Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Andra, Zamurs"'
Autor:
William R. Thelin, Judith A. St. George, Ray A. Caldwell, Jim Zhang, Richard C. Boucher, Boyoung Cha, Kevin B. Johnson, Juan R. Sabater, Andra Zamurs, Mark Donowitz, Jacquelyn Fleegle, Andrew J. Hirsh, William M. Abraham, M. Ross Johnson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 325:77-88
Amiloride improves mucociliary clearance (MC) by blocking airway epithelial sodium channels (ENaC) and expanding airway surface liquid (ASL). However, the low potency and rapid absorption of amiloride by airway epithelia translated into a short durat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41961eca362e1eeea60ee2f1ab91cce9
https://doi.org/10.1124/jpet.107.130443
https://doi.org/10.1124/jpet.107.130443
Autor:
Jianzhong Zhang, Rick T. Smith, William B. Geiss, Sargent Bruce J, and Andra Zamurs, Nadezhda Astakhova, Richard C. Boucher, Alexander Usyatinsky, Michael J. Wyle, Andrew J. Hirsh, M. Ross Johnson, Brian Swenson, Bruce F. Molino
Publikováno v:
Journal of medicinal chemistry. 49(14)
Amiloride (1), the prototypical epithelial sodium channel (ENaC) blocker, has been administered with limited success as aerosol therapy for improving pulmonary function in patients with the genetic disorder cystic fibrosis. This study was conducted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b81ac670d089d477dc83c28733956c
https://pubmed.ncbi.nlm.nih.gov/16821771
https://pubmed.ncbi.nlm.nih.gov/16821771
Autor:
Anthony M. Paradiso, Sam Hopkins, Andrew J. Hirsh, Richard C. Boucher, Juan R. Sabater, Andra Zamurs, Rick T. Smith, William M. Abraham
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 311(3)
Epithelial sodium channel (ENaC) blockers have been proposed as a therapy to restore mucus clearance (MC) in cystic fibrosis (CF) airways. The therapeutic effects of the first generation ENaC blocker, amiloride, in CF patients, however, were minimal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a9f644e4eafbae86d42baeebff10c8
https://pubmed.ncbi.nlm.nih.gov/15273255
https://pubmed.ncbi.nlm.nih.gov/15273255
Autor:
J, Hirsh Andrew, R, Sabater Juan, Andra, Zamurs, T, Smith Rick, M, Paradiso Anthony, Sam, Hopkins, M, Abraham William, C, Boucher Richard
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; December 2004, Vol. 311 Issue: 3 p929-38, 10p