Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Andras Bilkei-Gorzo"'
Autor:
Alessandra Gargano, Bolanle Fatimat Olabiyi, Michela Palmisano, Andreas Zimmer, Andras Bilkei-Gorzo
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionAging is associated with a decline in cognitive abilities, including memory and attention. It is generally accepted that age-related histological changes such as increased neuroinflammatory glial activity and a reduction in the number of
Externí odkaz:
https://doaj.org/article/3129527f49f449b5adef632c098a64e7
Autor:
Joanna Agnieszka Komorowska-Müller, Anne-Kathrin Gellner, Kishore Aravind Ravichandran, Andras Bilkei-Gorzo, Andreas Zimmer, Valentin Stein
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine dynamics. Previously, we have shown that a low dose chronic THC treatment improves learning abilities in old whe
Externí odkaz:
https://doaj.org/article/22fcb1d9e625465382958a5be3aff3ab
Autor:
Lena-Louise Schuele, Britta Schuermann, Andras Bilkei-Gorzo, Sara Gorgzadeh, Andreas Zimmer, Este Leidmaa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The endocannabinoid system modulates adult hippocampal neurogenesis by promoting the proliferation and survival of neural stem and progenitor cells (NSPCs). This is demonstrated by the disruption of adult neurogenesis under two experimental
Externí odkaz:
https://doaj.org/article/00785b4c972240a1ad3a3a25127f813c
Autor:
Michela Palmisano, Alessandra Gargano, Bolanle Fatimat Olabiyi, Beat Lutz, Andras Bilkei-Gorzo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 26 (2022)
Endocannabinoid system activity declines with age in the hippocampus, along with the density of the cannabinoid receptor type-1 (CB1). This process might contribute to brain ageing, as previous studies showed that the constitutive deletion of the CB1
Externí odkaz:
https://doaj.org/article/4e35024927f14593ba32303e693ad90c
Autor:
Prakash Nidadavolu, Andras Bilkei-Gorzo, Michael Krämer, Britta Schürmann, Michela Palmisano, Eva C. Beins, Burkhard Madea, Andreas Zimmer
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Decline in cognitive performance, an aspect of the normal aging process, is influenced by the endocannabinoid system (ECS). Cannabinoid receptor 1 (CB1) signaling diminishes with advancing age in specific brain regions that regulate learning and memo
Externí odkaz:
https://doaj.org/article/331c0a3df30e4845b83752232033d0a3
Autor:
Prakash Nidadavolu, Andras Bilkei-Gorzo, Felix Effah, Este Leidmaa, Britta Schürmann, Moritz Berger, Laura Bindila, Matthias Schmid, Beat Lutz, Andreas Zimmer, Alexis Bailey
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10254 (2022)
Endocannabinoid (eCB) signaling is markedly decreased in the hippocampus (Hip) of aged mice, and the genetic deletion of the cannabinoid receptor type 1 (CB1) leads to an early onset of cognitive decline and age-related histological changes in the br
Externí odkaz:
https://doaj.org/article/9e4347481939482e911fbd1a9b5f9400
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 5 (2020)
Our laboratory and others have previously shown that cannabinoid receptor type-1 (CB1r) activity is neuroprotective and a modulator of brain ageing; a genetic disruption of CB1r signaling accelerates brain ageing, whereas the pharmacological stimulat
Externí odkaz:
https://doaj.org/article/dec7d0489bd9410f9770d2400515fcaf
Autor:
Frank Ativie, Joanna A. Komorowska, Eva Beins, Önder Albayram, Till Zimmer, Andreas Zimmer, Dario Tejera, Michael Heneka, Andras Bilkei-Gorzo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Microglia, the resident immune cells of the brain, play important roles in defending the brain against pathogens and supporting neuronal circuit plasticity. Chronic or excessive pro-inflammatory responses of microglia damage neurons, therefore their
Externí odkaz:
https://doaj.org/article/2631b4ed0f0842a99e098554b98d8ad4
Autor:
Andras Bilkei-Gorzo, Onder Albayram, Frank Ativie, Safak Chasan, Till Zimmer, Karsten Bach, Andreas Zimmer
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202566 (2018)
Astrocytes, key regulators of brain homeostasis, interact with neighboring glial cells, neurons and the vasculature through complex processes involving different signaling pathways. It is not entirely clear how these interactions change in the ageing
Externí odkaz:
https://doaj.org/article/08a12914318e451abdd4d47423cd1df2
Autor:
Felix Schreiner, Merle Ackermann, Michael Michalik, Eva Hucklenbruch-Rother, Andras Bilkei-Gorzo, Ildiko Racz, Laura Bindila, Beat Lutz, Jörg Dötsch, Andreas Zimmer, Joachim Woelfle
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182754 (2017)
Nutrient deprivation during early development has been associated with the predisposition to metabolic disorders in adulthood. Considering its interaction with metabolism, appetite and behavior, the endocannabinoid (eCB) system represents a promising
Externí odkaz:
https://doaj.org/article/2586768670e54d2aa33d750757043dea