Innovative Approaches to Assess Intermediate Cardiovascular Risk Subjects: A Review From Clinical to Metabolomics Strategies

Autor: Aline M. A. Martins, Mariana U. B. Paiva, Diego V. N. Paiva, Raphaela M. de Oliveira, Henrique L. Machado, Leonardo J. S. R. Alves, Carolina R. C. Picossi, Andréa T. Faccio, Marina F. M. Tavares, Coral Barbas, Viviane Z. R. Giraldez, Raul D. Santos, Guilherme U. Monte, Fernando A. Atik

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Current risk stratification strategies for coronary artery disease (CAD) have low predictive value in asymptomatic subjects classified as intermediate cardiovascular risk. This is relevant because not all coronary events occur in individuals with tra

Externí odkaz: https://doaj.org/article/d6584e3a3fdd4d97bf98652b39b57a6a

Analytical Platforms for Mass Spectrometry-Based Metabolomics of Polar and Ionizable Metabolites

Autor: Marina Franco Maggi Tavares, Tatiana S. Fukuji, Andréa T Faccio, Adriana Nori de Macedo, Gisele André Baptista Canuto

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9783030772512

Metabolomics studies rely on the availability of suitable analytical platforms to determine a vast collection of chemically diverse metabolites in complex biospecimens. Liquid chromatography-mass spectrometry operated under reversed-phase conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbc4dd2d8ddde10775e9fc2e1677e192
https://doi.org/10.1007/978-3-030-77252-9_11

Stereochemical and structural effects of (2R,6R)-hydroxynorketamine on the mitochondrial metabolome in PC-12 cells

Autor: Michel Bernier, Andréa T. Faccio, Nagendra Singh, Marina Franco Maggi Tavares, Francisco J. Rupérez, Coral Barbas, Irving W. Wainer, Santiago Angulo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background Impairment in mitochondrial biogenesis and function plays a key role in depression and anxiety, both of which being associated with changes in fatty acid and phospholipid metabolism. The antidepressant effects of (R,S)-ketamine have been l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5966f1539230194612ca16144ccbce2
https://doi.org/10.1016/j.bbagen.2018.03.008

METABOLOMICS: DEFINITIONS, STATE-OF-THE-ART AND REPRESENTATIVE APPLICATIONS

Autor: Gisele André Baptista Canuto, Ana Rosa Lins de Souza, Andréa T Faccio, Marina Franco Maggi Tavares, Aline Klassen, Karina T. Rodrigues, Jose Luiz Costa, Pedro Luis Rocha da Cruz

Publikováno v: Química Nova, Volume: 41, Issue: 1, Pages: 75-91, Published: JAN 2018
Química Nova v.41 n.1 2018
Química Nova
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Química Nova, Vol 41, Iss 1, Pp 75-91

Metabolomics is an emerging and promising omics approach used to understand biological mechanisms. By untargeted and targeted metabolomics analyses, metabolites are determined in biological samples (fluids, cells, tissues, etc.) by comparison of cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802b03da4ed63d843e744ced0f60d52c
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018000100075&lng=en&tlng=en

Metabolomics: Definitions and Significance in Systems Biology

Autor: Alessandra Sussulini, Gisele André Baptista Canuto, Henrique Caracho Ribeiro, Marina Franco Maggi Tavares, Pedro Luis Rocha da Cruz, Andréa T Faccio, Aline Klassen

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9783319476551

Nowadays, there is a growing interest in deeply understanding biological mechanisms not only at the molecular level (biological components) but also the effects of an ongoing biological process in the organism as a whole (biological functionality), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7851517144eb64e323794600525cda8b
https://doi.org/10.1007/978-3-319-47656-8_1