Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Andrés Norambuena"'
Autor:
Andrés Norambuena, Xuehan Sun, Horst Wallrabe, Ruofan Cao, Naidi Sun, Evelyn Pardo, Nutan Shivange, Dora Bigler Wang, Lisa A. Post, Heather A. Ferris, Song Hu, Ammasi Periasamy, George S. Bloom
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105737- (2022)
Altered mitochondrial DNA (mtDNA) occurs in neurodegenerative disorders like Alzheimer's disease (AD); how mtDNA synthesis is linked to neurodegeneration is poorly understood. We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), a
Externí odkaz:
https://doaj.org/article/0571f575ba894236ad90237fcfccbe8e
A Novel Communication Pathway Between Lysosomes and Mitochondria Is Disrupted in Alzheimer’s Disease
Autor:
Andrés Norambuena, George S. Bloom
Publikováno v:
Contact, Vol 2 (2019)
A growing body of evidence supports the idea that organelles talk to each other. This communication is characterized by either physical interactions, functional associations mediated by signaling molecules, or both. This flow of information allows th
Externí odkaz:
https://doaj.org/article/14bf33683698458f9d7f5dfcadd307c3
Autor:
Xuehan Sun, Guillermo Eastman, Yu Shi, Subhi Saibaba, Ana K. Oliveira, John R. Lukens, Andrés Norambuena, James W. Mandell, George S. Bloom
INTRODUCTIONNeuronal nuclei are normally smoothly surfaced. In Alzheimer’s disease (AD) and other tauopathies, though, they often develop invaginations. We investigated mechanisms and functional consequences of neuronal nuclear invagination in tauo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f8d70c75c33989289d853aa6e29b36
https://doi.org/10.1101/2023.05.08.539873
https://doi.org/10.1101/2023.05.08.539873
Autor:
Ruofan Cao, George S. Bloom, Dora Bigler Wang, Xuehan Sun, Horst Wallrabe, Heather A. Ferris, Ammasi Periasamy, Shivange N, Naidi Sun, Evelyn Pardo, Andrés Norambuena, Post La, Song Hu
Altered mitochondrial DNA (mtDNA) occurs in neurodegenerative disorders like Alzheimer’s disease (AD); how mtDNA synthesis is linked to neurodegeneration is poorly understood. We discovered Nutrient-induced Mitochondrial Activity (NiMA), an inter-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c6cf2e82f2270c1ae54e42d0e342c4
https://doi.org/10.1101/2021.06.14.448281
https://doi.org/10.1101/2021.06.14.448281
Autor:
Andrés Norambuena, Mehmet Murat Koseoglu, George S. Bloom, John S. Lazo, Elizabeth R. Sharlow
Publikováno v:
J Alzheimers Dis
Aberrant neuronal cell cycle re-entry (CCR) is a phenomenon that precedes and may mechanistically lead to a majority of the neuronal loss observed in Alzheimer’s disease (AD). Recent developments concerning the regulation of aberrant neuronal CCR i
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Antonia Silva, Horst Wallrabe, George S. Bloom, Erin Kodis, Shahzad S. Khan, Salvatore Oddo, Daniel Baerthlein, Eric Swanson, Lloyd McMahon, James Mandell, Andrés Norambuena
Publikováno v:
Alzheimer's & Dementia. 13:152-167
A major obstacle to pre-symptomatic diagnosis and disease-modifying therapy for Alzheimer's disease (AD) is inadequate understanding of molecular mechanisms of AD pathogenesis. For example, impaired brain insulin signaling is an AD hallmark, but whet
Autor:
George S. Bloom, Ana Lira, Michael W. Epperly, Joel S. Greenberger, Elizabeth R. Sharlow, John S. Lazo, Andrés Norambuena, Stephanie Leimgruber, Michael J. McConnell
Publikováno v:
ACS Chemical Biology. 11:1428-1437
Individuals are at risk of exposure to acute ionizing radiation (IR) from a nuclear accident or terrorism, but we lack effective therapies to mitigate the lethal IR effects. In the current study, we exploited an optimized, cell-based, high throughput
Autor:
Doo Yeon Kim, Rudolph E. Tanzi, George S. Bloom, Antonia Silva, Zdenek Svindrych, Ammasi Periasamy, Song Hu, Rui Cao, Dora Bigler Wang, Horst Wallrabe, Andrés Norambuena
The mechanisms of mitochondrial dysfunction in Alzheimer's disease are incompletely understood. Using two-photon fluorescence lifetime microscopy of the coenzymes, NADH and NADPH, and tracking brain oxygen metabolism with multi-parametric photoacoust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a7a590824c0495293a31aca945f3e6
https://europepmc.org/articles/PMC6236329/
https://europepmc.org/articles/PMC6236329/
Autor:
George S. Bloom, Andrés Norambuena
Publikováno v:
Oilseeds and fats, crops and lipids, Vol 25, Iss 4, p D403 (2018)
Alzheimer’s disease (AD) is defined by memory loss and cognitive impairment, along with the accumulation in brain of two types of abnormal structures, extracellular amyloid plaques and intraneuronal neurofibrillary tangles. Both plaques and tangles