Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi

Autor: Natacha Cerny, Augusto Ernesto Bivona, Andrés Sanchez Alberti, Sebastián Nicolás Trinitario, Celina Morales, Alejandro Cardoso Landaburu, Silvia Inés Cazorla, Emilio Luis Malchiodi

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21 Latin American countries and the southern United States and now is spreading into several other countries due to migration. Despite the efforts to control the vector t

Externí odkaz: https://doaj.org/article/1f5f5aa373ee4b9aa10d6cb20f5a02bb

Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection

Autor: Andrés Sanchez Alberti, Augusto E. Bivona, Natacha Cerny, Kai Schulze, Sebastian Weißmann, Thomas Ebensen, Celina Morales, Angel M. Padilla, Silvia I. Cazorla, Rick L. Tarleton, Carlos A. Guzmán, Emilio L. Malchiodi

Publikováno v: npj Vaccines, Vol 2, Iss 1, Pp 1-12 (2017)

Chagas disease: protecting from chronic parasitic disease An amalgamation of parasitic proteins may be the first effective vaccine against the as yet untreatable chronic phase of Chagas disease. The infliction, caused by the parasite Trypanosoma cruz

Externí odkaz: https://doaj.org/article/ae1f0273188b48babe69f8e20ee1e766

Activity of Estafietin and Analogues on Trypanosoma cruzi and Leishmania braziliensis

Autor: Valeria P. Sülsen, Emilio F. Lizarraga, Orlando G. Elso, Natacha Cerny, Andrés Sanchez Alberti, Augusto E. Bivona, Emilio L. Malchiodi, Silvia I. Cazorla, César A. N. Catalán

Publikováno v: Molecules, Vol 24, Iss 7, p 1209 (2019)

Sesquiterpene lactones are naturally occurring compounds mainly found in the Asteraceae family. These types of plant metabolites display a wide range of biological activities, including antiprotozoal activity and are considered interesting structures

Externí odkaz: https://doaj.org/article/f60dd663bca04a0fa37f4b14630b4c0b

Chagas disease vaccine design: the search for an efficient Trypanosoma cruzi immune-mediated control

Autor: Augusto Ernesto Bivona, Sebastián Nicolás Trinitario, Natacha Cerny, Andrés Sanchez Alberti, Emilio L. Malchiodi

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Chagas disease is currently endemic to 21 Latin-American countries and has also become a global concern because of globalization and mass migration of chronically infected individuals. Prophylactic and therapeutic vaccination might contribute to cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17641e0b64c8bf806fe32c5818cf5b02
https://pubmed.ncbi.nlm.nih.gov/31904415

Trypanosoma cruzi 80 kDa prolyl oligopeptidase (Tc80) as a novel immunogen for Chagas disease vaccine

Autor: Celina Morales, Germán González, Alejandro C. Cardoso, Marina N. Matos, Emilio L. Malchiodi, Silvia I. Cazorla, Natacha Cerny, Andrés Sanchez Alberti, Augusto Ernesto Bivona

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006384 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background Chagas disease, also known as American Trypanosomiasis, is a chronic parasitic disease caused by the flagellated protozoan Trypanosoma cruzi that affects about 8 million people around the world where more than 25 million are at risk of con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e75a647a331de01ff4b8f8cdd86b673
http://europepmc.org/articles/PMC5895069