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Autor:
Damiën van Berlo, Marjolijn Woutersen, Andre Muller, Marja Pronk, Jelle Vriend, Betty Hakkert
Publikováno v:
Regulatory Toxicology and Pharmacology. 139:105366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e72211f7a011c11f18f3934d640936
https://doi.org/10.1016/j.yrtph.2023.105366
https://doi.org/10.1016/j.yrtph.2023.105366
Autor:
de Mello Junior, Wilson Alves, Arruda, Luciano Rodrigo Peres, Coluccini, André Muller, da Silva Nunes, Rodrigo Pereira, Pedro, Márcio do Amaral Camargo, de Souza, Márcio Regis, Zabeu, José Luis Amin
Publikováno v:
In Revista Brasileira de Ortopedia (English Edition) January 2011 46(1):64-68
Autor:
Minne B. Heringa, Betty C. Hakkert, Marja E.J. Pronk, Nicole H.P. Cnubben, Andre Muller, Wout Slob, Marjolijn Woutersen
The KMD (kinetically-derived maximum dose) is an increasingly advocated concept that uses toxicokinetic data in the top dose selection for toxicity testing. Application of this concept may have serious regulatory implications though, especially in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21eb0dd1c55dfd4532f1e2cc54198c59
http://hdl.handle.net/10029/624063
http://hdl.handle.net/10029/624063
Autor:
Marjolijn Woutersen, Joop A. de Knecht, Betty C. Hakkert, Martijn Beekman, Andre Muller, Marja E.J. Pronk
Publikováno v:
Human and Ecological Risk Assessment: An International Journal. 25:1996-2016
The REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) data requirements for mutagenicity and carcinogenicity have been compared to the criteria for classification under C...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63a376a6c88ad14603a787fb6fc4e9bc
https://doi.org/10.1080/10807039.2018.1480351
https://doi.org/10.1080/10807039.2018.1480351
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 114
In the EU, one of the key determinants in the regulation and management of substances to ensure adequate protection of human health is the outcome of toxicity studies. These studies should therefore be performed in a way that the data generated are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39b12444ad9f7cc82863829e7093560
https://pubmed.ncbi.nlm.nih.gov/32679052
https://pubmed.ncbi.nlm.nih.gov/32679052
Autor:
Betty C. Hakkert, Nicole H.P. Cnubben, Minne B. Heringa, Wout Slob, Marjolijn Woutersen, Andre Muller, Marja E.J. Pronk
Publikováno v:
Regulatory Toxicology and Pharmacology. 116:104730
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f96ef3af92c7eb1396df928d6d2e62
https://doi.org/10.1016/j.yrtph.2020.104730
https://doi.org/10.1016/j.yrtph.2020.104730
Autor:
Andre Muller
Es ist nie zu spät, sich die Einstellung anzueignen und die Methoden anzuwenden, die zum Erfolg führen. Jeder, ob jung oder alt, unabhängig vom Alter, hat die Mittel und die Möglichkeit, erfolgreich zu sein oder Misserfolge zu überwinden. Ein Vo
Autor:
J J Andre Muller, Janine Ezendam, Emiel Rorije, Jan van Benthem, Aldert H. Piersma, Mirjam Luijten, Leo T.M. van der Ven
Publikováno v:
Critical Reviews in Toxicology. 44:876-894
Regulatory toxicology urgently needs applicable alternative test systems that reduce animal use, testing time, and cost. European regulation on cosmetic ingredients has already banned animal experimentation for hazard identification, and public aware
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b9863026c36357d26cc710c9a18219
https://doi.org/10.3109/10408444.2014.940445
https://doi.org/10.3109/10408444.2014.940445