Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andre, Shavnya"'
Autor:
David F. Fernández, María González-Esguevillas, Sebastian Keess, Felix Schäfer, Jens Mohr, Andre Shavnya, Thomas Knauber, David C. Blakemore, David W. C. MacMillan
Publikováno v:
Organic Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f6127ac197479b4daafb0cab424c708
https://doi.org/10.1021/acs.orglett.3c00994
https://doi.org/10.1021/acs.orglett.3c00994
Autor:
Ian B. Moses, Neal W. Sach, Loïc R E Pantaine, Andre Shavnya, David C. Blakemore, Xinlan A F Cook, Michael C. Willis
Publikováno v:
Angewandte Chemie (International Ed. in English)
Heteroaromatic sulfinates are effective nucleophilic reagents in Pd0‐catalyzed cross‐coupling reactions with aryl halides. However, metal sulfinate salts can be challenging to purify, solubilize in reaction media, and are not tolerant to multi‐
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926f4bf73e208897e440065cbc4d1190
http://europepmc.org/articles/PMC8518705
http://europepmc.org/articles/PMC8518705
Autor:
Shawn D. Doran, Jana Polivkova, James A. Southers, Scott W. Bagley, Kim Huard, Dilinie P. Fernando, Manthena V.S. Varma, David A. Beebe, David J. Edmonds, Robert L. Dow, Benjamin A. Thuma, Collin Crowley, William P. Esler, Trenton T. Ross, David A. Tess, Mark Niosi, Amit S. Kalgutkar, Jeffrey A. Pfefferkorn, Norimitsu Shirai, David A. Griffith, Shawn Cabral, Andrew H. Smith, Gregg D. Cappon, Vincent Mascitti, Matthew S. Dowling, Andre Shavnya, David Price, Ayman El-Kattan, Aaron C. Smith, Yi-an Bi, Spiros Liras, Xiaojing Helen Yang, Cathy Préville
Publikováno v:
Journal of Medicinal Chemistry. 63:10879-10896
Preclinical and clinical data suggest that acetyl-CoA carboxylase (ACC) inhibitors have the potential to rebalance disordered lipid metabolism, leading to improvements in nonalcoholic steatohepatitis (NASH). Consistent with these observations, first-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07da4330450bd15b2bafcbaadc0cc94b
https://doi.org/10.1021/acs.jmedchem.0c00640
https://doi.org/10.1021/acs.jmedchem.0c00640
Autor:
Janette McKnight, Andre Shavnya, Neal W. Sach, David C. Blakemore, Ian B. Moses, Michael C. Willis
An efficient Pd-catalyzed one-pot desulfinative cross-coupling to access medicinally relevant di(hetero)arylmethanes is reported. The method is reductant-free, and involves a sulfinate transfer reagent and a Pd-catalyst mediating the union of two ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e95feaf513ca29b2860e3f04451000
https://ora.ox.ac.uk/objects/uuid:5b1f7d51-3f8e-4d6d-8a88-c2c898529e93
https://ora.ox.ac.uk/objects/uuid:5b1f7d51-3f8e-4d6d-8a88-c2c898529e93
Autor:
Kathleen A. Farley, Parag Sahasrabudhe, Manjinder S. Lall, Justin Bellenger, Bruce Allen Lefker, Xidong Feng, Timothy L. Foley, Scott L. Hultgren, Dominik K. Kölmel, Jinqiao Wan, Bo Liu, Justin I. Montgomery, Anokha S. Ratnayake, Mark Edward Flanagan, Shi Chen, Laura J. Byrnes, Andre Shavnya, Tim F. Ryder
Publikováno v:
Bioorganicmedicinal chemistry. 41
The ability to predict chemical structure from DNA sequence has to date been a necessary cornerstone of DNA-encoded library technology. DNA-encoded libraries (DELs) are typically screened by immobilized affinity selection and enriched library members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb276460d12574fb80ff34a159c182eb
https://pubmed.ncbi.nlm.nih.gov/34000509
