Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andras Zeke"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011902 (2024)
The pathogenic, tropical Leishmania flagellates belong to an early-branching eukaryotic lineage (Kinetoplastida) with several unique features. Unfortunately, they are poorly understood from a molecular biology perspective, making development of mecha
Externí odkaz:
https://doaj.org/article/9155bae44974425ab77dca8e60930ba9
Autor:
Gergo Gogl, Boglarka Zambo, Camille Kostmann, Alexandra Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Negroni, Pascal Eberling, Pau Jané, Yves Nominé, Andras Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
Externí odkaz:
https://doaj.org/article/dff796c0f95b474fb39f559dd5885404
Autor:
Gergo Gogl, Boglarka Zambo, Camille Kostmann, Alexandra Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Negroni, Pascal Eberling, Pau Jané, Yves Nominé, Andras Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Protein networks have been widely explored but most binding affinities remain unknown, limiting the quantitative interpretation of interactomes. Here the authors measure affinities of 65,000 interactions involving human PDZ domains and target sequenc
Externí odkaz:
https://doaj.org/article/2abf01b5330741a686c599e55cea0dee
Autor:
Gergely Rona, Domenico Roberti, Yandong Yin, Julia K Pagan, Harrison Homer, Elizabeth Sassani, Andras Zeke, Luca Busino, Eli Rothenberg, Michele Pagano
Publikováno v:
eLife, Vol 7 (2018)
The mammalian FBXL10-RNF68-RNF2 ubiquitin ligase complex (FRRUC) mono-ubiquitylates H2A at Lys119 to repress transcription in unstressed cells. We found that the FRRUC is rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELE
Externí odkaz:
https://doaj.org/article/3803e7bc369145b48f3da7f6f1d9bcc1
Autor:
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this en
Externí odkaz:
https://doaj.org/article/f6d3c3032ebe40f894a83f92cc0e664c
Autor:
Klára Kirsch, András Zeke, Orsolya Tőke, Péter Sok, Ashish Sethi, Anna Sebő, Ganesan Senthil Kumar, Péter Egri, Ádám L. Póti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Reményi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphor
Externí odkaz:
https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a6
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 381 (2021)
Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation. IDRs are increasingly recognized as critical elements of regulatory networks and have been also a
Externí odkaz:
https://doaj.org/article/cf6063ae62914c77a4380e75ba280477
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1115 (2020)
Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival, or apoptosis. Mutations often accumulate in hot-spots regions, highlighting critic
Externí odkaz:
https://doaj.org/article/a800e83f2a8f4e39bce9c5042e7a7885
Autor:
András Zeke, Tomas Bastys, Anita Alexa, Ágnes Garai, Bálint Mészáros, Klára Kirsch, Zsuzsanna Dosztányi, Olga V Kalinina, Attila Reményi
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 11, Pp 1-21 (2015)
Abstract Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood. Systematic discovery of MAPK netw
Externí odkaz:
https://doaj.org/article/0d3a80ceb73f45898e010580f6b898aa