Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andréa E. Tijhuis"'
Autor:
Lorenza Garribba, Giuseppina De Feudis, Valentino Martis, Martina Galli, Marie Dumont, Yonatan Eliezer, René Wardenaar, Marica Rosaria Ippolito, Divya Ramalingam Iyer, Andréa E. Tijhuis, Diana C. J. Spierings, Michael Schubert, Silvia Taglietti, Chiara Soriani, Simon Gemble, Renata Basto, Nick Rhind, Floris Foijer, Uri Ben-David, Daniele Fachinetti, Ylli Doksani, Stefano Santaguida
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
Externí odkaz:
https://doaj.org/article/e226f0a659b0484e8d7815070b875a08
Publikováno v:
Molecular Cytogenetics, Vol 12, Iss 1, Pp 1-21 (2019)
Abstract Many cancers possess an incorrect number of chromosomes, a state described as aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of continuous chromosome mis-segregation. CIN is believed to endow tumours with
Externí odkaz:
https://doaj.org/article/51e07b647894455c91fc83d94fe3dc60
Autor:
Christy Hong, Michael Schubert, Andréa E. Tijhuis, Marta Requesens, Maurits Roorda, Anouk van den Brink, Lorena Andrade Ruiz, Petra L. Bakker, Tineke van der Sluis, Wietske Pieters, Mengting Chen, René Wardenaar, Bert van der Vegt, Diana C. J. Spierings, Marco de Bruyn, Marcel A. T. M. van Vugt, Floris Foijer
Publikováno v:
Nature, 607, 366-373. Nature Publishing Group
Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy resistance, and is associated with poor prognosis1. CIN leads to micronuclei that release DNA into the cytoplasm after rupture, which triggers activation of inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69063ca0b506444ff7a219944f9795e2
https://research.rug.nl/en/publications/ff2b416b-ddea-483f-994c-679b01e479a0
https://research.rug.nl/en/publications/ff2b416b-ddea-483f-994c-679b01e479a0
Autor:
Andrea Scelfo, Viviana Barra, Nezar Abdennur, George Spracklin, Florence Busato, Catalina Salinas-Luypaert, Elena Bonaiti, Guillaume Velasco, Anna Chipont, Coralie Guérin, Andréa E. Tijhuis, Diana C.J. Spierings, Claire Francastel, Floris Foijer, Jorg Tost, Leonid Mirny, D. Fachinetti
DNA methylation (DNAme) is a key epigenetic mark that regulates critical biological processes maintaining overall genome stability. Given its pleiotropic function, studies of DNAme dynamics are crucial, but currently available tools to interfere with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::425ae1c819f03d26eb813a7ecb5437d1
https://doi.org/10.1101/2023.05.04.539406
https://doi.org/10.1101/2023.05.04.539406
Autor:
Sara Martin, René Wardenaar, Marica Rosaria Ippolito, Daniele Fachinetti, Valentino Martis, Floris Foijer, Uri Ben-David, Stefano Santaguida, Andréa E. Tijhuis, Christy Hong, Diana C.J. Spierings, Marie Dumont, Johanna Zerbib
Publikováno v:
Developmental Cell, 56(17), 2440-2454. CELL PRESS
Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21091e4b152b91cf74389b44f601efda
https://doi.org/10.1016/j.devcel.2021.07.006
https://doi.org/10.1016/j.devcel.2021.07.006
Autor:
Michael Schubert, Christy Hong, Laura J. Jilderda, Marta Requesens Rueda, Andréa E. Tijhuis, Judith E. Simon, Petra L. Bakker, Jon L. Cooper, Aristi Damaskou, René Wardenaar, Bjorn Bakker, Sahil Gupta, Anouk van den Brink, Lorena Andrade Ruiz, Miriam H. Koster, Sameh A. Youssef, Danielle Luinenburg, Alex Strong, Thomas Engleitner, Hannes Ponstingl, Gerald de Haan, Alain de Bruin, Roland Rad, Hans W. Nijman, René H. Medema, Marcel A.T.M. van Vugt, Marco de Bruyn, Diana C.J. Spierings, Maria Colomé-Tatché, George S. Vassiliou, Floris Foijer
Chromosomal instability is a hallmark of cancer, but also an instigator of aneuploidy-induced stress, reducing cellular fitness. To better understand how cells with CIN adjust to aneuploidy and adopt a malignant fate in vivo, we performed a genome-wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527f121bf935bcd0b7fa19d39b8526ff
https://doi.org/10.1101/2021.12.03.471107
https://doi.org/10.1101/2021.12.03.471107
Autor:
Benjamin Vitre, Diana C.J. Spierings, Dong Hyun Kim, Bjorn Bakker, Lauren de Haan, Kathleen M. Fisch, René Wardenaar, Floris Foijer, Jon Artates, Andréa E. Tijhuis, Marcus Maldonado, Yin Wang, Ouyang Zhengyu, Don W. Cleveland, Matthew A. Demarest, Ofer Shoshani, Adam Mark, Roman Sasik
Publikováno v:
Genes Dev
Genes & Development, 35(15-16), 1093-1108. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Genes & Development, 35(15-16), 1093-1108. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Abnormal numerical and structural chromosome content is frequently found in human cancer. To test the role of aneuploidy in tumor initiation and progression, we generated mice with random aneuploidies by transient induction of polo-like kinase 4 (Plk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d26351348f42921270548637cb2e52a
https://hal.archives-ouvertes.fr/hal-03367172/document
https://hal.archives-ouvertes.fr/hal-03367172/document
Autor:
Christy, Hong, Michael, Schubert, Andréa E, Tijhuis, Marta, Requesens, Maurits, Roorda, Anouk, van den Brink, Lorena Andrade, Ruiz, Petra L, Bakker, Tineke, van der Sluis, Wietske, Pieters, Mengting, Chen, René, Wardenaar, Bert, van der Vegt, Diana C J, Spierings, Marco, de Bruyn, Marcel A T M, van Vugt, Floris, Foijer
Publikováno v:
Nature. 607(7918)
Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy resistance, and is associated with poor prognosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d13a3362539de687ba6c6174a910b29
https://pubmed.ncbi.nlm.nih.gov/35915014
https://pubmed.ncbi.nlm.nih.gov/35915014
Autor:
Simon Gemble, René Wardenaar, Kristina Keuper, Nishit Srivastava, Maddalena Nano, Anne-Sophie Macé, Andréa E. Tijhuis, Sara Vanessa Bernhard, Diana C.J. Spierings, Anthony Simon, Oumou Goundiam, Helfrid Hochegger, Matthieu Piel, Floris Foijer, Zuzana Storchová, Renata Basto
Doubling of the full chromosome content -whole genome duplications (WGDs)- is frequently found in human cancers and is responsible for the rapid evolution of genetically unstable karyotypes 1–3. It has previously been established that WGDs fuel chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f90ba2da6a7b518a6098617fd789b4b
https://doi.org/10.1101/2021.07.16.452672
https://doi.org/10.1101/2021.07.16.452672
Autor:
Simon Gemble, René Wardenaar, Kristina Keuper, Nishit Srivastava, Maddalena Nano, Anne-Sophie Macé, Andréa E. Tijhuis, Sara Vanessa Bernhard, Diana C. J. Spierings, Anthony Simon, Oumou Goundiam, Helfrid Hochegger, Matthieu Piel, Floris Foijer, Zuzana Storchová, Renata Basto
Publikováno v:
Nature. 608:E27-E27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b390e6282bd997583a1531781af67604
https://doi.org/10.1038/s41586-022-05099-w
https://doi.org/10.1038/s41586-022-05099-w