Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin–Kallikrein System in Severe COVID-19

Autor: Eli Mansour, Andre C. Palma, Raisa G. Ulaf, Luciana C. Ribeiro, Ana Flavia Bernardes, Thyago A. Nunes, Marcus V. Agrela, Bruna Bombassaro, Milena Monfort-Pires, Rafael L. Camargo, Eliana P. Araujo, Natalia S. Brunetti, Alessandro S. Farias, Antônio Luís E. Falcão, Thiago Martins Santos, Plinio Trabasso, Rachel P. Dertkigil, Sergio S. Dertkigil, Maria Luiza Moretti, Licio A. Velloso

Publikováno v: Viruses, Vol 13, Iss 2, p 309 (2021)

Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major pathological finding in autopsies explaining O2 diffusion failure and hypoxemia

Externí odkaz: https://doaj.org/article/bb37aaffc8a24fed8b49cb003d3f179f

Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19

Autor: Michael W. Henderson, Franciele Lima, Carla Roberta Peachazepi Moraes, Anton Ilich, Stephany Cares Huber, Mayck Silva Barbosa, Irene Santos, Andre C. Palma, Thyago Alves Nunes, Raisa Gusso Ulaf, Luciana Costa Ribeiro, Ana Flavia Bernardes, Bruna Bombassaro, Sergio San Juan Dertkigil, Maria Luiza Moretti, Sidney Strickland, Joyce M. Annichino-Bizzacchi, Fernanda Andrade Orsi, Eli Mansour, Licio A. Velloso, Nigel S. Key, Erich Vinicius De Paula

Publikováno v: Blood advances. 6(11)

Coagulation activation is a prominent feature of severe acute respiratory syndrome coronavirus 2 (COVID-19) infection. Activation of the contact system and intrinsic pathway has increasingly been implicated in the prothrombotic state observed in both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac3300a89b8a9ee0d8cb55eb7b65127
https://pubmed.ncbi.nlm.nih.gov/35235941

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Autor: Carlos Alberto Oliveira de Biagi Junior, Natalia S Brunetti, Robson Francisco Carvalho, André Schwambach Vieira, Victor Corasolla Carregari, Ana Campos Codo, Eli Mansour, Maria Luiza Moretti, Raisa G. Ulaf, Lais D. Coimbra, Stéfanie Primon Muraro, Licio A. Velloso, Juliana Silveira Prodonoff, Thyago A. Nunes, Lauar de Brito Monteiro, Karina Bispo dos Santos, Alexandre Borin, Guilherme Reis-de-Oliveira, André Damasio, Andrei C. Sposito, Marcus V. Agrela, Gabriela Fabiano de Souza, Fernanda Crunfli, Daniel A. Toledo-Teixeira, Helder I. Nakaya, Gustavo Gastão Davanzo, Daniel Martins-de-Souza, Pierina Lorencini Parise, Pedro M. Moraes-Vieira, Jeffersson Leandro Jimenez Restrepo, Vinícius O. Boldrini, Rafael Elias Marques, Alessandro S. Farias, João Victor Virgilio-da-Silva, Andre C. Palma, A. F. Bernardes, Fabrício Bíscaro Pereira, Helison R. Carmo, Marcelo A. Mori, Luciana C. Ribeiro, José Luiz Proença-Módena, Pedro Henrique Vendramini, Marco Aurélio Ramirez Vinolo, M. C. Martini

Publikováno v: Cell Metabolism
Signal Transduction and Targeted Therapy
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Made available in DSpace on 2020-12-12T02:25:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2143060a61e4753e054c25c25cc99d65

Elevated Glucose Levels Favor Sars-Cov-2 Infection and Monocyte Response Through a Hif-1α/Glycolysis Dependent Axis

Autor: Raisa G. Ulaf, Pedro Vieira, Pierina Lorencini Parise, Helison Rafael Pereira do Carmo, Victor Corasolla Carregari, Lais D. Coimbra, Fabricio Pereira, Helder I. Nakaya, Fernanda Crunfli, Licio A. Velloso, A. F. Bernardes, Gustavo Gastão Davanzo, Jeffersson Leandro Jimenez Restrepo, Alexandre Borin, Vinícius O. Boldrini, Daniel Martins-de-Souza, Carlos Alberto Oliveira de Biagi, José Luiz Proença Modena, André Damasio, Maria Luiza Moretti, Marcus V. Agrela, Marcelo A. Mori, Andre C. Palma, Stéfanie Primon Muraro, Lauar de Brito Monteiro, Guilherme Reis-de-Oliveira, M. C. Martini, Andrei C. Sposito, Daniel Teixeira, Natalia S Brunetti, Robson Francisco Carvalho, Thyago A. Nunes, Pedro Henrique Vendramini, Alessandro S. Farias, Karina Rodrigues Santos, Marco Aurélio Ramirez Vinolo, André Schwambach Vieira, Ana Campos Codo, Gabriela F. P. de Souza, Eli Mansour

Publikováno v: SSRN Electronic Journal.

COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c326e447820956835055567ddd1e6c1
https://doi.org/10.2139/ssrn.3606770

PERFIL CLÍNICO, EPIDEMIOLÓGICO E SOROLÓGICO DE PACIENTES COM SUSPEITA DE DOENÇA DE LYME NO HOSPITAL DE CLÍNICAS DA UNICAMP, CAMPINAS, SÃO PAULO, BRASIL

Autor: Plínio Trabasso, Mariângela Ribeiro Resende, Maria Luiza Moretti, Andre C. Palma, Rodrigo Nogueira Angerami, Amanda Tereza Ferreira, Márcia Teixeira Garcia

Publikováno v: The Brazilian Journal of Infectious Diseases. 22:132-133

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b75dbba2d35e64cdfdb42a0d773551a
https://doi.org/10.1016/j.bjid.2018.10.252