Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Andre H. Apostolatos"'
Autor:
Mini P, Sajan, Michael, Leitges, Colin, Park, David M, Diamond, Jin, Wu, Barbara C, Hansen, Mildred A, Duncan, Christopher A, Apostolatos, Andre H, Apostolatos, Mark, Kindy, Robert V, Farese
Publikováno v:
Current Alzheimer Research. 18:941-955
Βackground: β-Amyloid precursor protein-cleaving enzyme-1 (BACE1) initiates the production of Aβ-peptides that form Aβ-plaque in Alzheimer’s disease. Methods: Reportedly, acute insulin treatment in normal mice, and hyperinsulinemia in high-fat-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9411aa5040f4fe071bf5c78795b2c3
https://doi.org/10.2174/1567205019666211222120448
https://doi.org/10.2174/1567205019666211222120448
Autor:
Samer S. Sansil, Christopher Apostolatos, Anthony Neuger, Mildred Acevedo-Duncan, Wishrawana S. Ratnayake, Andre H. Apostolatos, Marie Bourgeois
Publikováno v:
Anti-Cancer Drugs
Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma. Previous in-vitro studies have shown that 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad23eba6e67e75f3a211a7398f280aaa
https://doi.org/10.1097/cad.0000000000000694
https://doi.org/10.1097/cad.0000000000000694
Autor:
Tracess Smalley, Hla Win-Piazza, Loveleen Kang, Wishrawana S. Ratnayake, Christopher Apostolatos, Andre H. Apostolatos, Raoul Salup, Robert Hill, Mildred Acevedo-Duncan
Publikováno v:
International Journal of Oncology
Prostate cancer (PC) is the most common type of cancer among men. Aggressive and metastatic PC results in life- threatening tumors, and represents one of the leading causes of mortality in men. Previous studies of atypical protein kinase C isoforms (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a12a2b3cc018d0a3f935b8fa3658d5
http://europepmc.org/articles/PMC6192717
http://europepmc.org/articles/PMC6192717
Publikováno v:
International Journal of Oncology
Atypical protein kinase Cs (aPKC) are involved in cell cycle progression, tumorigenesis, cell survival and migration in many cancers. We believe that aPKCs play an important role in cell motility of melanoma by regulating cell signaling pathways and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4cc5a5e775b70a226a21a1f0562db82
https://doi.org/10.3892/ijo.2017.4131
https://doi.org/10.3892/ijo.2017.4131
Autor:
Jin Wu, Mildred Acevedo Duncan, Ursula Braun, Robert V. Farese, Colin Park, Christopher Apostolatos, Andre H. Apostolatos, David M. Diamond, Mark S. Kindy, Michael Leitges, Barbara C. Hansen, Mini P. Sajan
Publikováno v:
Metabolism. 104:154112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d35491f1925eb0fdf626d6412f4d643
https://doi.org/10.1016/j.metabol.2019.12.058
https://doi.org/10.1016/j.metabol.2019.12.058
Autor:
Andre H. Apostolatos, S M Anisul Islam, Mildred Acevedo-Duncan, Christopher Apostolatos, Tracess Smalley
Publikováno v:
Oncology Letters
It is estimated that breast cancer will be the second leading cause of cancer-associated mortality in women in 2018. Previous research has demonstrated that the atypical protein kinase C-ζ (PKC-ζ) is a component of numerous dysregulated pathways in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d99bad97c82ed539121eb320c8621a
https://doi.org/10.3892/ol.2018.9792
https://doi.org/10.3892/ol.2018.9792
Autor:
Mildred Acevedo-Duncan, Wishrawana S. Ratnayke, Sloan Breedy, Andre H. Apostolatos, Christopher Apostolatos
Publikováno v:
World Academy of Sciences Journal.
Regardless of abundant efforts to enhance primary prevention and early detection, the number of melanoma cases in the United States has increased steadily over the past 15 years, thus greatly affecting public health and the economy. In previous studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f35e27bd7ac8398389422de2e37b15
https://doi.org/10.3892/wasj.2018.2
https://doi.org/10.3892/wasj.2018.2
Autor:
Wishrawana S. Ratnayake, Ryan J. Schutte, David A. Ostrov, Andre H. Apostolatos, Mildred Acevedo-Duncan, Christopher Apostolatos, Monica A. Huynh
Publikováno v:
Cell Adhesion & Migration
Melanoma is one of the fastest growing cancers in the United States and is accompanied with a poor prognosis owing to tumors being resistant to most therapies. Atypical protein kinase Cs (aPKC) are involved in malignancy in many cancers. We previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d33abe0f820a850f769bc3a7213e8a
https://pubmed.ncbi.nlm.nih.gov/29781749
https://pubmed.ncbi.nlm.nih.gov/29781749
Autor:
Andre H. Apostolatos, Mishka S Peart, Shijie Song, Sandra Acosta, James E. Watson, Niketa A. Patel, Paula C. Bickford, Denise R. Cooper
Publikováno v:
Journal of Biological Chemistry. 287:9299-9310
Insulin signaling pathways in the brain regulate food uptake and memory and learning. Insulin and protein kinase C (PKC) pathways are integrated and function closely together. PKC activation in the brain is essential for learning and neuronal repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ade5c4fdb01f6f8fb9c72056c455b6
https://doi.org/10.1074/jbc.m111.313080
https://doi.org/10.1074/jbc.m111.313080
Autor:
Andre H. Apostolatos, Fernando L. Vale, Juan Sanchez-Ramos, James E. Watson, Hercules Apostolatos, Shijie Song, Niketa A. Patel, Timothy A. Vickers, Denise R. Cooper
Publikováno v:
Journal of Biological Chemistry. 285:25987-25995
Vitamin A metabolite, all-trans-retinoic acid (RA), induces cell growth, differentiation, and apoptosis and has an emerging role in gene regulation and alternative splicing events. Protein kinase Cdelta (PKCdelta), a serine/threonine kinase, has a ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30586efa7591810642cd99f976a449fa
https://doi.org/10.1074/jbc.m110.100735
https://doi.org/10.1074/jbc.m110.100735