Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Andre Levchenko"'
Publikováno v:
eLife, Vol 12 (2024)
Angiogenesis is a morphogenic process resulting in the formation of new blood vessels from pre-existing ones, usually in hypoxic micro-environments. The initial steps of angiogenesis depend on robust differentiation of oligopotent endothelial cells i
Externí odkaz:
https://doaj.org/article/dc2a6080020640a4bc2f7473d8af19b8
Autor:
Anasuya Dighe, Jamie Maziarz, Arig Ibrahim-Hashim, Robert A. Gatenby, Kshitiz, Andre Levchenko, Günter P. Wagner
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108593- (2024)
Summary: Gene expression change is a dominant mode of evolution. Mutations, however, can affect gene expression in multiple cell types. Therefore, gene expression evolution in one cell type can lead to similar gene expression changes in another cell
Externí odkaz:
https://doaj.org/article/448ca9ed8de64c84a2076097d1c4a2ff
Autor:
Vanessa M. Scanlon, Evrett N. Thompson, Betty R. Lawton, Maria Kochugaeva, Kevinminh Ta, Madeline Y. Mayday, Juliana Xavier-Ferrucio, Elaine Kang, Nicole M. Eskow, Yi-Chien Lu, Nayoung Kwon, Anisha Laumas, Matthew Cenci, Kalyani Lawrence, Katie Barden, Shannon T. Larsuel, Fiona E. Reed, Gabriela Peña-Carmona, Ashley Ubbelohde, June P. Lee, Shakthi Boobalan, Yvette Oppong, Rachel Anderson, Colby Maynard, Kaylie Sahirul, Callista Lajeune, Varsha Ivathraya, Tiffany Addy, Patricia Sanchez, Colin Holbrook, Andrew Tri Van Ho, James S. Duncan, Helen M. Blau, Andre Levchenko, Diane S. Krause
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Single-cell assays have enriched our understanding of hematopoiesis and, more generally, stem and progenitor cell biology. However, these single-end-point approaches provide only a static snapshot of the state of a cell. To observe and measu
Externí odkaz:
https://doaj.org/article/76d92c4dbeae436dbee982f2d2787526
Publikováno v:
Biology, Vol 12, Iss 12, p 1461 (2023)
A cell constantly receives signals and takes different fates accordingly. Given the uncertainty rendered by signal transduction noise, a cell may incorrectly perceive these signals. It may mistakenly behave as if there is a signal, although there is
Externí odkaz:
https://doaj.org/article/b693e960d1d74846a63db9c0e8bf1306
Autor:
Allison Marie Greaney, Micha Sam Brickman Raredon, Maria P. Kochugaeva, Laura E. Niklason, Andre Levchenko
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106175- (2023)
Summary: Despite much concerted effort to better understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection, relatively little is known about the dynamics of early viral entry and infection in the airway. Here we analyzed
Externí odkaz:
https://doaj.org/article/e76d935e39d34605bd7248a4a67b9e0f
Autor:
Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curley, Ben Cappiello, Jens C. Schwamborn, Eric J. Hill, Paul Roach, Daniel Tornero, Caroline Krall, Rheinallt Parri, Fenna Sillé, Andre Levchenko, Rabih E. Jabbour, Brett J. Kagan, Cynthia A. Berlinicke, Qi Huang, Alexandra Maertens, Kathrin Herrmann, Katya Tsaioun, Raha Dastgheyb, Christa Whelan Habela, Joshua T. Vogelstein, Thomas Hartung
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of powe
Externí odkaz:
https://doaj.org/article/aebc0f0cd878418ebed9205a612b1932
Autor:
Micha Sam Brickman Raredon, Junchen Yang, James Garritano, Meng Wang, Dan Kushnir, Jonas Christian Schupp, Taylor S. Adams, Allison M. Greaney, Katherine L. Leiby, Naftali Kaminski, Yuval Kluger, Andre Levchenko, Laura E. Niklason
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell–cell and ligand–receptor connectivity that influence the function of tissues and organs. However, the quantification and visualization o
Externí odkaz:
https://doaj.org/article/667f51d390964320809ccc3bfb1c4a68
Publikováno v:
eLife, Vol 11 (2022)
Kinase activity in signaling networks frequently depends on regulatory subunits that can both inhibit activity by interacting with the catalytic subunits and target the kinase to distinct molecular partners and subcellular compartments. Here, using a
Externí odkaz:
https://doaj.org/article/840b43bd8f614d8cbf3330e83b302ad3
Autor:
Lin, Benjamin, Holmes, William R., Wang, ChiaoChun, Ueno, Tasuku, Harwell, Andrew, Edelstein-Keshet, Leah, Inoue, Takanari, and, Andre Levchenko
Migrating cells possess intracellular gradients of Rho GTPases, but it is unknown whether these shallow gradients themselves can induce motility. Here we describe a new method to present cells with induced linear gradients of active, endogenous Rac w
Externí odkaz:
http://arxiv.org/abs/1204.5517
Autor:
JinSeok Park, Deok-Ho Kim, Sagar R. Shah, Hong-Nam Kim, Kshitiz, Peter Kim, Alfredo Quiñones-Hinojosa, Andre Levchenko
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Reorganisation of the extracellular matrix (ECM) controls processes involving epithelial-mesenchymal transition (EMT). Here, the authors show that EMT occurring in epithelial cells on a fabricated nano-engineered cell adhesion surface is triggered by
Externí odkaz:
https://doaj.org/article/fab1f839a32141ee848340f076fa446a