Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Andre Bernat"'
Publikováno v:
Thrombosis and Haemostasis. 87:238-244
SummaryThe effect of new heparin mimetics (synthetic oligosaccharides) was studied in vitro with regard to thrombin generation (TG) in rat platelet rich plasma (PRP) and whole blood (WB) and in vivo on stasis-induced venous thrombosis in the rat.TG i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c78dcf7af191ee76170cf9f16cc22731
https://doi.org/10.1055/s-0037-1612979
https://doi.org/10.1055/s-0037-1612979
Autor:
Françoise Bono, Petitou Maurice, F. Roye, Andre Bernat, J. P. Hérault, J. M. Herbert, C. Michaux, Paul J. Schaeffer
Publikováno v:
Thrombosis and Haemostasis. 87:985-989
SummaryPharmacokinetics of oligosaccharides displaying various affinities for antithrombin (AT) allowed us to show that there was a close relationship between the plasma half-life of these antithrombotic oligosaccharides and their affinity for AT. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34ddbe29b4a6d70a955f662b83eb588
https://doi.org/10.1055/s-0037-1613122
https://doi.org/10.1055/s-0037-1613122
Autor:
P. Duchaussoy, J. M. Herbert, Paul J. Schaeffer, Pierre Savi, J. P. Hérault, Andre Bernat, Petitou Maurice, Pierre-Alexandre Driguez
Publikováno v:
Thrombosis and Haemostasis. 85:852-860
SummarySR123781A, a synthetic hexadecasaccharide comprising an anti-thrombin (AT) binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained from glucose through a convergent synthesis. SR123781A showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd830edfb9f4709062548fa04886ce66
https://doi.org/10.1055/s-0037-1615759
https://doi.org/10.1055/s-0037-1615759
Publikováno v:
Platelets. 11:43-48
Since results of recent clinical trial, performed in patients suffering from acute coronary syndromes, suggested that aspirin improved the efficacy of an anti-GP-IIb/IIIa therapy, this work was set to study the mechanism underlying such a mechanism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8786b121e115ed6c8069640c7b773e56
https://doi.org/10.1080/09537100075797
https://doi.org/10.1080/09537100075797
Autor:
B. Perrin, C. Jongbloet, Jean-Pascal Herault, Andre Bernat, Jean-Marc Herbert, A. M. Pflieger
Publikováno v:
Thrombosis and Haemostasis. 84:668-674
SummaryThe aim of this study was to investigate the effect of factor Xa inhibitors on the prothrombinase activity of platelet-derived microparticles in vitro and in vivo. The factor Xa inhibitors studied were DX9065A (a direct factor Xa inhibitor) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e974a3ca268756964bbb497de3ae3a6d
https://doi.org/10.1055/s-0037-1614085
https://doi.org/10.1055/s-0037-1614085
Autor:
A. Volk, C. Roque, Jean-Marc Herbert, M. Sainte Marie, P. Meric, Peter R. Hoffmann, Andre Bernat, O. Fedel
Publikováno v:
Fibrinolysis and Proteolysis. 13:193-201
The main disadvantage of current thromboembolic stroke models is non-uniformity of location and size of the infarcts. In the present study, standard-sized autologous macroclots were formed by means of polyethylene tubings with defined inner diameters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07ad8f5dc347a005b0b85b4112797313
https://doi.org/10.1016/s0268-9499(99)90071-1
https://doi.org/10.1016/s0268-9499(99)90071-1
Autor:
Maurice Petitou, Jean-Marc Herbert, Andre Bernat, Philippe Duchaussoy, Jean-Claude Lormeau, Jean-Pascal Herault, Pierre-Alexandre Driguez
Publikováno v:
Nature. 398:417-422
Unwanted side effects of pharmacologically active compounds can usually be eliminated by structural modifications. But the complex heterogeneous structure of the polysaccharide heparin1 has limited this approach to fragmentation, leading to slightly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4886440427cfc8da0a23fbac4c674b
https://doi.org/10.1038/18877
https://doi.org/10.1038/18877
Publikováno v:
Thrombosis and Haemostasis. 81:957-960
SummaryClopidogrel (25 mg/kg, p.o.), a potent and selective inhibitor of ADP-induced platelet aggregation, significantly inhibited, in the presence of platelets, ex vivo thrombin generation triggered by low concentrations of tissue factor. Clopidogre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf5f937e0e4e0610cd70e6dd808add25
https://doi.org/10.1055/s-0037-1614606
https://doi.org/10.1055/s-0037-1614606
Publikováno v:
Thrombosis and Haemostasis. 80:512-518
SummaryIt is unknown whether the addition of aspirin might increase both the efficacy and the potency of clopidogrel, a potent and selective ADP blocker. For that purpose, the efficacy of clopidogrel (1–20 mg/kg, p.o.) administered orally to rabbit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738dfdbd590bbc74fb000c6c02641a41
https://doi.org/10.1055/s-0037-1615238
https://doi.org/10.1055/s-0037-1615238
Autor:
Jean-Marc Herbert, Maurice Petitou, Marie-Francoise Bordes, Alain Badorc, Jean-Pierre Maffrand, Lalé A, de Cointet P, Andre Bernat, Pierre Savi
Publikováno v:
Journal of Medicinal Chemistry. 40:3393-3401
The platelet fibrinogen receptor GpIIb-IIIa is curently considered a target of choice for drugs used in the prevention and treatment of thrombosis. Ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl)imino]met...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04845bef979001a03632e1287bff817d
https://doi.org/10.1021/jm970240y
https://doi.org/10.1021/jm970240y