Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Andre F Palmer"'
Autor:
Chintan Savla, Andre F Palmer
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263996 (2022)
The long-term storage stability and portability of hemoglobin (Hb)-based oxygen carriers are important design criteria in the development of these therapeutics. Lyophilization or storing proteins in a freeze-dried form is known to increase storage li
Externí odkaz:
https://doaj.org/article/7d46da2eb469476d93d523ea80e94ebc
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0269939 (2022)
Particle encapsulated hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) have clear advantages over their acellular counterparts because of their larger molecular diameter and lack of vasoactivity upon transfusion. Poly(ethylene glycol) surface conju
Externí odkaz:
https://doaj.org/article/4993dcabde7d4cff9854f32ddb79fa22
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263782 (2022)
Methemoglobin (metHb) arises from the oxidation of ferrous hemoglobin (HbFe2+, Hb) to ferric hemoglobin (HbFe3+, metHb), which is unable to bind gaseous ligands such as oxygen (O2) and carbon monoxide (CO), and binds to nitric oxide (NO) significantl
Externí odkaz:
https://doaj.org/article/477676030ef64c189564ca17ed711967
Autor:
Mitchell R H Weigand, Jenifer Gómez-Pastora, James Kim, Matthew T Kurek, Richard J Hickey, David C Irwin, Paul W Buehler, Maciej Zborowski, Andre F Palmer, Jeffrey J Chalmers
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257061 (2021)
A new method for hemoglobin (Hb) deoxygenation, in suspension or within red blood cells (RBCs) is described using the commercial enzyme product, EC-Oxyrase®. The enzymatic deoxygenation method has several advantages over established deoxygenation me
Externí odkaz:
https://doaj.org/article/43431974dcc5428b83f6d54eb72192ce
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008157 (2020)
Oxygen (O2) delivery facilitated by hemoglobin (Hb)-based O2 carriers (HBOCs) is a promising strategy to increase the effectiveness of chemotherapeutics for treatment of solid tumors. However, the heterogeneous vascular structures present within tumo
Externí odkaz:
https://doaj.org/article/1a978880b8ef4f4880fbcf0c7de38cb1
Autor:
Donald A Belcher, Julia A Ju, Jin Hyen Baek, Ayla Yalamanoglu, Paul W Buehler, Daniele M Gilkes, Andre F Palmer
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191275 (2018)
A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass, which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human hemoglobin (PolyhHb) can be transfused into the systemic circulation to incre
Externí odkaz:
https://doaj.org/article/db402f0e3f0b4bf1b7da163fb38606ff
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Preclinical studies suggest that haptoglobin (Hp) supplementation could be an effective therapeutic modality during acute or chronic hemolytic diseases. Hp prevents Hb extravasation and neutralizes Hb’s oxidative and NO scavenging activity in the v
Externí odkaz:
https://doaj.org/article/46687a558cbf434ca801158e777eba34
Autor:
Cynthia R. Muller, Alexander T. Williams, Allyn M. Eaker, Cynthia Walser, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Wolfe, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116789- (2024)
The widespread adoption of high-calorie, high-fat, high-sucrose diets (HFHSD) has become a global health concern, particularly due to their association with cardiovascular diseases and metabolic disorders. These comorbidities increase susceptibility
Externí odkaz:
https://doaj.org/article/b20cb5ee5fce46bfbb87368a929784a2
Autor:
Carlos J. Munoz, Daniela Lucas, Jacinda Martinez, Mia Ricario, Quintin T. O'Boyle, Ivan S. Pires, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116569- (2024)
Alpha-alpha diaspirin-crosslinked human hemoglobin (DCLHb or ααHb) was a promising early generation red blood cell (RBC) substitute. The DCLHb was developed through a collaborative effort between the United States Army and Baxter Healthcare. The co
Externí odkaz:
https://doaj.org/article/56fb0c0c15a04929bbd507e481d79631
Publikováno v:
Biomacromolecules. 24:2022-2029
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c35e02d65e8f812a9a063ef1af6bb171
https://doi.org/10.1021/acs.biomac.2c01420
https://doi.org/10.1021/acs.biomac.2c01420