Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrés Guillén-Samander"'
Autor:
Nica Borgese, Andrés Guillén-Samander, Sara Francesca Colombo, Giulia Mancassola, Federica Di Berardino, Diego Zanetti, Paola Carrera
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2657 (2023)
Sensorineural age-related hearing loss affects a large proportion of the elderly population, and has both environmental and genetic causes. Notwithstanding increasing interest in this debilitating condition, the genetic risk factors remain largely un
Externí odkaz:
https://doaj.org/article/206639dbb97c4208bef9c25b323f0551
Publikováno v:
Cold Spring Harbor perspectives in biology.
The Endoplasmic Reticulum (ER) is an endomembrane system that plays a multiplicity of roles in cell physiology and populates even the most distal cell compartments, including dendritic tips and axon terminals of neurons. Some of its functions are ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c4a5ff9c703bf61b540960aa2c9103
https://pubmed.ncbi.nlm.nih.gov/36123033
https://pubmed.ncbi.nlm.nih.gov/36123033
Autor:
Andrés Guillén-Samander, Yumei Wu, S. Sebastian Pineda, Francisco J. García, Julia N. Eisen, Marianna Leonzino, Berrak Ugur, Manolis Kellis, Myriam Heiman, Pietro De Camilli
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Chorea-acanthocytosis (ChAc) and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectively. Key features of these conditions are the degeneration of caudate neurons and the presence of abnorma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6721284e1c8bc2066f28e31ea6095e0
https://doi.org/10.1073/pnas.2205425119
https://doi.org/10.1073/pnas.2205425119
Autor:
Shujun Cai, Yumei Wu, Andrés Guillén-Samander, William Hancock-Cerutti, Jun Liu, Pietro De Camilli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(29)
VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like mechanism. Direct evidence for this hypothesis from a full-length str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255ef4d3eff907a598cc2301f459432b
https://pubmed.ncbi.nlm.nih.gov/35858323
https://pubmed.ncbi.nlm.nih.gov/35858323
Autor:
Andrés Guillén Samander, Yumei Wu, S. Sebastian Pineda, Francisco J. García, Julia N. Eisen, Marianna Leonzino, Berrak Uğur, Manolis Kellis, Myriam Heiman, Pietro De Camilli
Chorea-acanthocytosis and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectively. Key features of these conditions are the degeneration of caudate neurons and the presence of abnormally sha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecec7dc7ac2a28745f37570193026718
https://doi.org/10.1101/2022.03.30.486314
https://doi.org/10.1101/2022.03.30.486314
Autor:
Yiying Cai, Pietro De Camilli, Andrés Guillén-Samander, Yumei Wu, Mirko Messa, Elizabeth Wen Sun, Xin Bian
Publikováno v:
Proceedings of the National Academy of Sciences. 116:5775-5784
Close appositions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are a general feature of all cells and are abundant in neurons. A function of these appositions is lipid transport between the two adjacent bilayers via tethering p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ffd79cbee682294a6ea721cfe5ad51
https://doi.org/10.1073/pnas.1820156116
https://doi.org/10.1073/pnas.1820156116
Autor:
Andrés Guillén-Samander
This protocol describes the basic molecular cloning technique utilized for the generation of VPS13D constructs in https://doi.org/10.1083/jcb.202010004. This protocol and the enzymes included in it are commercialized by Takara Bio. Due to low express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83b5a0a012caa6544b8fdde908d77915
https://doi.org/10.17504/protocols.io.bvgwn3xe
https://doi.org/10.17504/protocols.io.bvgwn3xe
Autor:
Andrés Guillén-Samander
This protocol details the procedure for preparation of neuronal cultures from mice hippocampi as it was performed in https://doi.org/10.1083/jcb.202010004 but can also be used to prepare cultures of cortical neurons.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7b8b5e2bebfd2f42aa63f24c21b8ee8
https://doi.org/10.17504/protocols.io.bvgkn3uw
https://doi.org/10.17504/protocols.io.bvgkn3uw
Autor:
Ni Tang, Marianna Leonzino, Michael G. Hanna, Pietro De Camilli, Hongying Shen, Andrés Guillén-Samander
Publikováno v:
The Journal of Cell Biology
Mitochondria, which are excluded from the secretory pathway, depend on lipid transport proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the outer mitochondrial membrane GTPase Gem1 is an accessory factor of ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7c0b01ef6f1d9228f7ea779faab661
http://europepmc.org/articles/PMC8340359
http://europepmc.org/articles/PMC8340359
Autor:
Pietro De Camilli, Michael G. Hanna, Hongying Shen, Andrés Guillén-Samander, Ni Tang, Marianna Leonzino
Publikováno v:
The Journal of Cell Biology
VPS13D mutations result in severe mitochondrial defects. Guillén-Samander et al. show that VPS13D binds VAP in the ER and interacts with Miro on mitochondria and peroxisomes, where it could provide a bridge for lipid transport between these organell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50df131b110aad2b3f7c7118bfe03fd0
http://europepmc.org/articles/PMC8077184
http://europepmc.org/articles/PMC8077184