Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrés, Ingason"'
Autor:
Joeri Meijsen, Kejia Hu, Morten D. Krebs, Georgios Athanasiadis, Sarah Washbrook, Richard Zetterberg, Raquel Nogueira Avelar e Silva, John R. Shorter, Jesper R. Gådin, Jacob Bergstedt, David M. Howard, Weimin Ye, Yi Lu, Unnur A. Valdimarsdóttir, Andrés Ingason, Dorte Helenius, Oleguer Plana-Ripoll, John J. McGrath, Nadia Micali, Ole A. Andreassen, Thomas M. Werge, Fang Fang, Alfonso Buil
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records
Externí odkaz:
https://doaj.org/article/b590855b0172469c974a0c55e5a42e1d
Autor:
Julie Courraud, Francesco Russo, Gonçalo Espregueira Themudo, Susan Svane Laursen, Andrés Ingason, David M. Hougaard, Arieh S. Cohen, Thomas Werge, Madeleine Ernst
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Large deletions at chromosome 22q11.2 are known to cause severe clinical conditions collectively known as 22q11.2 deletion syndrome. Notwithstanding the pathogenicity of these deletions, affected individuals are typically diagnosed in late c
Externí odkaz:
https://doaj.org/article/a050d5ab6328456b99c5b16d3916ae51
Autor:
Clara Albiñana, Zhihong Zhu, Andrew J. Schork, Andrés Ingason, Hugues Aschard, Isabell Brikell, Cynthia M. Bulik, Liselotte V. Petersen, Esben Agerbo, Jakob Grove, Merete Nordentoft, David M. Hougaard, Thomas Werge, Anders D. Børglum, Preben Bo Mortensen, John J. McGrath, Benjamin M. Neale, Florian Privé, Bjarni J. Vilhjálmsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effec
Externí odkaz:
https://doaj.org/article/65c6fd7da745423fbb7f56199da61c83
Autor:
Karina Banasik, Peter L. Møller, Tanya R. Techlo, Peter C. Holm, G. Bragi Walters, Andrés Ingason, Anders Rosengren, Palle D. Rohde, Lisette J. A. Kogelman, David Westergaard, Troels Siggaard, Piotr J. Chmura, Mona A. Chalmer, Ólafur Þ. Magnússon, Guðmundur Á. Þórisson, Hreinn Stefánsson, Daníel F. Guðbjartsson, Kári Stefánsson, Jes Olesen, Simon Winther, Morten Bøttcher, Søren Brunak, Thomas Werge, Mette Nyegaard, Thomas F. Hansen
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-4 (2023)
Abstract Objectives Allele counts of sequence variants obtained by whole genome sequencing (WGS) often play a central role in interpreting the results of genetic and genomic research. However, such variant counts are not readily available for individ
Externí odkaz:
https://doaj.org/article/e113e373bf77483e9c84853837f696bb
Autor:
Anders Fischer, Karl-Göran Sjögren, Theis Zetner Trolle Jensen, Marie Louise Jørkov, Per Lysdahl, Tharsika Vimala, Alba Refoyo-Martínez, Gabriele Scorrano, T. Douglas Price, Darren R. Gröcke, Anne Birgitte Gotfredsen, Lasse Sørensen, Verner Alexandersen, Sidsel Wåhlin, Jesper Stenderup, Ole Bennike, Andrés Ingason, Rune Iversen, Martin Sikora, Fernando Racimo, Eske Willerslev, Morten E. Allentoft, Kristian Kristiansen
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/742a848e8c81432b8494f1ecd35e97ca
Autor:
Vivek Appadurai, Jonas Bybjerg-Grauholm, Morten Dybdahl Krebs, Anders Rosengren, Alfonso Buil, Andrés Ingason, Ole Mors, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Preben B. Mortensen, Olivier Delaneau, Thomas Werge, Andrew J. Schork
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
An analysis of phasing and imputation performances using iPSYCH consortium data across multiple methods and data integration protocols provides a useful framework in designing workflows to construct next-generation biobanks or conduct biobank-scale a
Externí odkaz:
https://doaj.org/article/da68746f7ed94072a9a90b5153feccaf
Autor:
Lasse Folkersen, Oliver Pain, Andrés Ingason, Thomas Werge, Cathryn M. Lewis, Jehannine Austin
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
To date, interpretation of genomic information has focused on single variants conferring disease risk, but most disorders of major public concern have a polygenic architecture. Polygenic risk scores (PRSs) give a single measure of disease liability b
Externí odkaz:
https://doaj.org/article/97a57f4460604774bfc4c2617af37a37
Autor:
John R. Shorter, Joeri Meijsen, Ron Nudel, Morten Krebs, Jesper Gådin, Dorte H. Mikkelsen, Raquel Nogueira Avelar e Silva, Michael E. Benros, Wesley K. Thompson, Andrés Ingason, Thomas Werge
Publikováno v:
Shorter, J R, Meijsen, J, Nudel, R, Krebs, M, Gådin, J, Mikkelsen, D H, Nogueira Avelar e Silva, R, Benros, M E, Thompson, W K, Ingason, A & Werge, T 2022, ' Infection Polygenic Factors Account for a Small Proportion of the Relationship Between Infections and Mental Disorders ', Biological Psychiatry, vol. 92, no. 4, pp. 283-290 . https://doi.org/10.1016/j.biopsych.2022.01.007
Background: Several recent studies have suggested a role for infections in the development of mental disorders; however, the genetic contribution to this association is understudied. Methods: We use the iPSYCH case-cohort genotyped sample (n = 65,534
Autor:
Niamh Mullins, Andrés Ingason, Heather Porter, Jack Euesden, Alexandra Gillett, Sigurgeir Ólafsson, Daniel F. Gudbjartsson, Cathryn M. Lewis, Engilbert Sigurdsson, Evald Saemundsen, Ólafur Ó Gudmundsson, Michael L. Frigge, Augustine Kong, Agnar Helgason, G. Bragi Walters, Omar Gustafsson, Hreinn Stefansson, Kari Stefansson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Why genetic variants that confer risk for psychiatric disorders persist in the genome is an evolutionary conundrum. Here, Mullinset al. report association of polygenic risk for autism with having fewer children and polygenic risk for ADHD with higher
Externí odkaz:
https://doaj.org/article/6a60e54dd24e47ccb00660d46b48e9ad
Autor:
Evan K. Irving-Pease, Alba Refoyo-Martínez, Andrés Ingason, Alice Pearson, Anders Fischer, William Barrie, Karl-Göran Sjögren, Alma S. Halgren, Ruairidh Macleod, Fabrice Demeter, Rasmus A. Henriksen, Tharsika Vimala, Hugh McColl, Andrew Vaughn, Aaron J. Stern, Leo Speidel, Gabriele Scorrano, Abigail Ramsøe, Andrew J. Schork, Anders Rosengren, Lei Zhao, Kristian Kristiansen, Peter H. Sudmant, Daniel J. Lawson, Richard Durbin, Thorfinn Korneliussen, Thomas Werge, Morten E. Allentoft, Martin Sikora, Rasmus Nielsen, Fernando Racimo, Eske Willerslev
Publikováno v:
bioRxiv
Summary The Eurasian Holocene (beginning c. 12 thousand years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f594d2e8bb4f3741126ae18f5d80cb
https://doi.org/10.1101/2022.09.22.509027
https://doi.org/10.1101/2022.09.22.509027