M. Pereira, Silvia L. Lage, Andre Kubler, William R. Bishai, Maria R. D’Império-Lima, Alan Sher, Bruno B. Andrade
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Lysosomal cathepsin B (CTSB) has been proposed to play a role in the induction of acute inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for NLRP3-inflammasome assembly and, consequently, for mature IL-1β gene
Externí odkaz:
https://doaj.org/article/05a9b43a81de41989607b87fe438516b
Autor:
Neesha Rockwood, Diego L. Costa, Eduardo P. Amaral, Elsa Du Bruyn, Andre Kubler, Leonardo Gil-Santana, Kiyoshi F. Fukutani, Charles A. Scanga, JoAnne L. Flynn, Sharon H. Jackson, Katalin A. Wilkinson, William R. Bishai, Alan Sher, Robert J. Wilkinson, Bruno B. Andrade
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The antioxidant enzyme heme oxygenase-1 (HO-1) is implicated in the pathogenesis of tuberculosis (TB) and has been proposed as a biomarker of active disease. Nevertheless, the mechanisms by which Mycobacterium tuberculosis (Mtb) induces HO-1 as well
Externí odkaz:
https://doaj.org/article/2c92fea5ca184cb4a765335c9bb91228
Autor:
Shichun Lun, David Miranda, Andre Kubler, Haidan Guo, Mariama C. Maiga, Kathryn Winglee, Shaaretha Pelly, William R. Bishai
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT Most β-lactam antibiotics are ineffective against Mycobacterium tuberculosis due to the microbe’s innate resistance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has prompted interest to repurpos
Externí odkaz:
https://doaj.org/article/e2d9cd97723049a59e324f884a5cd039
Autor:
Andre Kubler, Sanjay K. Jain, Michael E. Urbanowski, Mariah H. Klunk, Supriya Pokkali, William R. Bishai, Paul T. Elkington, Alvaro A. Ordonez, Julian Sanchez-Bautista
Publikováno v:
The Journal of Infectious Diseases. 219:633-636
Matrix metalloproteinases (MMPs) degrade extracellular matrix and are implicated in tuberculosis pathogenesis and cavitation. In particular, MMP-7 is induced by hypoxia and highly expressed around pulmonary cavities of Mycobacterium tuberculosis–in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795abb954a14a5c36e54ea867ee95b6d
https://doi.org/10.1093/infdis/jiy373
https://doi.org/10.1093/infdis/jiy373
Autor:
William R. Bishai, Elizabeth A. Ihms, Michael E. Urbanowski, Andre Kubler, Kristina M. Bigelow, Paul T. Elkington
Publikováno v:
The Journal of Infectious Diseases. 218:53-63
BACKGROUND: Cavitation is a serious consequence of tuberculosis. We tested the hypothesis that repetitive exposure to the same total bacterial burden of Mycobacterium tuberculosis drives greater lung destruction than a single exposure. We also tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53585ddc44853c32bb29d21591776c0d
https://doi.org/10.1093/infdis/jiy127
https://doi.org/10.1093/infdis/jiy127
Autor:
Maria Irene Bellini, Andre Kubler
Modern healthcare needs to identify parameters for high-quality care. Quality improvement is the key for advancing in healthcare, and the new assessment tool shifts from a disease-centered outcome to a patient-centered outcome. Clinical outcome such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aba73e0525742190932aaa7aa83efcd
https://doi.org/10.4018/978-1-5225-4074-8.ch007
https://doi.org/10.4018/978-1-5225-4074-8.ch007
Autor:
Brian Luna, Andre Kubler, Nicole C. Ammerman, Alan Sher, Bruno B. Andrade, Paul T. Elkington, Marc K. Halushka, Jin Kyun Park, Kevin W. Bock, Michael E. Urbanowski, Marlene Orandle, Christer Larsson, Kathryn Winglee, William R. Bishai, Jon S. Friedland, Eduardo P. Amaral, Laurene S. Cheung
Publikováno v:
Journal of Infectious Diseases. 213:618-627
Cavitation in tuberculosis enables highly efficient person-to-person aerosol transmission. We performed transcriptomics in the rabbit cavitary tuberculosis model. Among 17 318 transcripts, we identified 22 upregulated proteases. Five type I collagena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2c923308e2b4a1ef27c50abdb41c3b
https://doi.org/10.1093/infdis/jiv458
https://doi.org/10.1093/infdis/jiv458
Autor:
Sanjay K. Jain, Colleen B. Jonsson, Awais Mansoor, Gabriela Kramer-Marek, Georgios Z. Papadakis, Andre Kubler, Brent Foster, Jayaram K. Udupa, Brian Luna, Jeremy V. Camp, Bappaditya Dey, Ziyue Xu, Ulas Bagci, William R. Bishai, Daniel J. Mollura
Publikováno v:
Medical Physics. 42:3896-3910
Purpose: To develop an automated pulmonary image analysis framework for infectious lung diseases in small animal models. Methods: The authors describe a novel pathological lung and airway segmentation method for small animals. The proposed framework
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82bc55e7ab87811096bd0db47ef69fdd
https://doi.org/10.1118/1.4921618
https://doi.org/10.1118/1.4921618
Autor:
Jay Burns, Jon S. Friedland, William R. Bishai, John C. Marshall, Kevin W. Bock, Alan Sher, Daniel J. Mollura, Bruno B. Andrade, Subash Babu, Kathryn Winglee, Nathella Pavan Kumar, Ulas Bagci, Nicole C. Ammerman, Sanjay K. Jain, Christer Larsson, Laurene S. Cheung, Bintou Ahmadou Ahidjo, Andre Kubler, Ziyue Xu, Paul T. Elkington, Marlene Orandle, Mariah H. Klunk, Brian Luna
Publikováno v:
The Journal of Pathology. 235:431-444
Active tuberculosis (TB) often presents with advanced pulmonary disease, including irreversible lung damage and cavities. Cavitary pathology contributes to antibiotic failure, transmission, morbidity and mortality. Matrix metalloproteinases (MMPs), i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6253dd2845c43755dc8818102a448325
https://doi.org/10.1002/path.4432
https://doi.org/10.1002/path.4432
Autor:
William R. Bishai, Andre Kubler, Brent Foster, Brian Luna, Sanjay K. Jain, Daniel J. Mollura, Ulas Bagci, Christer Larsson
Publikováno v:
The Journal of infectious diseases. 211(3)
The presence of cavitary lesions in patients with tuberculosis poses a significant clinical concern due to the risk of infectivity and the risk of antibiotic treatment failure. We describe 2 algorithms that use noninvasive positron emission tomograph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4273563141aacb331c04cbddb4f21a8e
https://pubmed.ncbi.nlm.nih.gov/25117755
https://pubmed.ncbi.nlm.nih.gov/25117755