Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andre C. Carpentier"'
Autor:
Basma A. Ahmed, Frank J. Ong, Nicole G. Barra, Denis P. Blondin, Elizabeth Gunn, Stephan M. Oreskovich, Jake C. Szamosi, Saad A. Syed, Emily K. Hutchings, Norman B. Konyer, Nina P. Singh, Julian M. Yabut, Eric M. Desjardins, Fernando F. Anhê, Kevin P. Foley, Alison C. Holloway, Michael D. Noseworthy, Francois Haman, Andre C. Carpentier, Michael G. Surette, Jonathan D. Schertzer, Zubin Punthakee, Gregory R. Steinberg, Katherine M. Morrison
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 9, Pp 100397- (2021)
Summary: In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and
Externí odkaz:
https://doaj.org/article/3f605dad37834d20b7e3330887e81098
Autor:
Lauralyne Dumont, Alexandre Caron, Gabriel Richard, Etienne Croteau, Melanie Fortin, Frederique Frisch, Serge Phoenix, Stephanie Dubreuil, Brigitte Guerin, Eric E. Turcotte, Andre C. Carpentier, Denis P. Blondin
Pharmacological stimulation of human brown adipose tissue (BAT) has been hindered by either ineffective activation or undesirable off-target secondary effects. Oral administration of the maximal allowable dose of mirabegron (200 mg), a β3-adrenergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76dde99ae96231cff7eb2715e578e954
https://doi.org/10.1101/2023.03.22.23287600
https://doi.org/10.1101/2023.03.22.23287600
Autor:
Katherine M. Morrison, Gregory R. Steinberg, Zubin Punthakee, Andre C. Carpentier, Francois Haman, Michael D. Noseworthy, Nina P. Singh, Norman B. Konyer, Elizabeth Gunn, Denis P. Blondin, Frank J. Ong, Nina Varah, Basma A. Ahmed
Childhood obesity is a growing worldwide problem. In adults, lower cold-induced brown adipose tissue (BAT) activity is linked to obesity and metabolic dysfunction; this relationship remains uncertain in children. In this cross-sectional study, we com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33782d4440ee65bdb8005f3dc8a5716
https://doi.org/10.2337/figshare.19324106
https://doi.org/10.2337/figshare.19324106
Autor:
Valérie St-Pierre, Gabriel Richard, Etienne Croteau, Mélanie Fortier, Camille Vandenberghe, André C. Carpentier, Bernard Cuenoud, Stephen C. Cunnane
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
The heart and kidney have a high energy requirement, but relatively little is known about their utilization of ketones as a potential energy source. We assessed the metabolism of the ketone tracer, carbon-11 acetoacetate (11C-AcAc), by the left and r
Externí odkaz:
https://doaj.org/article/f8b52fc572c441c1b29cacc75a4e84fc
Autor:
Run Zhou Ye, Emilie Montastier, Frédérique Frisch, Christophe Noll, Hugues Allard-Chamard, Nicolas Gévry, André Tchernof, André C. Carpentier
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108692- (2024)
Summary: Adipocyte hypertrophy is associated with metabolic complications independent of obesity. We aimed to determine: 1) the association between adipocyte size and postprandial fatty acid metabolism; 2) the potential mechanisms driving the obesity
Externí odkaz:
https://doaj.org/article/679ccead7b3043cbb1c81f76245c3683
Autor:
Gregory R. Steinberg, Andre C. Carpentier, Tahniyah Haq, Frank J. Ong, François Haman, Katherine M. Morrison, Basma A. Ahmed, Stephan Oreskovich, Norman B. Konyer, Michael D. Noseworthy, Denis P. Blondin
Publikováno v:
Clinical science (London, England : 1979). 132(10)
The activation of brown adipose tissue (BAT) is associated with reductions in circulating lipids and glucose in rodents and contributes to energy expenditure in humans indicating the potential therapeutic importance of targetting this tissue for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f31e7e4d3aa1dbb3d33a59d59fe8f2
https://pubmed.ncbi.nlm.nih.gov/29802209
https://pubmed.ncbi.nlm.nih.gov/29802209
Autor:
Bernard Cuenoud, Etienne Croteau, Valérie St-Pierre, Gabriel Richard, Mélanie Fortier, Camille Vandenberghe, André C. Carpentier, Stephen C. Cunnane
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Ketones are alternative energy substrates for the heart and kidney but no studies have investigated their metabolism simultaneously in both organs in humans. The present double tracer positron emission tomography (PET) study evaluated the organ distr
Externí odkaz:
https://doaj.org/article/7f946f45654446788263a0bed1e207bf
Autor:
Run Zhou Ye, Christophe Noll, Gabriel Richard, Martin Lepage, Éric E. Turcotte, André C. Carpentier
Publikováno v:
SLAS Technology, Vol 27, Iss 1, Pp 76-84 (2022)
The advent of deep-learning has set new standards in an array of image translation applications. At present, the use of these methods often requires computer programming experience. Non-commercial programs with graphical interface usually do not allo
Externí odkaz:
https://doaj.org/article/4024083413b74372b49c128f26c2cd74
Autor:
Romain Girard, Sarah Tremblay, Christophe Noll, Stéphanie St-Jean, Christine Jones, Yves Gélinas, Faïza Maloum-Rami, Nathalie Perreault, Mathieu Laplante, André C. Carpentier, François Boudreau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
HNF4A is a nuclear receptor that regulates liver lipid homeostasis. Here the authors show that HNF4A is not required for intestinal lipid metabolism but controls energy expenditure under diet induced obesity through the fat-induced release of glucose
Externí odkaz:
https://doaj.org/article/2491c26a297548a99a16cda717651be3
Autor:
Thomas Grenier-Larouche, Lydia Coulter Kwee, Yann Deleye, Paola Leon-Mimila, Jacquelyn M. Walejko, Robert W. McGarrah, Simon Marceau, Sylvain Trahan, Christine Racine, André C. Carpentier, Aldons J. Lusis, Olga Ilkayeva, Marie-Claude Vohl, Adriana Huertas-Vazquez, André Tchernof, Svati H. Shah, Christopher B. Newgard, Phillip J. White
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Hepatic de novo lipogenesis is influenced by the branched-chain α-keto acid dehydrogenase (BCKDH) kinase (BCKDK). Here, we aimed to determine whether circulating levels of the immediate substrates of BCKDH, the branched-chain α-keto acids (BCKAs),
Externí odkaz:
https://doaj.org/article/6137ea5ab08f4f1cb6e623ab02150e6f