https://pubmed.ncbi.nlm.nih.gov/34000509
Autor:
Gang Xing, David Price, Aaron C. Smith, Jayasankar Jasti, Kentaro Futatsugi, Steven B. Coffey, Meihua Tu, Kevin D. Parris, Yan Weng, Dilinie P. Fernando, Kay Ahn, Matthew S. Dowling, Kim Huard, Jayvardhan Pandit, Jeffrey A. Pfefferkorn, Benjamin A. Thuma, Brian Raymer, Tim F. Ryder, Gregory J. Tesz, Andre Shavnya, Amit S. Kalgutkar, Jun Zhou, Hanna M. Wisniewska, Jemy A. Gutierrez, John D. Knafels, Magee Thomas Victor, Ingrid A. Stock, Sylvie Perez, Tsai Andy
Publikováno v:
Journal of medicinal chemistry. 63(22)
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to fruct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c107a413095d612ee94dff2632747e3a
https://pubmed.ncbi.nlm.nih.gov/32910646
https://pubmed.ncbi.nlm.nih.gov/32910646
Autor:
Daniel W. Widlicka, Nathan E. Genung, Jana Polivkova, Daniel W. Kung, Wiglesworth Kristin, Thomas Andrew Brandt, Jun Xiao, Matthew S. Dowling, Yingxin Zhang, Paul M. Herrinton, David J. Edmonds, Todd Zahn, Ka Ning Yip, Colin R. Rose, Qifang Li, Jane Panteleev, Shawn Cabral, Andre Shavnya, Nandell F. Keene, John D. Weaver, Benjamin A. Thuma, Michael Herr, Ian Edmonds, Gary Erik Aspnes, Guoqiang Wang, Philip D. Dent, Dilinie P. Fernando, Aaron C. Smith, Michael G. Vetelino, Sophie Y. Lavergne, Edward L. Conn
Publikováno v:
Organic Process Research & Development. 22:681-696
Indole acids 1, 2, and 3 are potent 5′-adenosine monophosphate-activated protein kinase (AMPK) activators for the potential treatment of diabetic nephropathy. Compounds 1–3 were scaled to supply material for preclinical studies, and indole 3 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b628a560af69b1edadd146b3a36513be
https://doi.org/10.1021/acs.oprd.8b00059
https://doi.org/10.1021/acs.oprd.8b00059
Autor:
Samit Kumar Bhattacharya, Aaron C. Smith, Paula M. Loria, Kevin J. Filipski, Kun Song, Edward L. Conn, Yan Weng, Markus Boehm, Matthew F. Sammons, Harald Jüppner, Andre Shavnya, Jane Panteleev, Janice A. Brown, Valerie Clerin, Carie Facemire
Publikováno v:
ACS Medicinal Chemistry Letters. 9:440-445
[Image: see text] Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Inhibition of NaPi2a may enhance urinary phosphate exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a7ba40a64728c0cdcaf8576635f630
https://doi.org/10.1021/acsmedchemlett.8b00013
https://doi.org/10.1021/acsmedchemlett.8b00013
Publikováno v:
Advanced Synthesis & Catalysis. 360:1768-1774
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::807ca0dfc1b50d6f5c60daab69e1c852
https://doi.org/10.1002/adsc.201800071
https://doi.org/10.1002/adsc.201800071
Autor:
John D. Knafels, David Price, Matthew Gorgoglione, Aaron C. Smith, Kevin D. Parris, Jemy A. Gutierrez, Magee Thomas Victor, Erik Alphie Lachapelle, Yan Weng, Edward L. Conn, Jeffrey A. Pfefferkorn, Jane M. Withka, Kim Huard, Matthew S. Dowling, Timothy A. Subashi, Trenton T. Ross, Benjamin A. Thuma, Kris A. Borzilleri, Paul A. Amor, Jeffrey S. Culp, Meihua Tu, Sylvie Perez, Jayvardhan Pandit, Andre Shavnya, Boris A. Chrunyk, Gang Xing, John D. Weaver, Yang Cong, Kay Ahn, David A. Beebe, Brian Raymer, Gregory J. Tesz, Steven B. Coffey
Publikováno v:
Journal of Medicinal Chemistry. 60:7835-7849
Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b654213309542f5b2a14a9d23ebc4df8
https://doi.org/10.1021/acs.jmedchem.7b00947
https://doi.org/10.1021/acs.jmedchem.7b00947