Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andre Ghetti"'
Autor:
Phuong T Nguyen, Hai M Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Publikováno v:
eLife, Vol 11 (2022)
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://doaj.org/article/61a7e4bc52cf45b98b9c1e6f378c835a
Autor:
Anh Tuan Ton, William Nguyen, Katrina Sweat, Yannick Miron, Eduardo Hernandez, Tiara Wong, Valentyna Geft, Andrew Macias, Ana Espinoza, Ky Truong, Lana Rasoul, Alexa Stafford, Tamara Cotta, Christina Mai, Tim Indersmitten, Guy Page, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Late sodium current (late INa) inhibition has been proposed to suppress the incidence of arrhythmias generated by pathological states or induced by drugs. However, the role of late INa in the human heart is still poorly understood. We theref
Externí odkaz:
https://doaj.org/article/9370b3fc5ae4452d944997c5ebf6e262
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
To assess drug-induced pro-arrhythmic risk, especially Torsades de Pointe (TdP), new models have been proposed, such as in-silico modeling of ventricular action potential (AP) and stem cell-derived cardiomyocytes (SC-CMs). Previously we evaluated the
Externí odkaz:
https://doaj.org/article/ec8a7ab55f82419091b2e536c293fa1a
Autor:
Nathalie Nguyen, William Nguyen, Brynna Nguyenton, Phachareeya Ratchada, Guy Page, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Cardiac safety remains the leading cause of drug development discontinuation. We developed a human cardiomyocyte-based model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic and
Externí odkaz:
https://doaj.org/article/97038ffc628241a5a180e8e55611c140
Autor:
Oliver J. Britton, Najah Abi-Gerges, Guy Page, Andre Ghetti, Paul E. Miller, Blanca Rodriguez
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Background:In silico modeling could soon become a mainstream method of pro-arrhythmic risk assessment in drug development. However, a lack of human-specific data and appropriate modeling techniques has previously prevented quantitative comparison of
Externí odkaz:
https://doaj.org/article/f9f567a66ef045c5a3dc158a52de5b6a
Autor:
Hai M Nguyen, Phuong T Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33893d32f016b01de0ad9310c1b61a77
https://doi.org/10.7554/elife.81727.sa2
https://doi.org/10.7554/elife.81727.sa2
Autor:
Hai M Nguyen, Phuong T Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0988b85ef375b455a45538fdc58e6c47
https://escholarship.org/uc/item/35r029z1
https://escholarship.org/uc/item/35r029z1
Autor:
Andre Ghetti, Guy Page, Brian Krause, Bryce Winrow, Yannick Miron, Ky Truong, Alexa Stafford, Najah Abi Gerges
Publikováno v:
Journal of visualized experiments : JoVE. (186)
The evaluation of changes in heart contractility is essential during preclinical development for new cardiac- and non-cardiac-targeted compounds. This paper describes a protocol for assessing changes in contractility in adult human primary ventricula
Autor:
Phuong T. Nguyen, Hai M. Nguyen, Karen M. Wagner, Robert G. Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W. Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W. Pennington, Bruce Hammock, Theanne N. Griffith, Jon T. Sack, Heike Wulff, Vladimir Yarov-Yarovoy
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d947d4b583c02645779462fd248962
https://doi.org/10.1101/2022.07.21.500925
https://doi.org/10.1101/2022.07.21.500925
Publikováno v:
The Journal of Pain. 24:15