Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Andrés A. Trabanco"'
Autor:
Ana I. de Lucas, Juan A. Vega, Aránzazu García Molina, María Lourdes Linares, Gary Tresadern, Hilde Lavreysen, Daniel Oehlrich, Andrés A. Trabanco, José M. Cid
Publikováno v:
ACS Omega, Vol 6, Iss 35, Pp 22997-23006 (2021)
Externí odkaz:
https://doaj.org/article/f163c53639314ff082650d81360b53d9
Autor:
Luke A. Miles, Stefan J. Hermans, Gabriela A.N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andrés A. Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C. Hancock, Michael W. Parker
Publikováno v:
iScience, Vol 19, Iss , Pp 110-118 (2019)
Summary: Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might be an effective therapy aga
Externí odkaz:
https://doaj.org/article/22f8a82eaea94df5bb89f782ed04cc2d
Autor:
Frederik J. R. Rombouts, Richard Alexander, Erna Cleiren, Alex De Groot, Michel Carpentier, Joyce Dijkmans, Katleen Fierens, Stefan Masure, Diederik Moechars, Martina Palomino-Schätzlein, Antonio Pineda-Lucena, Andrés A. Trabanco, Daan Van Glabbeek, Ann Vos, Gary Tresadern
Publikováno v:
ACS Omega, Vol 2, Iss 2, Pp 685-697 (2017)
Externí odkaz:
https://doaj.org/article/b8afeb20f88a4af39591a00477541482
Autor:
Ann Vos, Frederik Jan Rita Rombouts, Andrés A. Trabanco, Daniel Oehlrich, Harrie J.M. Gijsen, Diederik Moechars, Sven Franciscus Anna Van Brandt, Aldo Peschiulli, Gregor James Macdonald, Michel Surkyn, Gary Tresadern, Michiel Van Gool, Nigel E. Austin, Michel Anna Jozef De Cleyn
Publikováno v:
ACS Med Chem Lett
[Image: see text] We recently disclosed a set of heteroaryl-fused piperazine inhibitors of BACE1 that combined nanomolar potency with good intrinsic permeability and low Pgp-mediated efflux. Herein we describe further work on two prototypes of this f
Autor:
Hilde Lavreysen, Ana Isabel de Lucas, Juan Antonio Vega, Gary Tresadern, Daniel Oehlrich, Aránzazu García Molina, Andrés A. Trabanco, María Lourdes Linares, José María Cid
Publikováno v:
ACS Omega, Vol 6, Iss 35, Pp 22997-23006 (2021)
Glutamate hyperfunction is implicated in multiple neurological and psychiatric diseases. Activation of the mGlu2 receptor results in reduced glutamate release and decreased excitability representing a promising novel therapeutic agent for the treatme
Autor:
José Manuel Bartolomé-Nebreda, Adriana Ingrid Velter, Peter Jacobus Johannes Antonius Buijnsters, Andrés A. Trabanco
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:1117-1154
Introduction: O-GlcNAcylation is a highly abundant post-translational modification of multiple proteins, including the microtubule-binding protein tau, governed by just two enzymes’ concerted actio...
Autor:
Andrés A. Trabanco, Jeroen B. I. Sap, Christopher W. am Ende, Claudio F. Meyer, Ndidi Iwumene, Natan J. W. Straathof, Véronique Gouverneur
Publikováno v:
Chemical Society Reviews. 50:8214-8247
This review describes the recent advances made in difluoromethylation processes based on X–CF2H bond formation where X is C(sp), C(sp2), C(sp3), O, N or S, a field of research that has benefited from the invention of multiple difluoromethylation re
Autor:
Francisca Delgado, Jordi Royes, Alcira del Cerro, Fulgencio Tovar, Juan Antonio Vega, Paul Shaffer, Andrés A. Trabanco, Elena Fernández, Alexis Bretteville, Gary Tresadern, Andreas Ebneth, José Manuel Bartolomé-Nebreda, Carlos M Martínez-Viturro, Liesbeth Mertens, Marijke Somers, Aránzazu García Molina, José Manuel Alonso
Publikováno v:
Journal of Medicinal Chemistry. 63:14017-14044
O-GlcNAcylation is a post-translational modification of tau understood to lower the speed and yield of its aggregation, a pathological hallmark of Alzheimer's disease (AD). O-GlcNAcase (OGA) is the only enzyme that removes O-linked N-acetyl-d-glucosa
Autor:
Frans A. F. Van den Keybus, Peter Jacobus Johannes Antonius Buijnsters, Andrés A. Trabanco, Marijke Somers, Marieke Lamers, Gary Tresadern, Greet Vanhoof, Yves Emiel Maria Van Roosbroeck, Gregor James Macdonald, Ingrid Velter, Philip Leonard
Publikováno v:
Journal of Medicinal Chemistry. 63:12887-12910
We describe the hit-to-lead exploration of a [1,2,4]triazolo[1,5-a]pyrimidine phosphodiesterase 2A (PDE2A) inhibitor arising from high-throughput screening. X-ray crystallography enabled structure-guided design, leading to the identification of prefe
Autor:
Kirsten K. Christensen, Sandrine M. Hell, Michael C. Willis, Jeroen B. I. Sap, Claudio F. Meyer, Véronique Gouverneur, Andrés A. Trabanco, Antonio Misale
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Sulfonyl chlorides are inexpensive reactants extensively explored for functionalization, but never considered for radical hydrosulfonylation of alkenes. Herein, we report that tris(trimethylsilyl)silane is an ideal hydrogen atom donor enabling highly