Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Andras T. Meszaros"'
Autor:
Julia Hofmann, Alexander Kofler, Melanie Schartner, Madita L. Buch, Martin Hermann, Bettina Zelger, Dietmar Öfner, Rupert Oberhuber, Theresa Hautz, Stefan Schneeberger, Andras T. Meszaros
Publikováno v:
Transplant International, Vol 37 (2024)
Organ quality can be assessed prior to transplantation, during normothermic machine perfusion (NMP) of the liver. Evaluation of mitochondrial function by high-resolution respirometry (HRR) may serve as a viability assessment concept in this setting.
Externí odkaz:
https://doaj.org/article/887bb2486fd3475688be16b8f09f2135
Autor:
Andras T. Meszaros, Annemarie Weissenbacher, Melanie Schartner, Tim Egelseer-Bruendl, Martin Hermann, Jasmin Unterweger, Christa Mittelberger, Beatrix A. Reyer, Julia Hofmann, Bettina G. Zelger, Theresa Hautz, Thomas Resch, Christian Margreiter, Manuel Maglione, Timea Komlódi, Hanno Ulmer, Benno Cardini, Jakob Troppmair, Dietmar Öfner, Erich Gnaiger, Stefan Schneeberger, Rupert Oberhuber
Publikováno v:
Transplant International, Vol 37 (2024)
Donor organ biomarkers with sufficient predictive value in liver transplantation (LT) are lacking. We herein evaluate liver viability and mitochondrial bioenergetics for their predictive capacity towards the outcome in LT. We enrolled 43 consecutive
Externí odkaz:
https://doaj.org/article/0fa1744622fe42b993bcf6d4d4930586
Autor:
Andras T. Meszaros, Julia Hofmann, Madita L. Buch, Benno Cardini, Theresia Dunzendorfer-Matt, Florian Nardin, Michael J. Blumer, Margot Fodor, Martin Hermann, Bettina Zelger, Giorgi Otarashvili, Melanie Schartner, Annemarie Weissenbacher, Rupert Oberhuber, Thomas Resch, Jakob Troppmair, Dietmar ..fner, Heinz Zoller, Herbert Tilg, Erich Gnaiger, Theresa Hautz, Stefan Schneeberger
Publikováno v:
EBioMedicine, Vol 85, Iss , Pp 104311- (2022)
Summary: Background: Reliable biomarkers for organ quality assessment during normothermic machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by oxidative phosphorylation plays a crucial role in the bioenergetic homeostasis o
Externí odkaz:
https://doaj.org/article/e529ae879efe4ad79d300a1b0ac02665
Autor:
Julia Hofmann, Andras T. Meszaros, Madita L. Buch, Florian Nardin, Verena Hackl, Carola J. Strolz, Bettina Zelger, Margot Fodor, Benno Cardini, Rupert Oberhuber, Thomas Resch, Annemarie Weissenbacher, Jakob Troppmair, Stefan Schneeberger, Theresa Hautz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9536 (2023)
The majority of organs used for liver transplantation come from brain-dead donors (DBD). In order to overcome the organ shortage, increasingly donation after circulatory death (DCD) organs are also considered. Since normothermic machine perfusion (NM
Externí odkaz:
https://doaj.org/article/d30526cf21bd4e32a3e3286c4e2ab235
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 794 (2023)
Mitochondrial ROS (mitoROS) control many reactions in cells. Biological effects of mitoROS in vivo can be investigated by modulation via mitochondria-targeted antioxidants (mtAOX, mitoTEMPO). The aim of this study was to determine how mitoROS influen
Externí odkaz:
https://doaj.org/article/1d3e90093f834a52b5670e5a012137a3
Novel, Innovative Models to Study Ischemia/Reperfusion-Related Redox Damage in Organ Transplantation
Autor:
Julia Hofmann, Marlene Pühringer, Sabrina Steinkellner, Aline-Sophie Holl, Andras T. Meszaros, Stefan Schneeberger, Jakob Troppmair, Theresa Hautz
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 31 (2022)
The implementation of ex vivo organ machine perfusion (MP) into clinical routine undoubtedly helped to increase the donor pool. It enables not just organ assessment, but potentially regeneration and treatment of marginal organs in the future. During
Externí odkaz:
https://doaj.org/article/79ac523de8e745a49113b840b2af5604
Autor:
Adelheid Weidinger, Linda Birgisdóttir, Julia Schäffer, Andras T. Meszaros, Sergejs Zavadskis, Andrea Müllebner, Matthias Hecker, Johanna Catharina Duvigneau, Natascha Sommer, Andrey V. Kozlov
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 323 (2022)
Mitochondria-targeted antioxidants (mtAOX) are a promising treatment strategy against reactive oxygen species-induced damage. Reports about harmful effects of mtAOX lead to the question of whether these could be caused by the carrier molecule triphen
Externí odkaz:
https://doaj.org/article/69f84fc0ed604dc1963ab17d99c15822
Autor:
Julia Hofmann, Verena Hackl, Hannah Esser, Andras T. Meszaros, Margot Fodor, Dietmar Öfner, Jakob Troppmair, Stefan Schneeberger, Theresa Hautz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10276 (2021)
The liver, in combination with a functional biliary system, is responsible for maintaining a great number of vital body functions. However, acute and chronic liver diseases may lead to irreversible liver damage and, ultimately, liver failure. At the
Externí odkaz:
https://doaj.org/article/65f8705e923e49e39306792c710bc61f
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 170-181 (2017)
Liver failure induced by systemic inflammatory response (SIRS) is often associated with mitochondrial dysfunction but the mechanism linking SIRS and mitochondria-mediated liver failure is still a matter of discussion. Current hypotheses suggest that
Externí odkaz:
https://doaj.org/article/1085360704a14654a6d50568c369d85c
Autor:
Ana Carolina B. Sant’Anna-Silva, Juan A. Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T. Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker
Publikováno v:
Cancers, Vol 13, Iss 7, p 1727 (2021)
Tumor cells display metabolic alterations when compared to non-transformed cells. These characteristics are crucial for tumor development, maintenance and survival providing energy supplies and molecular precursors. Anaplerosis is the property of rep
Externí odkaz:
https://doaj.org/article/eea8eea83dc246d99e0d10e52a561e34